Interleukin-33

A member of the INTERLEUKIN-1 protein family involved in the maturation of TH2 CELLS and the activation of MAST CELLS; BASOPHILS; EOSINOPHILS and NK CELLS. It is also produced by ENDOTHELIAL CELLS; EPITHELIAL CELLS and FIBROBLASTS; where it can function as an alarmin to modulate immune and inflammatory responses to tissue damage.

Also Known As:

Networked: 2699 relevant articles (116 outcomes, 492 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nakae, Susumu: 37 articles (01/2022 - 11/2008)
2.	Saito, Hirohisa: 33 articles (01/2021 - 11/2008)
3.	Liew, Foo Y: 33 articles (12/2018 - 02/2008)
4.	Girard, Jean-Philippe: 30 articles (01/2022 - 01/2007)
5.	Xu, Damo: 23 articles (01/2020 - 02/2008)
6.	McKenzie, Andrew N J: 22 articles (01/2022 - 06/2007)
7.	Matsumoto, Kenji: 22 articles (01/2021 - 11/2008)
8.	Ryffel, Bernhard: 20 articles (01/2021 - 05/2011)
9.	Gangemi, Sebastiano: 17 articles (03/2022 - 03/2013)
10.	Kita, Hirohito: 17 articles (01/2021 - 06/2008)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2018 - "Importantly, exogenous IL-33 abrogated the protective effects of Ad5-gsgAM, revealing that the suppression of IL-33/ST2 axis substantially contributed to protection against allergic inflammation. " 01/01/2019 - "IL-33 Ameliorates the Development of MSU-Induced Inflammation Through Expanding MDSCs-Like Cells." 09/01/2017 - "Cadherin-11-deficient mice displayed increased stromal production of IL-33, with concomitant enhancements in ILC2s and M2 macrophages that helped control adipose tissue inflammation. " 12/05/2016 - "Taken together, these results suggest that AS-IV effectively ameliorates the progression of allergic inflammation by inhibiting key initiating factors, including TSLP and IL-33, and can be used to prevent and/or treat patients with ACD. " 09/27/2023 - "Recent studies have shown that IL-33, which triggers inflammation, and IL-37, which suppresses it, cooperatively regulate the balance between inflammation and anti-inflammation. "
2.	Asthma (Bronchial Asthma) 09/20/2023 - "(4) Cross-validation of the combined indicators showed that IL-33 significantly improved asthma diagnostic efficacy. " 10/01/2023 - "Our findings suggest that IL-33 blockade ameliorates the severity of an asthma exacerbation by attenuating neutrophil recruitment and the downstream generation of NETs." 10/01/2020 - "ORMDL3 overexpression helped airway epithelial cellrepairin asthma via regulating IL-33 expression." 01/01/2023 - "However, we also noticed that there were no significant differences of IL-33 levels between controls and asthma patients in a recent study. " 01/01/2023 - "Clinical trials blocking IL-33 and its receptor ST2 have also shown improvements in lung function and exacerbation rates; however, the impact of blocking the IL-33/ST2 axis in T2-high versus T2-low asthma is unclear. "
3.	Infections 02/01/2018 - "It has been reported that IL-33 contributes to potentiation of Th2 inflammatory diseases and protection against helminth infection. " 01/01/2022 - "In this study, we found increased mouse IL-33 expression in CD8+ T cells following cell activation via anti-CD3/CD28 stimulation in vitro or lymphocytic choriomeningitis virus (LCMV) infection in vivo. " 01/01/2021 - "Some studies have reported an increase in IL-33 during helminth infections, including T. " 04/01/2020 - "Growing studies imply that IL-33 is involved in host defense against microbial infection. " 01/01/2020 - "In this study, we found that the expression of IL-33 in mice liver was significantly induced by H. hepaticus infection at 24 weeks post infection (WPI). "
4.	Neoplasms (Cancer) 01/15/2022 - "Although separate blockage of either IL33/ST2 or PD-L/PD-1 axes has been shown to be beneficial in many tumors, co-blockage of IL33/ST2 and PD-L/PD-1 hasn't been studied yet. " 01/01/2020 - "Herein, we discuss the contradictory role of IL-33 in immune cells in different cancer, and our summaries may be helpful for better understanding of the development of research on IL-33 and tumor immunity." 11/01/2020 - "Mechanistically, IL33 increased the accumulation and effector function of tumor-resident CD103+CD8+ T cells, and CD103 expression on CD8+ T cells was required for the antitumor efficacy of IL33. " 11/01/2020 - "We demonstrated that tumor-derived IL33 was crucial for the antitumor efficacy of checkpoint inhibitors. " 01/01/2021 - "In this study, we demonstrate the potent antitumor effects of IL-33 using syngeneic mouse models, which included marked inhibition of tumor growth and upregulation of IFN-γ production by tumor-infiltrating CD8+ T cells. "
5.	Colitis 01/01/2019 - "IL-33 ameliorates experimental colitis involving regulation of autophagy of macrophages in mice." 12/01/2013 - "Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in mice." 07/18/2012 - "Interleukin-33 ameliorates experimental colitis through promoting Th2/Foxp3⁺ regulatory T-cell responses in mice." 02/01/2020 - "Although IL-33 expression is increased in IBD patients and correlates with the patients' disease activity index, mechanistic studies to date have demonstrated both pathogenic and protective roles in animal models of experimental colitis. " 10/02/2018 - "Although IL-33 and its receptor ST2/ILRL1 are known to be increased and associated with IBD, studies using animal models of colitis to address the mechanism have yielded ambiguous results, suggesting both pathogenic and protective functions. "

Related Drugs and Biologics

1.	Cytokines
2.	Interleukin-13
3.	Interleukin-4 (Interleukin 4)
4.	Alarmins
5.	Interleukin-6 (Interleukin 6)
6.	Interleukin-10 (Interleukin 10)
7.	Interleukin-17 (Interleukin 17)
8.	Proteins (Proteins, Gene)
9.	Biomarkers (Surrogate Marker)
10.	Interleukin-22 (IL-22)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Drug Therapy (Chemotherapy)
4.	Transplantation
5.	Secondary Prevention