Polychlorinated Dibenzodioxins (TCDD)

Dibenzodioxin derivatives that contain multiple chloride atoms bound to the benzene ring structures.

Also Known As:

TCDD; 2,3,7,8-Tetrachlorodibenzo-p-dioxin; Chlorinated Dibenzo-p-dioxins; Dibenzo(b,e)(1,4)dioxin, 2,3,7,8-tetrachloro-; PCDD; Polychlorinated Dibenzo-p-dioxins; Polychlorinated Dibenzodioxin; Polychlorodibenzo-4-dioxin; Polychlorodibenzo-p-dioxin; Tetrachlorodibenzo-p-dioxin; Chlorinated Dibenzo p dioxins; Dibenzo-p-dioxins, Chlorinated; Dibenzo-p-dioxins, Polychlorinated; Dibenzodioxin, Polychlorinated; Dibenzodioxins, Polychlorinated; Polychlorinated Dibenzo p dioxins; Polychlorodibenzo 4 dioxin; Polychlorodibenzo p dioxin; Tetrachlorodibenzo p dioxin; Tetrachlorodibenzodioxin

Networked: 2278 relevant articles (43 outcomes, 378 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tohyama, Chiharu: 33 articles (01/2019 - 01/2002)
2.	Peterson, Richard E: 30 articles (01/2020 - 08/2002)
3.	Matsumura, Fumio: 24 articles (05/2015 - 03/2002)
4.	Heideman, Warren: 20 articles (07/2015 - 11/2003)
5.	Mocarelli, Paolo: 19 articles (01/2021 - 07/2002)
6.	Pohjanvirta, Raimo: 19 articles (01/2020 - 04/2004)
7.	Zacharewski, Timothy R: 18 articles (11/2021 - 12/2004)
8.	Safe, Stephen: 16 articles (01/2020 - 06/2002)
9.	Bruner-Tran, Kaylon L: 15 articles (06/2022 - 07/2005)
10.	Osteen, Kevin G: 15 articles (06/2022 - 07/2005)

Related Diseases

1.	Body Weight (Weight, Body) 10/01/1992 - "The results suggest that a single sublethal dose of TCDD does not alter markedly the general behaviour of Han/Wistar rats, in contrast to its striking effect on feeding behaviour which results in a marked decrease in body weight gain." 01/01/2009 - "The body weight of the 125-ng/kg TCDD group was significantly decreased relative to control and there was also a significant reduction in absolute and relative ovarian weights. " 09/20/1999 - "A repeated dose (5 microg/kg/day for 5 days) of TCDD also resulted in a significant reduction in body weight. " 11/01/1998 - "TCDD caused a reduction in the body weight gain of the dams in both dose groups and a significant reduction in litter size in the higher dose group. " 01/15/2021 - "In this study, female C57BL/6J mice were orally administered three doses of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) (0.1 or 10 μg/kg body weight (bw)) during the pregnancy and lactation periods. "
2.	Neoplasms (Cancer) 01/01/2016 - "In utero and lactational TCDD exposure significantly increased NEPC tumor incidence in TRAMP males, while chronic TCDD treatment in adulthood had the opposite effect, a significant reduction in NEPC incidence. " 02/15/2002 - "A significantly greater decrease in membrane-associated K-ras p21 and increase in total and membrane associated raf-1 occurred in the NDMA/TCDD tumors compared with the NDMA-only tumors. " 01/01/2020 - "Mice in the previous study were genetically prone to prostatic neoplasia and it was therefore unclear whether TCDD exacerbates voiding dysfunction through a malignant or non-malignant mechanism. " 01/15/2013 - "The current study was designed to determine the concentrations and characteristics of PCDD/Fs and evaluate their association with cancer mortality in exposed workers in one automobile foundry factory. " 08/01/2011 - "Results of additional, smaller studies of other occupational groups potentially exposed to TCDD, and of community-based case-control studies, did not provide consistent evidence of an increased cancer risk. "
3.	Atrophy 01/01/2013 - "In the highest dose group (160 µg/Kg), TCDD treatment caused a significant reduction of parasite burdens by 10-fold after three weeks while also causing a significant lymphoid atrophy indicating suppression of the non-protective T helper 2 response. " 04/01/2005 - "Given the rapid clearance of apoptotic cells from the thymus, these histopathologic and cytometric data suggest increased thymocyte apoptosis contributes to fetal thymic atrophy after TCDD exposure." 01/01/1990 - "For example, hypergastrinemia does not develop within the first 48 hr after TCDD administration, and TCDD treatment affords no protection against fasting-induced atrophy of the oxyntic gland mucosa during this time. " 01/01/2019 - "Though our studies demonstrate that TCDD triggers a twofold increase in the frequency of apoptotic thymocytes, TCDD-induced thymic atrophy is not dependent on Fas-FasL interactions, and thus, enhanced apoptosis is unlikely to be a major mechanistic contributor. " 01/01/2019 - "Previous studies suggested that the target for TCDD-induced thymic atrophy resides within the hemopoietic compartment and implicated apoptosis, proliferation arrest of thymic progenitors, and emigration of DN thymocytes to the periphery as potential contributors to TCDD-induced thymic atrophy. "
4.	Edema (Dropsy) 11/01/2004 - "In addition, in TCDD dose response studies the zfarnt2(-/-) embryos showed no protection against three endpoints of TCDD toxicity observed at 96 hpf: pericardial edema, reduced trunk blood flow, and shortened lower jaw. " 09/01/2014 - "In the present study, microscopic analysis with a high-speed camera revealed that TCDD increased the size of a small cavity between the heart and body wall in early eleutheroembryos, a toxic effect that we designate as precardiac edema. " 06/01/2008 - "Mortality, heart rates, edema severity, CYP1A, and regucalcin gene expressions were investigated to study TCDD-induced toxicity in zebrafish during the early life stage. " 07/01/1997 - "Larvae that developed generalized edema were collected at 7 days after the end of TCDD exposure for light and electron microscopic studies. " 03/01/2023 - "TCDD exposure in the early developmental stage of zebrafish embryos led to morphological heart malformation and pericardial edema, concomitant with reduced cardiac function. "
5.	Hydronephrosis 01/31/2019 - "TCDD-induced hydronephrosis, once considered to be caused by the anatomical obstruction of the ureter, is now separated into TCDD-induced obstructive and non-obstructive hydronephrosis, which develops during fetal and neonatal periods, respectively. " 01/01/2019 - "Using this model, we studied TCDD-induced alterations in cPLA2α activation and related factors because of the pivotal roles of cPLA2α both in AHR's nongenomic action and in regulation of causative genes of TCDD-induced hydronephrosis. " 10/01/2014 - "Although these mouse strains possess AhR alleles tightly bound to TCDD, their difference in incidence and severity of hydronephrosis can be explained, in part, by differences in the expression of mPGES-1 and Egr-1. " 10/01/2014 - "Although C57BL/6J and BALB/cA mice harbor AhR receptors highly responsive to TCDD, they were found by chance to differ significantly in the incidence of TCDD-induced hydronephrosis. " 02/10/2014 - "Elucidation of the pathway leading to the onset of hydronephrosis using the TCDD-exposed mouse model will deepen our understanding of the molecular basis of nonobstructive hydronephrosis in humans. "

Related Drugs and Biologics

1.	Polychlorinated Dibenzodioxins (TCDD)
2.	Proteins (Proteins, Gene)
3.	Estrogens (Estrogen)
4.	alpha-Tocopherol
5.	Curcumin
6.	Morpholinos
7.	Polychlorinated Biphenyls (PCBs)
8.	Cytochrome P-450 CYP1A1 (CYP1A1)
9.	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)
10.	Lipids

Related Therapies and Procedures

1.	Intraperitoneal Injections
2.	Drug Therapy (Chemotherapy)
3.	Oral Administration
4.	Adjuvant Chemotherapy
5.	Operative Surgical Procedures