Tenofovir (Viread)

An adenine analog REVERSE TRANSCRIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used alone.

Also Known As:

Viread; (R)-9-(2-phosphonylmethoxypropyl)adenine; 9-(2-Phosphonomethoxypropyl)adenine; 9-(2-Phosphonylmethoxypropyl)adenine; 9-(2-Phosphonylmethoxypropyl)adenine, (+-)-isomer; 9-(2-Phosphonylmethoxypropyl)adenine, (R)-isomer - T357098; 9-(2-Phosphonylmethoxypropyl)adenine, (S)-isomer; 9-PMPA (tenofovir); Tenofovir Disoproxil; Tenofovir Disoproxil Fumarate; Disoproxil Fumarate, Tenofovir; Disoproxil, Tenofovir; Fumarate, Tenofovir Disoproxil

Networked: 2723 relevant articles (310 outcomes, 463 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Buti, Maria: 34 articles (01/2022 - 12/2008)
2.	Ahn, Sang Hoon: 31 articles (02/2022 - 09/2014)
3.	Flaherty, John F: 27 articles (01/2022 - 01/2004)
4.	De Clercq, Erik: 27 articles (12/2021 - 11/2002)
5.	Marcellin, Patrick: 27 articles (10/2019 - 03/2007)
6.	Lim, Young-Suk: 26 articles (01/2022 - 01/2016)
7.	Kim, Seung Up: 24 articles (01/2022 - 09/2014)
8.	Lampertico, Pietro: 24 articles (01/2022 - 03/2012)
9.	Chen, Chien-Hung: 23 articles (02/2022 - 01/2015)
10.	Kim, Beom Kyung: 23 articles (01/2022 - 09/2014)

Related Diseases

1.	Chronic Hepatitis B 08/01/2013 - "Efficacy of tenofovir disoproxil fumarate at 240 weeks in patients with chronic hepatitis B with high baseline viral load." 12/01/2012 - "This study evaluated the safety and efficacy of tenofovir DF in adolescents with chronic hepatitis B (CHB). " 08/14/2007 - "To study the efficacy of tenofovir disoproxil fumarate (TDF) at low dose in a small open trial of chronic hepatitis B patients with advanced stage disease. " 12/01/2020 - "The safety and efficacy of tenofovir disoproxil fumarate used throughout pregnancy for mothers with chronic hepatitis B." 10/01/2019 - "Tenofovir disoproxil fumarate (TDF) is a first-line treatment for chronic hepatitis B (CHB). "
2.	Infections 02/01/2000 - "In previous studies, we demonstrated that 9-¿2-(R)-(phosphonomethoxy)propylădenine (PMPA; tenofovir) was highly effective in protecting newborn macaques against infection with virulent wild-type (i.e., drug-susceptible) SIVmac251. " 06/01/2017 - "With its potential for an improved safety profile, tenofovir AF is an important emerging first-line option for the treatment of chronic HBV infection in adults and adolescents (aged ≥12 years and with a bodyweight of ≥35 kg)." 10/19/2018 - "Efficacy of tenofovir in preventing perinatal transmission of HBV infection in pregnant women with high viral loads." 10/01/2018 - "Tenofovir, category B drug, is more effective in preventing transmission of HBV infection to infants (p = 0.004)." 11/01/2017 - "It is more stable than tenofovir disoproxil fumarate (TDF) in the plasma and can provide similar efficacy with lower circulating concentration in patients with hepatitis B virus (HBV) infection. "
3.	HIV Infections (HIV Infection) 03/01/2012 - "Topical tenofovir gel has proven effective in the prevention of HIV infection in women in South Africa. " 12/01/2017 - "Preexposure prophylaxis (PrEP) with tenofovir disoproxil fumarate (TDF)-based regimens has been shown to be effective in preventing acquisition of HIV infection, with protective efficacy being dependent on adherence to treatment. " 07/01/2013 - "Tenofovir (TFV) is a widely used and effective treatment for HIV infection. " 01/01/2012 - "Tenofovir is widely used as first-line treatment of HIV infection, although its use is sometimes complicated by a reversible proximal renal tubulopathy.We" 01/01/2018 - "To determine whether this heterogeneity could influence patient outcomes following PrEP, we undertook a post hoc prospective analysis of results from the CAPRISA 004 trial for 1% tenofovir gel (n = 774 patients), one of the first trials to demonstrate protection against HIV infection. "
4.	Hepatitis B 07/01/2019 - "The optimal management of chronic hepatitis B (CHB) patients with partial virologic response (PVR) to tenofovir disoproxil fumarate (TDF) remains unclear. " 01/01/2009 - "New approaches in the management of chronic hepatitis B: role of tenofovir." 01/01/2021 - "Hepatitis B reactivation after tenofovir withdrawal in an HIV-infected patient with history of cured hepatitis B virus infection and poor immunological status." 01/01/2023 - "The Hepatitis B Research Network Immune-Active Trial evaluated treatment with tenofovir (TDF) for 4 years ± an initial 6 months of peginterferon-α (PegIFN) (NCT01369212) after which treatment was withdrawn. " 01/01/2019 - "There are few studies on the effects of tenofovir in patients with mono hepatitis B. "
5.	Fibrosis (Cirrhosis) 01/01/2007 - "The safety and efficacy of tenofovir in HIV/HBV cirrhosis has not been previously described. " 11/01/2020 - "Long-term suppression of hepatitis B virus with tenofovir (TDF) induces fibrosis regression, and repeated liver stiffness (LS) measurement can indicate the improvement of fibrosis. " 01/01/2020 - "Tenofovir for the Prevention of HCC in Patients With Cirrhosis." 10/01/2019 - "In conclusion, this report shows excellent safety and effectiveness of a 48-week course of MyrB 10 mg/day, combined with tenofovir disoproxil fumarate, for the treatment of HDV-related compensated cirrhosis." 01/01/2019 - "Findings were sensitive to age, discount rate, health state utility in immune or susceptible stages, progression rate to cirrhosis or inactive disease, and tenofovir cost. "

Related Drugs and Biologics

1.	entecavir
2.	Emtricitabine (Emtriva)
3.	Lamivudine (Epivir)
4.	adefovir
5.	tenofovir alafenamide
6.	Tenofovir (Viread)
7.	Antiviral Agents (Antivirals)
8.	Racivir
9.	Hepatitis B e Antigens
10.	lipoarabinomannan (LAM)

Related Therapies and Procedures

1.	Therapeutics
2.	Liver Transplantation
3.	Highly Active Antiretroviral Therapy (HAART)
4.	Art Therapy
5.	Drug Therapy (Chemotherapy)