daurinol

07/01/2015 - "Daurinol alone or in combination with radiation decreased lung cancer growth in xenograft mouse models. "
07/01/2015 - "Daurinol decreased cell viability and proliferation in human colon and lung cancer cells. "
08/22/2017 - "Consistent with these in vitro results, daurinol (10 mg/kg; Oral gavage) effectively inhibited breast and lung cancer metastasis in a mouse model. "
07/01/2015 - "Our data clearly confirm the antitumor and radiosensitizing activity of daurinol in human lung cancer cells through the inhibition of AURKA and AURKB."
07/01/2015 - "Furthermore, the expression of AURKA and AURKB was suppressed by daurinol in the presence or absence of radiation in colon and lung cancer cells. "

08/22/2017 - "Daurinol effectively suppressed migration and invasion of MDA-MB-231 and A549 cancer cells. "
11/01/2015 - "4-Aza-daurinol, a bioisosterism-based scaffold of daurinol, was designed and 17 analogues were synthesized and evaluated against five representative cancer cell lines. "
08/22/2017 - "Therefore, we have developed a neo-treatment strategy using daurinol to effectively treat cancer metastasis. "
08/22/2017 - "Daurinol blocked cancer cell migration and invasion in vitro and exhibited anti-metastatic activity in an experimental metastasis model of breast and lung cancer. "
08/01/2014 - "We also evaluated the anti-proliferative activity of daurinol in ovarian, small cell lung and testicular cancer cells, common target cancers treated with etoposide. "

08/01/2014 - "Daurinol, a lignan from the ethnopharmacological plant Haplophyllum dauricum, was recently reported to be a novel topoisomerase II inhibitor and an alternative to the clinical anticancer agent etoposide based on a colorectal cancer model. "

08/01/2014 - "We also evaluated the anti-proliferative activity of daurinol in ovarian, small cell lung and testicular cancer cells, common target cancers treated with etoposide. "

08/01/2014 - "Based on these data, we suggest that daurinol is a potential anticancer drug candidate for the treatment of human ovarian cancer with few side effects."
08/01/2014 - "Daurinol, a catalytic inhibitor of topoisomerase IIα, suppresses SNU-840 ovarian cancer cell proliferation through cell cycle arrest in S phase."
08/01/2014 - "Daurinol potently inhibited SNU-840 human ovarian cancer cell proliferation through cell cycle arrest in S phase, while etoposide induced G2/M phase arrest. "