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Muscular Diseases (Myopathy)

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Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.

Also Known As:

Myopathy; Myopathies; Myopathic Conditions; Muscle Disorder; Muscular Disease; Myopathic Condition; Muscle Disorders

Networked: 5014 relevant articles (96 outcomes, 362 trials/studies) for this Disease, Comments

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Polymyositis
2.	Muscular Dystrophies (Muscular Dystrophy)
3.	Muscle Weakness
4.	Body Weight (Weight, Body)
5.	Osteomalacia

Experts

1.	Nishino, Ichizo: 21 articles (11/2012 - 05/2002)
2.	Muntoni, Francesco: 15 articles (06/2012 - 10/2002)
3.	Ferreiro, Ana: 13 articles (04/2012 - 10/2002)
4.	Vicart, Patrick: 13 articles (03/2010 - 06/2002)
5.	DiMauro, Salvatore: 12 articles (10/2012 - 09/2002)
6.	Goldfarb, Lev G: 12 articles (08/2012 - 03/2003)
7.	Jungbluth, Heinz: 12 articles (06/2012 - 10/2002)
8.	Bönnemann, Carsten G: 12 articles (02/2012 - 06/2002)
9.	Goebel, Hans H: 11 articles (11/2010 - 06/2002)
10.	North, Kathryn N: 11 articles (10/2010 - 01/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Muscular Diseases:

1.	SeleniumIBA 01/01/1985 - "A preliminary study on selenium content of forages and local by-products in the Tadla area (Morocco) in connection with ovine nutritional myopathy." 12/01/2012 - "Low serum selenium concentrations are common in hospitalised adult horses while nutritional myopathy is rare in these animals." 12/01/2012 - "No associations were identified between nutritional myopathy and selenium status in horses between 30 days and 2 years of age or in horses more than 2 years of age. " 12/01/2012 - "There was an association between low selenium and myopathy in the <30-day-old animals (P = 0.017), all of which were classified as having WMD. " 10/01/2011 - "Selenium status at the end of the grazing season, reproductive performance and degenerative myopathy in beef herds." Order ALL the reference details at left...
2.	Zidovudine (Retrovir)FDA LinkGeneric 07/01/2010 - "Zidovudine myopathy may be a constraint for use of the drug in the western population; however, it is a well-tolerated drug as regards myopathy in our study on Indian patients." 07/01/2010 - "Literature is replete with studies on zidovudine-induced myopathy after prolonged use (use beyond 270 days on an average). " 07/01/2010 - "Zidovudine-induced myopathy: A study in Indian patients." 03/01/1997 - "Analysis of myopathy in a placebo-controlled zidovudine trial." 10/01/1992 - "The aim of this study was to evaluate the frequency of appearance of myopathy in a group of patients treated with zidovudine. " Order ALL the reference details at left...
3.	Prednisone (Sone)FDA LinkGeneric 01/01/1996 - "The results of this study suggested that the significant improvement in exercise capacity observed after this short-term endurance training period may have arisen mainly through peripheral mechanisms, associated with the possible decrease in plasma catecholamine concentrations and reversal of muscle deconditioning and/or prednisone-induced myopathy." 07/01/1985 - "Evidence that prednisone-induced myopathy is reversed by physical training." 08/01/1972 - "Lipid storage myopathy responsive to prednisone." 12/01/1980 - "Marked improvement in the myopathy occurred after commencement of prednisone and thiamine and was maintained following withdrawal of these drugs. " 07/01/1984 - "Oral steroids, 40 to 80 mg prednisone daily, were moderately effective in reducing progressive soft tissue inflammatory signs, but were less effective in controlling myopathy and lid retraction. " Order ALL the reference details at left...
4.	Prednisolone (Predate)FDA LinkGeneric 12/01/2003 - "This report describes a case of acute steroid-induced myopathy following a single dose of oral prednisolone. " 12/01/2003 - "Steroid-induced myopathy following a single oral dose of prednisolone." 08/01/1993 - "Finally, 90 min daily of endurance exercise did not antagonize prednisolone-induced myopathy in either the diaphragm or the plantaris." 08/01/1985 - "Progressive diaphyseal dysplasia mimicking childhood myopathy: clinical and biochemical response to prednisolone." 01/01/1979 - "[Pathogenetic therapy of nervous system and muscular diseases using large doses of prednisolone on alternate days]." Order ALL the reference details at left...
5.	I-antigenIBA 11/01/1993 - "The myopathy caused by HIV and HTLV-1 is not due to direct infection of the muscle by these viruses, but rather due to an immunopathologic process triggered by the viruses, mediated by autoaggressive CD8+ cells in the context of MHC-class I antigen expression. " 03/01/1989 - "Major histocompatibility complex class I antigen expression, immunolocalization of interferon subtypes, and T cell-mediated cytotoxicity in myopathies." 04/19/1990 - "We conclude that long-term therapy with zidovudine can cause a toxic mitochondrial myopathy, which coexists with a T-cell-mediated inflammatory myopathy that is restricted to MHC-I antigen, and is indistinguishable from the myopathy associated with primary HIV infection or polymyositis in HIV-seronegative patients." 01/01/1997 - "Immunohistology for major histocompatibility complex class I antigen and histochemical reaction for cytochrome coxidase are helpful in the correct classification of a myopathy as HIV polymyositis or zidovudine myopathy." 11/01/1995 - "Immunohistology for major histocompatibility complex class I antigen and histochemical reaction for cytochrome c oxidase are helpful in correct classification of a myopathy as HIV polymyositis or zidovudine myopathy." Order ALL the reference details at left...
6.	Pravastatin (Pravachol)FDA LinkGeneric 02/01/2009 - "The present study suggests that changes in the OATP1B1 activities may have a small and a large impact on the therapeutic efficacy and side effect (myopathy) of pravastatin, respectively, whereas those in the MRP2 activities may have opposite impacts (i.e., large and small impacts on the therapeutic efficacy and side effect)." 12/01/2010 - "Therefore, variation in the OATP1B1 activities will have small and large impacts on the therapeutic efficacy and adverse effect (myopathy) of pravastatin, respectively, whereas that affecting the MRP2 activities may have an opposite effect (i.e., large and small impacts on the therapeutic efficacy and side effect). " 06/01/2009 - "In the present study, we analyzed the function of a novel mutation (c.1628T>G, p.Leu543Trp) in the solute carrier organic anion transporter (SLCO) 1B1 gene, encoding organic anion transporting polypeptide (OATP) 1B1, which was identified in a patient with pravastatin-induced myopathy. " 07/01/2005 - "Object of the present study was to study the influence of SLCO1B15, 15 and 15+C1007G, a novel haplotype found in a patient with pravastatin-induced myopathy, on the functional properties of OATP1B1 by transient expression systems of HEK293 and HeLa cells using endogenous conjugates and statins as substrates. " 06/01/2009 - "Functional analysis of a mutation in the SLCO1B1 gene (c.1628T>G) identified in a Japanese patient with pravastatin-induced myopathy." Order ALL the reference details at left...*
7.	Carnitine (L-Carnitine)FDA LinkGeneric 01/01/1984 - "The latter was treated successfully with oral carnitine but the myopathy persisted. " 10/01/1982 - "We suggest that some cases of idiopathic lipid storage myopathy may be safely and effectively treated with carnitine and medium-chain triglyceride diet." 01/01/1988 - "Although the primary metabolic defect has yet to be elucidated, the present study indicates that lipid storage myopathy in the absence of carnitine deficiency can be complicated with RS-like episodes." 03/30/1986 - "[Carnitine-deficient myopathy successfully treated with bicarnesine; clinico-chemical and muscle morphology studies]." 06/01/2011 - "This finding suggested that L-carnitine could be recommended in the management of post-menopausal myopathy." Order ALL the reference details at left...
8.	Adrenal Cortex Hormones (Corticosteroids)IBA 02/01/1985 - "High-dose corticosteroids were dramatically effective in inducing remission, with resolution of all signs and symptoms of the myopathy and normalization of CPK." 08/01/2000 - "These improved initially with more frequent infusions of hdIVIg but oral corticosteroids were required to treat worsening myopathy. " 12/01/1996 - "A MEDLINE search (1985 to July 1995, English language) yielded case reports and clinical studies involving myopathy or weakness associated with the use of NMBAs and/or corticosteroids. " 04/01/1995 - "The present study was designed to evaluate the ability of specific inspiratory muscle training (SIMT) to prevent the effects of a therapeutic dosage of corticosteroids on inspiratory muscle function in patients receiving the drug for diseases other than pulmonary, with no underlying respiratory or muscular disease. " 01/01/2011 - "Acute myopathy caused by exogenous corticosteroids is rare, usually with intravenous corticosteroids at high doses. " Order ALL the reference details at left...
9.	Electron Transport Complex IV (Cytochrome c Oxidase)IBA 03/01/1992 - "Morphological studies failed to show ragged-red fibers but there was lipid storage myopathy and decreased cytochrome c oxidase activity. " 01/01/1991 - "In the fatal infantile myopathy due to cytochrome c oxidase (COX) deficiency, an autosomal recessive condition, immunocytochemical studies have shown an isolated defect of subunit VIIa, which is 1 of the only 2 tissue-specific subunits of human COX. " 02/01/2001 - "Skeletal muscle showed severe degenerating myopathy found to be full of ragged-red fibers (RRFs), an increased number of lipid droplets, and severe cytochrome c oxidase (COX) deficiency. " 07/01/2000 - "Cytochrome c oxidase (COX) deficiency is an important cause of myopathy or encephalomyopathy. " 10/01/1999 - "A missense mutation of cytochrome oxidase subunit II causes defective assembly and myopathy." Order ALL the reference details at left...
10.	Immunosuppressive Agents (Immunosuppressants)IBA 03/29/2011 - "These data suggest that MMF is effective in CNS sarcoidosis but not in sarcoid myopathy, with a corticosteroid sparing effect and a better tolerance profile than other immunosuppressive agents." 04/01/2011 - "On the other hand, acquired (and treatable with immunosuppressants) necrotizing myopathies with anti-SRP antibodies can be very slowly progressive, with clinical and pathological features compatible with limb girdle dystrophies. " 02/01/2010 - "We report patients from two neuromuscular centers who were evaluated between the years 2000 and 2008 and met the following criteria: (1) proximal muscle weakness occurring during or after treatment with statins; (2) elevated serum creatine kinase (CK); (3) persistence of weakness and elevated CK despite discontinuation of the statin; (4) improvement with immunosuppressive agents; and (5) muscle biopsy showing necrotizing myopathy without significant inflammation. " 02/01/2007 - "One patient had acute sarcoid myositis and benefited from methotrexate; other immunosuppressants and etanercept proved ineffective in chronic sarcoid myopathy. " 05/01/2004 - "However, interaction of immunosuppressants with HMG CoA inhibitors, which are metabolized by cytochrome P 450, increase incidence of skeletal muscle myopathy and rhabdomyolysis." Order ALL the reference details at left...

Therapies and Procedures

1.	Plasma Exchange 10/01/2012 - "[Necrotizing myopathy associated with anti-SRP auto-antibodies: transient efficacy of a therapeutic strategy associating plasma exchanges and rituximab]." 05/01/2006 - "We report two patients with myopathy associated with anti-signal recognition particle Ab, refractory to conventional therapy, who were treated with prednisone and plasma exchange, followed by rituximab. " 05/01/2006 - "Marked efficacy of a therapeutic strategy associating prednisone and plasma exchange followed by rituximab in two patients with refractory myopathy associated with antibodies to the signal recognition particle (SRP)." Order ALL the reference details at left...
2.	Denervation 08/01/1978 - "For the diagnosis of denervation the most useful measurement was that of potential duration; for the detection of myopathies amplitude determinations were also very useful. " 08/01/2002 - "In skeletal muscle, very few studies have been done under specific physiological (e.g., exercise) and pathophysiological (e.g., dystrophies, denervation, myopathies) conditions. " 03/01/2001 - "This study demonstrates that inclusion body myopathy is identifiable in patients with STC and that it may arise secondary to denervation." 09/09/1966 - "Histochemical studies on denervation, chemically induced and hereditary forms of myopathies." 12/01/2010 - "This last conclusion seems to have a significant relevance in understanding the mechanisms involved in muscle disorders, denervation and chronic muscle disuse, conditions frequently characterized by a decline in mitochondrial content and by an increase of mitochondrial apoptosis susceptibility." Order ALL the reference details at left...
3.	Transplantation (Transplant Recipients) 05/15/2005 - "The purpose of this study was to determine the efficacy of resistance exercise in reversing skeletal muscle myopathy in heart transplant recipients. " 01/01/2012 - "Transplantation of muscle precursor cells is of therapeutic interest for focal skeletal muscular diseases. " 08/01/2009 - "The development of muscle stem cells for transplantation or gene transfer in patients with muscle disorders has become more attractive and challenging recently. " 08/27/2006 - "Transfection of IGFII gene into ES cells may be applicable for transplantation therapy of muscle damage due to injury and myopathies." 05/15/2005 - "Effect of resistance exercise on skeletal muscle myopathy in heart transplant recipients." Order ALL the reference details at left...
4.	Artificial Respiration (Mechanical Ventilation) 10/01/2010 - "Clinical consequences (and/or often causes) of prolonged mechanical ventilation comprise features such as myopathy, neuropathy, and body composition alterations and depression, which increase the costs, morbidity and mortality of this. " 10/01/2009 - "One patient required prolonged mechanical ventilation due to a severe myopathy during the post operative course, but there were no complications or deaths. " 01/01/2009 - "Patients with postoperative complications (mechanical ventilation, major myopathy) were excluded. " 01/01/2005 - "Myopathy was associated with prolonged mechanical ventilation and in-hospital stay." 01/01/2005 - "Myopathy is associated with an increase in the duration of mechanical ventilation [15.4 (9.2) versus 5.7 (3.9) days; p<0.006], the length of ICU stay [23.6 (10.7) versus 11.4 (7.05) days; p<0.003] and hospital stay [33.3 (19.2) versus 21.2 (16.1) days; p<0.034)]. " Order ALL the reference details at left...
5.	Aftercare (After-Treatment) 07/01/2009 - "Hypothyroid dogs developed electromyographic and morphologic evidence of myopathy by 6 months after treatment, which persisted throughout the study, although these changes were subclinical at all times. " 11/01/1966 - "[Hypothyroid myopathies: optic and electron microscopic study before and after treatment]." 09/01/2012 - "Exercise genes may provide a new opportunity for studying the outcome after treatment and the muscle regeneration abilities in other models of genetic myopathies." 08/01/1998 - "P100 latency of the PR-VEPs in MG patients before and after treatment was delayed compared to normal controls, while there were no differences between ocular myopathy patients and normal controls. " 01/01/1994 - "Mitochondrial changes in acute myopathy after treatment of respiratory failure with mechanical ventilation (acute relaxant-steroid myopathy)." Order ALL the reference details at left...

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