P-type ATPases

A highly conserved family of ATPases that facilitate the transport of lipids and cations across the plasma membrane. Structurally, they are elongated ALPHA-HELICES constituting five functionally distinct domains: three cytoplasmic domains A, N, and P which contain the catalytic sites, and two transmembrane domains. The N domain phosphorylates the P-domain at an invariant ASPARTATE residue, which, in turn, is dephosphorylated by the A domain. The phosphorylation and dephosphorylation cycles drive conformational changes in the protein between two states (E1 and E2), which allow the substrate to access the other side of the membrane.

Also Known As:

E1-E2 ATPases; P-type Adenosine Triphosphatases; Phosphorylation-type ATPases; Phosphorylation-type Adenosine Triphosphatases; ATPase, E1-E2; ATPase, P-type; ATPases, E1-E2; ATPases, P-type; ATPases, Phosphorylation-type; Adenosine Triphosphatase, P-type; Adenosine Triphosphatases, P-type; Adenosine Triphosphatases, Phosphorylation-type; Atpase, P Type; E1 E2 ATPase; E1 E2 ATPases; P type ATPases; P type Adenosine Triphosphatase; P type Adenosine Triphosphatases; Phosphorylation type ATPases; Phosphorylation type Adenosine Triphosphatases; Triphosphatase, P-type Adenosine; Triphosphatases, P-type Adenosine; Triphosphatases, Phosphorylation-type Adenosine; Type Atpase, P; E1-E2 ATPase; P Type Atpase; P-type ATPase; P-type Adenosine Triphosphatase

Networked: 226 relevant articles (0 outcomes, 12 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Petris, Michael J: 9 articles (12/2019 - 11/2002)
2.	Takebayashi, Yuji: 9 articles (06/2005 - 01/2002)
3.	Kanzaki, Atsuko: 8 articles (04/2005 - 01/2002)
4.	Mercer, Julian F B: 7 articles (03/2010 - 11/2002)
5.	Kaler, Stephen G: 6 articles (05/2015 - 02/2003)
6.	Nakayama, Kentaro: 6 articles (01/2013 - 01/2002)
7.	Camakaris, James: 6 articles (01/2007 - 10/2002)
8.	Sugiyama, Toshihiro: 6 articles (04/2005 - 01/2002)
9.	Terada, Kunihiko: 6 articles (04/2005 - 01/2002)
10.	Ogawa, Kenji: 6 articles (03/2004 - 01/2002)

Related Diseases

1.	Hepatolenticular Degeneration (Wilson's Disease) 10/14/2007 - "To study mutations in the P-type ATPase (ATP7B) gene responsible for Wilson disease (WD) in the Eastern Chinese population, and the possible correlation of specific mutations with clinical characteristics. " 06/01/2003 - "The Wilson disease gene ATP7B encodes a P-type ATPase. " 09/01/2002 - "The accumulation of Cu is explained by the defective expression of the Cu-transporting P-type ATPase gene, homologous to the gene for Wilson's disease (ATP7B). " 01/01/1995 - "The recent cloning and sequencing of the gene for Wilson disease indicates that Cu transport in liver cells may be mediated by a Cu transporting P-type ATPase. " 09/27/1994 - "P-type ATPase from the cyanobacterium Synechococcus 7942 related to the human Menkes and Wilson disease gene products."
2.	Carcinoma (Carcinomatosis) 01/10/2003 - "This study describes the first report that a copper-transporting P-type adenosine triphosphatase, ATP7B, is expressed in human gastric carcinomas. " 06/01/2005 - "Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) as a chemoresistance marker in human solid carcinomas." 03/01/2003 - "Mutation analysis of copper-transporting P-type adenosine triphosphatase (ATP7B) in human solid carcinomas." 03/01/2003 - "Expression of copper-transporting P-type adenosine triphosphatase in human esophageal carcinoma." 01/10/2003 - "Copper-transporting P-type adenosine triphosphatase (ATP7B) is expressed in human gastric carcinoma."
3.	Menkes Kinky Hair Syndrome (Menkes Disease) 07/01/1997 - "Menkes disease has been shown to be due to mutations of the gene ATP7A which encodes P-type ATPase (referred to here as MNK). " 05/01/2015 - "ATP7A is a P-type ATPase in which diverse mutations lead to X-linked recessive Menkes disease or occipital horn syndrome. " 02/06/1998 - "Menkes disease is a fatal neurodegenerative disorder of childhood caused by the absence or dysfunction of a putative P-type ATPase encoded on the X chromosome. " 03/01/1995 - "Analysis of the CCC2p amino acid sequence reveals that it encodes a member of the P-type ATPase family and is most similar to a subfamily thought to consist of Cu2+ transporters, including the human genes that mutate to cause Wilson disease and Menkes disease. " 11/01/2013 - "In this study, a system based integrative approach was used to investigate the genome-wide effects of the deletion of the yeast ortholog of Wilson and Menkes diseases encoding a Cu(2+)-transporting P-type ATPase (CCC2) in different copper containing media and to compare with the wild type. "
4.	Infections 10/03/2012 - "Finally, the results obtained in this work provide a starting point for experimental studies that may elucidate the ion specificity of the MTBC P-type ATPases and their role in mycobacterial infections." 04/01/2018 - "Some Mycobacterium tuberculosis P-type ATPases are induced during infection, suggesting that this type of transporter could play a critical role in mycobacterial survival. " 03/23/2006 - "Here we report the characterization of a P-type ATPase-encoding gene, MgAPT2, in the economically important rice blast pathogen Magnaporthe grisea, which is required for exocytosis during plant infection. " 09/01/2001 - "PDE1 encodes a P-type ATPase involved in appressorium-mediated plant infection by the rice blast fungus Magnaporthe grisea." 11/01/2019 - "Among the 12 P-type ATPases encoded by the genome of Mycobacterium tuberculosis (Mtb), CtpF responds to the greatest number of stress conditions, including oxidative stress, hypoxia, and infection. "
5.	Neoplasms (Cancer) 08/30/2023 - "Type IV P-Type ATPases: Recent Updates in Cancer Development, Progression, and Treatment." 12/08/2018 - "Here we describe a novel TAp73 target, ATP7A a member of a large family of P-type ATPases implicated in human neurogenerative conditions and cancer chemoresistance. " 01/01/2022 - "These molecular pumps belong to P-type ATPases and dispose off the Platinum (Pt) based anticancer drugs from cancer cells, causing resistance in them. " 10/24/2017 - "Uptake of glucose-conjugated MGMT inhibitors in cancer cells: role of flippases and type IV P-type ATPases." 08/01/2014 - "Sarco-endoplasmic reticulum Ca2+-ATPase (SERCA), a P-type ATPase that sustains Ca2+ transport and plays a major role in intracellular Ca2+ homeostasis, represents a therapeutic target for cancer therapy. "

Related Drugs and Biologics

1.	Copper
2.	Platinum
3.	Cisplatin (Platino)
4.	Complementary DNA (cDNA)
5.	Copper Transporter 1
6.	Paraffin
7.	Glutathione Transferase (Glutathione S-Transferase)
8.	taxane
9.	Proteins (Proteins, Gene)
10.	Adenosine Triphosphatases (ATPase)

Related Therapies and Procedures

1.	Combination Drug Therapy (Combination Chemotherapy)
2.	Drug Therapy (Chemotherapy)
3.	Therapeutics
4.	Neoadjuvant Therapy
5.	Liver Transplantation