sprengerinin C

isolated from Ophiopogon japonicus; structure in first source

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

1.	Neoplasms (Cancer) 08/15/2013 - "In this study, we first found that sprengerinin C, a naturally derived compound strongly suppressed tumor angiogenesis in human umbilical vein endothelial cells. " 08/15/2013 - "Sprengerinin C also showed a significant anti-tumor effect in the nude mouse xenograft model of human hepatocellular carcinoma. " 08/15/2013 - "A mechanism study revealed that sprengerinin C blocked vascular endothelial growth factor receptor 2-dependent phosphoinositide 3-kinase/Akt/mTOR/matrix metalloproteinase and p38 MAPK/matrix metalloproteinase pathways, two major pathways for tumor angiogenesis. "
2.	Hepatocellular Carcinoma (Hepatoma) 08/15/2013 - "Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis." 08/15/2013 - "Sprengerinin C also showed a significant anti-tumor effect in the nude mouse xenograft model of human hepatocellular carcinoma. "
3.	Hypoxia (Hypoxemia) 08/15/2013 - "Moreover, sprengerinin C inhibited vascular endothelial growth factor release, a vital event for early angiogenesis response, from hypoxic HepG-2/BEL7402 cells by suppressing hypoxia-inducible factor-1α transcriptional activity. "

1.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
2.	p38 Mitogen-Activated Protein Kinases
3.	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
4.	Matrix Metalloproteinases (MMPs)
5.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)