Tenofovir Disoproxil Fumarate Drug Combination Emtricitabine Cobicistat Elvitegravir

A pharmaceutical preparation of the ANTI-HIV AGENTS elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate that is used in the treatment of HIV INFECTIONS.

Also Known As:

Elvitegravir, Cobicistat, Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Disoproxil Fumarate; Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Disoproxil Fumarate Drug Combination; Elvitegravir-Cobicistat-Emtricitabine-Tenofovir Disoproxil Fumarate Drug Combination; Quad Pill; Stribild; Elvitegravir Cobicistat Emtricitabine Tenofovir Disoproxil Fumarate Drug Combination; Pill, Quad; Genvoya

Networked: 17 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bartiaux, Magali: 1 article (01/2021)
2.	Bédoret, Floriane: 1 article (01/2021)
3.	De Wit, Stéphane: 1 article (01/2021)
4.	Gilles, Christine: 1 article (01/2021)
5.	Libois, Agnes: 1 article (01/2021)
6.	Malinverni, Stefano: 1 article (01/2021)
7.	Epstein, Eric J: 1 article (09/2020)
8.	Mathias, Priyanka M: 1 article (09/2020)
9.	Ba, Selly: 1 article (10/2018)
10.	Faye, Khadim: 1 article (10/2018)

Related Diseases

1.	Infections 01/01/2014 - "The quad pill is the newest single-pill, once-daily option for the treatment of human immunodeficiency virus (HIV) type 1 infection. " 10/30/2018 - "A Trial of a Single-tablet Regimen of Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Disoproxil Fumarate for the Initial Treatment of Human Immunodeficiency Virus Type 2 Infection in a Resource-limited Setting: 48-Week Results From Senegal, West Africa." 12/01/2012 - "Stribild contains complete antiretroviral therapy for HIV-1 infection in a single tablet. " 12/01/2012 - "Stribild is the first single-tablet regimen for HIV-1 infection treatment containing an integrase inhibitor. " 06/30/2012 - "Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3, non-inferiority trial."
2.	Muscular Diseases (Myopathy) 12/01/2022 - "Genvoya-Associated and Simvastatin-Associated Noninflammatory and Nonautoimmune Myopathy: A Case Report and Literature Review." 12/01/2022 - "In this study, we describe a case of biopsy-proven noninflammatory and nonautoimmune myopathy associated with the use of simvastatin and Genvoya (elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide fumarate) and review 3 previously reported similar cases. "
3.	Insulin Resistance 01/01/2016 - "Neither boosted elvitegravir nor darunavir with emtricitabine/tenofovir disoproxil fumarate increase insulin resistance in healthy volunteers: results from the STRIBILD-IR study."
4.	HIV Infections (HIV Infection) 01/01/2014 - "The quad pill, a once-daily combination therapy for HIV infection." 06/01/2016 - "We describe a case of tacrolimus toxicity due to supratherapeutic tacrolimus concentrations when Stribild (elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate) was initiated for newly diagnosed HIV infection in a 50-year-old renal transplant recipient who was previously receiving a stable tacrolimus regimen. " 11/01/2013 - "Prominent in the current stage of antiviral drug development are: (i) for human immunodeficiency virus (HIV), the use of fixed-dose combinations (FDCs), the most recent example being Stribild(TM); (ii) for hepatitis C virus (HCV), the pleiade of direct-acting antivirals (DAAs) that should be formulated in the most appropriate combinations so as to obtain a cure of the infection; (iii)-(v) new strategies (i.e., AIC316, AIC246, and FV-100) for the treatment of herpesvirus infections: herpes simplex virus (HSV), cytomegalovirus (CMV), and varicella-zoster virus (VZV), respectively; (vi) the role of a new tenofovir prodrug, tenofovir alafenamide (TAF) (GS-7340) for the treatment of HIV infections; (vii) the potential use of poxvirus inhibitors (CMX001 and ST-246); (viii) the usefulness of new influenza virus inhibitors (peramivir and laninamivir octanoate); (ix) the position of the hepatitis B virus (HBV) inhibitors [lamivudine, adefovir dipivoxil, entecavir, telbivudine, and tenofovir disoproxil fumarate (TDF)]; and (x) the potential of new compounds such as FGI-103, FGI-104, FGI-106, dUY11, and LJ-001 for the treatment of filoviruses (i.e., Ebola). "
5.	Headache (Headaches) 06/01/2016 - "The patient reported headache, insomnia, stomachache, and decreased urine output within 1 week of starting Stribild and was found to have acute kidney injury (serum creatinine [Scr ]concentration increasing from 1.5-2.3 mg/dl) and a serum tacrolimus concentration of 111.2 ng/ml at 1 week follow-up (goal trough level 4-6 ng/ml). " 01/01/2017 - "The most common side effects reported by Quad pill users were as follows: abdominal discomfort or pain, gas or bloating (42%), diarrhea (38%), fatigue (28%), nausea or vomiting (28%), headache (14%), or dizziness or lightheadedness (6%). "

Related Drugs and Biologics

1.	elvitegravir
2.	Tenofovir (Viread)
3.	Emtricitabine (Emtriva)
4.	Tablets
5.	Cobicistat
6.	Simvastatin (Zocor)
7.	Fumarates
8.	Darunavir (Prezista)
9.	emtricitabine tenofovir alafenamide
10.	Antiviral Agents (Antivirals)

Related Therapies and Procedures

1.	Therapeutics