Nogo Receptors

GPI-linked proteins consisting of eight elongated leucine-rich repeats at their N-temini that are connected to the GPI by a "stalk" region rich in prolines, serines and threonines. They bind to NOGO PROTEIN; however, some Nogo receptors also bind MYELIN ASSOCIATED GLYCOPROTEIN and other cell surface glycoproteins. Interactions between Nogo receptors and their ligands modulate nerve growth and NEURONAL PLASTICITY.

Also Known As:

Networked: 84 relevant articles (5 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Strittmatter, Stephen M: 9 articles (01/2020 - 11/2003)
2.	Benowitz, Larry I: 4 articles (01/2017 - 04/2011)
3.	Wang, Xingxing: 3 articles (01/2020 - 11/2006)
4.	Schwab, Martin E: 3 articles (03/2017 - 01/2010)
5.	David, Samuel: 3 articles (11/2008 - 03/2007)
6.	Chao, Feng-Lei: 2 articles (01/2022 - 01/2021)
7.	He, Qi: 2 articles (01/2022 - 01/2021)
8.	Jiang, Lin: 2 articles (01/2022 - 01/2021)
9.	Liang, Xin: 2 articles (01/2022 - 01/2021)
10.	Luo, Yan-Min: 2 articles (01/2022 - 01/2021)

Related Diseases

1.	Optic Neuritis (Retrobulbar Neuritis) 03/01/2017 - "An antibody against a Nogo receptor subunit, leucine rich repeat and immunoglobulin-like domain-containing protein 1 (LINGO-1), was recently shown to improve outcome in patients with acute optic neuritis in a phase II study. " 01/01/2017 - "Understanding the regulation of myelination by oligodendrocytes is therefore critical for developing therapies for the treatment of MS. We previously demonstrated that leucine-rich repeat and Ig-like domain-containing Nogo receptor interacting protein 1 (LINGO-1) is a negative regulator of oligodendrocyte differentiation and that anti-LINGO-1 promotes remyelination in preclinical animal models for MS and in a phase II acute optic neuritis clinical trial (RENEW). "
2.	Ischemic Optic Neuropathy (Anterior Ischemic Optic Neuropathy) 12/01/2021 - "This study evaluates the efficacy of an anti-NOGO receptor antibody in a rat model of NAION, a disorder that currently has no universally-acknowledged treatment." 12/01/2021 - "To evaluate the efficacy and mechanisms of anti-NOGO receptor monoclonal antibody 11C7mAb in a rat model of nonarteritic anterior ischemic optic neuropathy (rNAION). "
3.	Inflammation (Inflammations) 11/01/2008 - "We also discuss how inflammation may be switched off and the recently identified role of the Nogo receptor on activated macrophages in the clearance of these cells from the injured nerve. " 05/01/2018 - "However, the role of nogo receptor in immune cell activation during CNS inflammation is yet to be mechanistically elucidated. " 05/01/2008 - "Novel roles for Nogo receptor in inflammation and disease." 03/01/2007 - "We report a role for Nogo receptors (NgRs) in macrophage efflux from sites of inflammation in peripheral nerve. " 01/01/2017 - "More recently, some degree of regeneration has been achieved through the optic nerve itself by factors associated with intraocular inflammation (oncomodulin) or by altering levels of particular transcription factors (Klf-4, -9, c-myc), cell-intrinsic suppressors of axon growth (PTEN, SOCS3), receptors to cell-extrinsic inhibitors of axon growth (Nogo receptor, LAR, PTP-σ) or the intracellular signaling pathway activated by these receptors (RhoA). "
4.	Disease Progression 12/01/2021 - "Nogo receptor impairs the clearance of fibril amyloid-β by microglia and accelerates Alzheimer's-like disease progression." 08/01/2018 - "On the other side, little progress has been made towards clarifying the role of neurotrophin receptor p75 (p75NTR) and TROY in disease progression, other key players of the Nogo receptor complex. "
5.	Hypoxia (Hypoxemia) 01/01/2021 - "Anti-apoptotic efficacy of Qingnao Yizhi formula in hypoxia/reoxygenation primary cortical neurons through the promotion of synaptic plasticity by modulating the NogoA-Nogo receptor/Rho-Rho kinase signaling pathway."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Leucine (L-Leucine)
3.	rho-Associated Kinases
4.	Amyloid (Amyloid Fibrils)
5.	Alpinia oxyphylla fruit extract
6.	Biocompatible Materials (Biomaterials)
7.	Myelin-Associated Glycoprotein
8.	Myelin Basic Protein
9.	Nogo Receptor 1
10.	Protein Kinases (Protein Kinase)

Related Therapies and Procedures

1.	Electroacupuncture
2.	Therapeutics
3.	Transplantation
4.	Moxibustion