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hirsutanol A

from fungus chondrostereum sp.; structure in first source

Networked: 6 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - hirsutanol A: 6

Experts

1.	Li, Hou-Jin: 4 articles (02/2013 - 07/2010)
2.	Yang, Fen: 4 articles (02/2013 - 07/2010)
3.	Zhu, Xiao-Feng: 4 articles (02/2013 - 07/2010)
4.	Deng, Rong: 3 articles (02/2013 - 07/2010)
5.	Feng, Gong-Kan: 3 articles (02/2013 - 07/2010)
6.	Li, Dan-Dan: 3 articles (02/2013 - 07/2010)
7.	Wu, Ke-Wei: 3 articles (02/2013 - 07/2010)
8.	Chen, Wen-Dan: 2 articles (02/2013 - 01/2012)
9.	Lan, Wen-Jian: 2 articles (02/2013 - 02/2011)
10.	Lan, Wenjian: 1 article (07/2021)

Related Diseases

1.	Neoplasms (Cancer) 02/08/2013 - "Our previous studies had demonstrated that hirsutanol A exhibited potent cytotoxic effect on many kinds of cancer cell lines. " 01/01/2012 - "Our previous studies had demonstrated that hirsutanol A exerted potent cytotoxic effect in many kinds of cancer cell lines. " 02/08/2013 - "These data suggested that hirsutanol A inhibited tumor growth through triggering ROS production and apoptosis." 02/08/2013 - "Also, hirsutanol A exhibited antitumor activity in human cancer cell SW620 xenograft model. " 02/08/2013 - "Finally, the in vivo anti-tumor effect of hirsutanol A was examined in human cancer cell SW620 xenograft model. "
2.	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 07/01/2021 - "In summary, the present study suggested that hirsutanol A inhibited Jurkat cell viability through induction of cell cycle arrest and p53-dependent initiation of apoptosis, thus hirsutanol may serve as a promising compound for the treatment of T-ALL."
3.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 07/01/2021 - "The aim of the present study was to evaluate the in vitro anticancer activity of hirsutanol A against T-acute lymphocytic leukemia Jurkat cells and investigate the mechanism of action. " 07/01/2021 - "Hirsutanol A inhibits T-acute lymphocytic leukemia Jurkat cell viability through cell cycle arrest and p53-dependent induction of apoptosis."
4.	Hepatocellular Carcinoma (Hepatoma) 07/01/2010 - "This study aimed to investigate cytotoxic effect of Hirsutanol A on hepatocellular carcinoma (HCC) cells and its mechanism. " 07/01/2010 - "A novel sesquiterpene Hirsutanol A induces autophagical cell death in human hepatocellular carcinoma cells by increasing reactive oxygen species."
5.	Breast Neoplasms (Breast Cancer) 01/01/2012 - "Here, the anticancer molecular mechanisms of hirsutanol A were investigated in breast cancer MCF-7 cells. " 02/08/2013 - "Hirsutanol A induced growth inhibition and apoptotic cell death of human colon cancer SW620 cells and human breast cancer MDA-MB-231cells were determined using MTT assay and flow cytometry assay, respectively. " 01/01/2012 - "Hirsutanol A induces apoptosis and autophagy via reactive oxygen species accumulation in breast cancer MCF-7 cells."

Related Drugs and Biologics

1.	Reactive Oxygen Species (Oxygen Radicals)
2.	Sesquiterpenes
3.	Cytochromes c (Cytochrome c)
4.	Matrix Metalloproteinase 9 (Gelatinase B)
5.	Cytokines
6.	Lipopolysaccharides
7.	pifithrin