Type V Secretion Systems

Secretion systems of GRAM-NEGATIVE BACTERIA (single membrane proteins or multiprotein complexes) that carry out secretion of proteins from the PERIPLASMIC SPACE to the EXTRACELLULAR SPACE via a beta-barrel transmembrane pore. There are several T5SS subtypes: T5aSS monomeric autotransporters, T5bSS two-partner secretions systems (TPSS), T5cSS trimeric autotransporters, T5dSS fused two-partner secretion systems, and T5eSS autotransporters with inverted domains.

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Networked: 103 relevant articles (4 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Miller, Virginia L: 4 articles (08/2013 - 01/2009)
2.	Fleckenstein, James M: 3 articles (01/2022 - 12/2011)
3.	Hogan, Robert J: 3 articles (04/2019 - 01/2015)
4.	Lafontaine, Eric R: 3 articles (04/2019 - 01/2015)
5.	Michel, Frank: 3 articles (04/2019 - 01/2015)
6.	Rasko, David A: 3 articles (01/2018 - 01/2004)
7.	Clark, Tina R: 3 articles (01/2017 - 02/2008)
8.	Hackstadt, Ted: 3 articles (01/2017 - 02/2008)
9.	Lenz, Jonathan D: 3 articles (08/2013 - 01/2009)
10.	Lawrenz, Matthew B: 3 articles (07/2013 - 01/2009)

Related Diseases

1.	Infections 09/01/2017 - "Protective effects of in vivo-expressed autotransporters against Bordetella pertussis infection." 11/01/2011 - "SadA, a trimeric autotransporter from Salmonella enterica serovar Typhimurium, can promote biofilm formation and provides limited protection against infection." 03/24/2011 - "Immunogenicity and protection against Haemophilus parasuis infection after vaccination with recombinant virulence associated trimeric autotransporters (VtaA)." 12/01/2011 - "Recent immunoproteomic studies suggesting that multiple autotransporter passenger domains are recognized during ETEC infection prompted the present studies. " 06/01/2023 - "Immunization with autotransporter Vag8 prevents coughing induced by Bordetella pertussis infection in mice."
2.	Diarrhea 10/01/2010 - "The adhesin involved in diffuse adherence (AIDA-I) is an autotransporter found in pathogenic strains of Escherichia coli causing diarrhea in humans and pigs. " 01/01/2001 - "The AIDA autotransporter system is associated with F18 and stx2e in Escherichia coli isolates from pigs diagnosed with edema disease and postweaning diarrhea." 01/01/2021 - "Frequency of serine protease autotransporters of enterobacteriaceae (SPATE) encoding genes in diffusely adherent escherichia coli (DAEC) isolates from children with and without diarrhea." 02/01/2012 - "The gene encoding the autotransporter protease SepA, originally described in Shigella species, was most strongly associated with diarrhea among the EAEC strains tested (odds ratio, 5.6 [95% confidence interval, 1.92-16.17]; P = .0006). " 01/01/2007 - "[The presence and polymorphism of genes encoding serine protease autotransporters (spate) among the Escherichia coli isolated in the region of Gdansk from children with diarrhea]."
3.	Melioidosis 02/07/2022 - "The autotransporter protein Burkholderia intracellular motility A (BimA) facilitates the entry of Burkholderia pseudomallei into the central nervous system (CNS) in mouse models of melioidosis. " 03/15/2007 - "Burkholderia Hep_Hag autotransporter (BuHA) proteins elicit a strong antibody response during experimental glanders but not human melioidosis." 01/01/2015 - "In a systematic study of these autotransporters, we constructed insertion mutants in each gene predicted to encode an autotransporter and assessed them for three pathogenesis-associated phenotypes: virulence in the BALB/c intra-peritoneal mouse melioidosis model, net intracellular replication in J774.2 murine macrophage-like cells and survival in 45% (v/v) normal human serum. " 01/01/2013 - "As part of a larger systematic study on the autotransporters of Burkholderia pseudomallei, the causative agent of the severe tropical disease melioidosis, we have constructed an insertion mutant in the bpss1439 gene encoding an unstudied predicted trimeric autotransporter adhesin. " 11/01/2015 - "The 1.8 Å resolution crystal structure of a conserved domain of the potential Burkholderia pseudomallei antigen and trimeric autotransporter BPSL2063 is presented as a structural vaccinology target for melioidosis vaccine development. "
4.	Stomach Neoplasms (Stomach Cancer) 04/09/2013 - "In this study, we analyzed three autotransporter proteins (VacA-like proteins) produced by Helicobacter pylori, a Gram-negative bacterium that colonizes the human stomach and contributes to the pathogenesis of gastric cancer and peptic ulcer disease. " 10/09/2007 - "Helicobacter pylori VacA, a pore-forming toxin secreted by an autotransporter pathway, causes multiple alterations in human cells, contributes to the pathogenesis of peptic ulcer disease and gastric cancer, and is a candidate antigen for inclusion in an H. "
5.	Peptic Ulcer (Peptic Ulcers) 04/09/2013 - "In this study, we analyzed three autotransporter proteins (VacA-like proteins) produced by Helicobacter pylori, a Gram-negative bacterium that colonizes the human stomach and contributes to the pathogenesis of gastric cancer and peptic ulcer disease. " 10/09/2007 - "Helicobacter pylori VacA, a pore-forming toxin secreted by an autotransporter pathway, causes multiple alterations in human cells, contributes to the pathogenesis of peptic ulcer disease and gastric cancer, and is a candidate antigen for inclusion in an H. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Antigens
3.	pertactin
4.	Flagellin
5.	endoxo-delta(4)-tetrahydrophthalic acid
6.	Type V Secretion Systems
7.	Serine Proteases (Serine Protease)
8.	Virulence Factors (Pathogenicity Factors)
9.	Vaccines
10.	Aerosols