Stromal Interaction Molecule 2

A stromal interaction molecule that functions as a highly sensitive calcium sensor in the ENDOPLAMSIC RETICULUM and CYTOSOL. It can regulate CALCIUM RELEASE ACTIVATED CALCIUM CHANNELS in response to minor variations in intracellular calcium.

Also Known As:

STIM2 Protein

Networked: 12 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Calcium-Binding Proteins: 1333
      - Stromal Interaction Molecules: 31
        Stromal Interaction Molecule 2: 12
        human STIM2 protein
        mouse Stim2 protein
        rat STIM2 protein
        Xenopus Stim2 protein
  - Membrane Proteins: 10078
    - Stromal Interaction Molecules: 31
      - Stromal Interaction Molecule 2: 12
        human STIM2 protein
        mouse Stim2 protein
        rat STIM2 protein
        Xenopus Stim2 protein

Experts

1.	Meng, Xiaojing: 2 articles (04/2022 - 01/2019)
2.	Ayon, Ramon J: 2 articles (01/2020 - 01/2018)
3.	Babicheva, Aleksandra: 2 articles (01/2020 - 01/2018)
4.	Makino, Ayako: 2 articles (01/2020 - 01/2018)
5.	Rodriguez, Marisela: 2 articles (01/2020 - 01/2018)
6.	Song, Shanshan: 2 articles (01/2020 - 01/2018)
7.	Yuan, Jason X-J: 2 articles (01/2020 - 01/2018)
8.	Cai, Shaoxi: 1 article (04/2022)
9.	Deng, Fan: 1 article (04/2022)
10.	Huang, Hui: 1 article (04/2022)

Related Diseases

1.	Myocardial Ischemia (Ischemic Heart Diseases) 09/01/2022 - "This study aimed to explore the mechanism of resveratrol(RES) pretreatment in improving mitochondrial function and alleviating myocardial ischemia-reperfusion(IR) injury by inhibiting stromal interaction molecule 2(STIM2) through microRNA-20 b-5 p(miR-20 b-5 p). "
2.	Colorectal Neoplasms (Colorectal Cancer) 09/01/2012 - "Since stromal interaction molecule 2 (STIM2) is located at 4p15.2 and has been proposed as a candidate gene for this region in glioblastoma multiforme, we aimed at investigating the role of STIM2 in colorectal cancer. " 09/01/2012 - "Stromal interaction molecule 2 (STIM2) is frequently overexpressed in colorectal tumors and confers a tumor cell growth suppressor phenotype." 10/17/2014 - "A reciprocal shift in transient receptor potential channel 1 (TRPC1) and stromal interaction molecule 2 (STIM2) contributes to Ca2+ remodeling and cancer hallmarks in colorectal carcinoma cells."
3.	Neoplasms (Cancer) 10/17/2014 - "In contrast, STIM2 protein was nearly depleted in tumor cells. " 09/01/2012 - "Stromal interaction molecule 2 (STIM2) is frequently overexpressed in colorectal tumors and confers a tumor cell growth suppressor phenotype." 10/17/2014 - "A reciprocal shift in transient receptor potential channel 1 (TRPC1) and stromal interaction molecule 2 (STIM2) contributes to Ca2+ remodeling and cancer hallmarks in colorectal carcinoma cells."
4.	Neoplasm Metastasis (Metastasis) 02/27/2022 - "The results show that STIM2 protein can promote the invasion and metastasis of breast cancer cells through the NFAT1 / TGF-β1 pathway." 01/01/2019 - "Calcium-sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor-β signaling to promote breast cancer metastasis."
5.	Breast Neoplasms (Breast Cancer) 02/27/2022 - "The results show that STIM2 protein can promote the invasion and metastasis of breast cancer cells through the NFAT1 / TGF-β1 pathway." 01/01/2019 - "Calcium-sensing stromal interaction molecule 2 upregulates nuclear factor of activated T cells 1 and transforming growth factor-β signaling to promote breast cancer metastasis."

Related Drugs and Biologics

1.	Resveratrol
2.	Transient Receptor Potential Channels
3.	Calcium
4.	ORAI1 Protein
5.	TRPC Cation Channels
6.	Calcium-Sensing Receptors
7.	Transforming Growth Factors (Transforming Growth Factor)
8.	Serine (L-Serine)
9.	Stromal Interaction Molecule 1