Painful Neuropathy

A neuropathy characterized by progressive weakness, particularly of the legs with onset in infancy. Severe pains occurs in the hands and feet, aggravated by heat, hot weather or FEVER; MUSCULAR ATROPHY and sensory loss also occur. BIOPSY reveals tomaculous (sausage shaped) swellings affecting the nerve MYELIN SHEATHS. Autosomal recessive inheritance is suspected. OMIM: 256870

Also Known As:

Networked: 377 relevant articles (27 outcomes, 57 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Trigeminal Neuralgia (Tic Douloureux)
3.	Diabetic Neuropathies (Diabetic Neuropathy)
4.	Neuralgia (Stump Neuralgia)
5.	Postherpetic Neuralgia

Experts

1.	Lauria, Giuseppe: 11 articles (01/2020 - 09/2004)
2.	Waxman, Stephen G: 7 articles (01/2020 - 09/2004)
3.	Di Cesare Mannelli, Lorenzo: 7 articles (09/2018 - 06/2014)
4.	Ghelardini, Carla: 7 articles (09/2018 - 06/2014)
5.	Muthuraman, Arunachalam: 6 articles (10/2014 - 06/2008)
6.	Singh, Nirmal: 6 articles (02/2013 - 06/2008)
7.	Eschalier, Alain: 6 articles (02/2011 - 07/2002)
8.	Franchi, Silvia: 5 articles (11/2021 - 10/2008)
9.	Sacerdote, Paola: 5 articles (11/2021 - 10/2008)
10.	Faber, Catharina G: 5 articles (01/2020 - 11/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Painful Neuropathy:

1.	Analgesics (Analgesic Drugs)IBA 09/01/2015 - "These results suggest that axonal degeneration of the sciatic nerve is involved in BIPN and that some analgesic drugs and adjuvants are effective in the relief of painful neuropathy. " 02/01/2014 - "Further studies involving long-term applications are needed for a more decisive conclusion regarding the usefulness of GTX as an analgesic, especially in the treatment of painful neuropathy." 12/01/2011 - "  To investigate the analgesic efficacy of electroacupuncture (EA) in patients with chronic painful neuropathy. " 01/01/2020 - "Chronic alcohol use itself can produce a characteristic painful neuropathy, while the regular analgesic use of alcohol in the context of nociceptive sensitization and heightened affective pain sensitivity may promote negative reinforcement mechanisms that underlie AUD maintenance and progression. " 01/01/2016 - "Chemotherapy-induced painful neuropathy: pain-like behaviours in rodent models and their response to commonly used analgesics."
2.	Oxaliplatin (Eloxatin)FDA LinkGeneric 09/01/2018 - "While several attempts were made to prevent oxaliplatin-induced painful neuropathy, a growing number of evidences look to natural sources as an effective remedy to counterbalance the OXA-mediated side effects. " 05/05/2019 - "However, a large number of patients receiving oxaliplatin develop dose-limiting painful neuropathy. " 01/01/2018 - "Grade-2 patients received lower oxaliplatin cumulative dose than grade-1, which reveals effective dose adaptation and grade-2 patients were more likely to develop painful neuropathy. " 01/01/2018 - "Oxaliplatin treatment is associated with the development of a dose-limiting painful neuropathy impairing patient's quality of life. " 03/01/2016 - "The chemotherapeutic agent, oxaliplatin, produces a robust painful neuropathy that results in the loss of intraepidermal nerve fibers (IENFs). "
3.	NAD (NADH)IBA 06/01/2014 - "To examine the role of acupuncture in the treatment of diabetic painful neuropathy (DPN) using a single-blind, placebo-controlled RCT and to collect data that would be required in a future definitive study of the efficacy of acupuncture in DPN. " 07/01/2020 - "This study recruited 120 volunteers divided into four groups (30 per group): group 1 healthy volunteer (control); group 2 DM type 2 without neuropathy (DM group); group 3 DM type 2 with painful neuropathy (DPN group); group 4 DM type 2 without painful neuropathy (DN). " 10/24/2023 - "Diabetic painful neuropathy (DPN) is one of the most detrimental complications of diabetes. " 05/05/2023 - "A potential pathogenic variant was present in 18.1% (n = 142/784) of painful neuropathy patients vs. 15.2% (n = 52/341) of painless neuropathy patients (17.3% (n = 41/237) for painful-DPN patients, 14.9% (n = 46/309) for painless-DPN patients, 18.5% (n = 101/547) for painful-SFN patients, and 18.8% (n = 6/32) for painless-SFN patients). " 05/01/2022 - "Increased GV appears to be an independent risk factor for DPN and correlates with painful neuropathy. "
4.	Bortezomib (Velcade)FDA Link 12/01/2017 - "The aim of this study was to characterize a clinically relevant rat model of bortezomib-induced painful neuropathy, using established evoked measures and novel ethological techniques, to aid drug discovery. " 04/01/2010 - "Bortezomib-induced painful neuropathy in rats: a behavioral, neurophysiological and pathological study in rats." 01/01/2018 - "However, the mechanism by which administration of bortezomib leads to painful neuropathy remains unclear. " 01/01/2018 - "Painful neuropathy, as a severe side effect of chemotherapeutic bortezomib, is the most common reason for treatment discontinuation. " 12/01/2017 - "Characterization of a rat model of bortezomib-induced painful neuropathy."
5.	Gabapentin (Neurontin)FDA LinkGeneric 04/01/2004 - "Painful neuropathy alters the effect of gabapentin on sensory neuron excitability in rats." 01/01/2001 - "Nineteen patients with HIV-related painful neuropathy were administered Gabapentin. " 01/01/1999 - "Gabapentin monotherapy for the symptomatic treatment of painful neuropathy: a multicenter, double-blind, placebo-controlled trial in patients with diabetes mellitus." 12/31/2012 - "We motivate our discussion by analyzing data from a recent longitudinal study on the effect of gabapentin on pain among diabetic patients experiencing painful neuropathy." 08/01/2000 - "A patient with painful neuropathy developed ocular, facial, and masticatory weakness and fatigue after 3 months of gabapentin (GBP) treatment (400 mg/day). "
6.	Paclitaxel (Taxol)FDA LinkGeneric 10/18/2020 - "However, the molecular mechanisms underlying paclitaxel-induced painful neuropathy are largely unclarified. " 12/01/2018 - "Here, we investigated the potential of Gelsemium sempervirens (GS) to counteract paclitaxel-evoked painful neuropathy in rats. " 01/01/2018 - "Background One of the most common side effects of paclitaxel was dosage-dependently painful neuropathy. " 12/15/2017 - "Our findings suggest that paclitaxel-induced painful neuropathy is associated with increased presynaptic mGluR5 activity at the spinal cord level, which serves as upstream signaling for PKC-mediated tonic activation of NMDARs. " 01/01/2017 - "Paclitaxel-induced painful neuropathy is associated with changes in mitochondrial bioenergetics, glycolysis, and an energy deficit in dorsal root ganglia neurons."
7.	Opioid Analgesics (Opioids)IBA 11/25/2020 - "The current review presents the latest ideas on opioid-comprising hybrid drugs designed to treat painful neuropathy, with focus on their biological action, as well as limitations and challenges related to this therapeutic approach." 02/01/2005 - "This one describes effective opioid treatment for those diabetic patients failing nonopioid therapies for painful neuropathy." 08/16/2004 - "There is also a broad range of pharmaceuticals used in the treatment of painful neuropathy that range from tricyclic antidepressants, non-steroidal anti-inflammatory drugs, opioid analgesics, antiarrhythmics and even agents for topical use. " 09/01/2018 - "Using [F]-FDPN-PET in either sham rats (n = 17) or spared nerve injury rats (n = 17), we confirmed reduced opioid receptor availability in the insula, caudate-putamen, and motor cortex of nerve injured rats 3 months after surgery, indicating that painful neuropathy altered the endogenous opioid system. " 12/09/2004 - "Double blind, placebo controlled studies confirm the efficacy of the treatment of painful neuropathy, postherpetic neuralgia and trigeminal neuralgia with tricyclic antidepressants, ion channel blockers, opioids and lipoic acid. "
8.	Proteins (Proteins, Gene)FDA Link 01/01/2023 - "Immunoblots showed elevated Piezo1 protein in DRG proximal to peripheral nerve injury-induced painful neuropathy, while PSNs and SGCs from rats with neuropathic pain showed greater Yoda1-evoked elevation of [Ca2+]i and an increased frequency of cells responding to Yoda1, compared to controls. " 01/01/2022 - "By immunoblot and immunohistochemistry, we observed increased expression of both σ1R and σ1R-binding immunoglobulin protein (BiP) in the lumbar (L) dorsal root ganglia (DRG) ipsilateral to painful neuropathy induced by spared nerve injury (SNI). " 11/18/2011 - "Based on these data, we postulate that increased axonal mRNA transport results in accumulation of functional NaV1.8 protein in the injured nerve and the development of painful neuropathy symptoms. " 07/03/2007 - "IL-4 protein levels were 20-fold higher in patients with painless neuropathy (p < 0.0001) and 17-fold higher in patients with painful neuropathy (p < 0.0001) than in healthy control subjects. " 01/01/2021 - "Clinical evidence demonstrates that electro-acupuncture (EA) of the Zu sanli (ST36) and Shen shu (BL23) acupoints is effective in relieving diabetic painful neuropathy (DPN); however, the underlying molecular mechanism requires further investigation, including the protein molecules associated with EA's effects on DPN. "
9.	Tricyclic Antidepressive Agents (Tricyclic Antidepressants)IBA 08/16/2004 - "There is also a broad range of pharmaceuticals used in the treatment of painful neuropathy that range from tricyclic antidepressants, non-steroidal anti-inflammatory drugs, opioid analgesics, antiarrhythmics and even agents for topical use. " 07/01/1995 - "Treatment strategy of painful neuropathy with tricyclic antidepressant, anticonvulsant, anesthesia agents and topical capsaicin is discussed." 12/09/2004 - "Double blind, placebo controlled studies confirm the efficacy of the treatment of painful neuropathy, postherpetic neuralgia and trigeminal neuralgia with tricyclic antidepressants, ion channel blockers, opioids and lipoic acid. " 10/01/2007 - "(1) A large number of treatment options have shown generally moderate efficacy in the treatment of diabetic painful neuropathy.(2) Tricyclic antidepressants are the mainstay of therapy, with anticonvulsants, opioids and serotonin-noradrenaline reuptake inhibitors also having a place.(3) Head-to-head trials of current treatments are needed. " 01/01/2000 - "Pharmacologic treatment for painful neuropathy may include topical anesthetics, capsaicin cream, anticonvulsants, tricyclic antidepressants, mexiletine, and opioids. "
10.	Insulin (Novolin)FDA Link 05/01/2012 - "Insulin-triggered acute painful neuropathy is well-described although infrequent and still poorly-understood. " 08/01/2004 - "The mean (SD) fasting insulin concentrations were significantly (P = 0.01) higher in the patients [75.9 (44.4) mmol/l] than the controls [47.3 (37.9) mmol/l], and the mean was higher still in the painful neuropathy subgroup [92.2 (37.1) mmol/l] (P < 0.0001). " 07/01/1988 - "Assessment of small and large fiber function in long-term type 1 (insulin-dependent) diabetic patients with and without painful neuropathy." 12/01/2006 - "To describe the outcomes of 17 type-2 diabetics with painful neuropathy, treated between 1988 and 2005 with symptomatic therapy plus intensified insulin. " 08/01/2003 - "[Acute painful neuropathy at the initial period of effective insulin therapy]."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/2023 - "However, several studies suggest that PARPi attenuate chemotherapy-induced painful neuropathy. " 10/01/2021 - "This review highlights current literature and suggests novel approaches to CIPN based on proposed mechanisms of action that aim either to confer neuroprotection against chemotherapy-induced neurotoxicity or reverse the downstream effects of painful neuropathy." 01/01/2020 - "Chemotherapy-induced painful neuropathy (CIPN) is a severe adverse effect of many anti-neoplastic drugs that is difficult to manage. " 12/01/2017 - "The FOLFOX family of chemotherapy regimens are hampered by the development of a painful neuropathy. " 01/01/2017 - "The Therapeutic Potential of Monocyte/Macrophage Manipulation in the Treatment of Chemotherapy-Induced Painful Neuropathy."
2.	Therapeutics 04/01/2002 - "As patients live longer due to improved antiretroviral therapies, the impact of painful neuropathy on patients' lives may increase. " 11/01/2001 - "As patients live longer due to improved antiretroviral therapies, the impact of painful neuropathy on patients' lives may increase. " 04/01/2007 - "Those with painful neuropathy should only be prescribed therapies whose efficacy has been confirmed by independent randomized controlled trials." 11/18/2023 - "In conclusion, MLT/MT2 is a promising therapy for the treatment of pNEK2-dependent painful neuropathy resulting from PTX treatment. " 01/25/2018 - "Notably, the medical therapy proposed to eradicate HCV, can frequently exacerbate the painful neuropathy. "
3.	Electroacupuncture 01/01/2021 - "Proteomics Analysis of the Spinal Dorsal Horn in Diabetic Painful Neuropathy Rats With Electroacupuncture Treatment." 12/01/2011 - "  To investigate the analgesic efficacy of electroacupuncture (EA) in patients with chronic painful neuropathy. "
4.	Acupuncture Points (Acupuncture Point) 01/01/2021 - "Clinical evidence demonstrates that electro-acupuncture (EA) of the Zu sanli (ST36) and Shen shu (BL23) acupoints is effective in relieving diabetic painful neuropathy (DPN); however, the underlying molecular mechanism requires further investigation, including the protein molecules associated with EA's effects on DPN. "
5.	Drug Tapering 12/01/2017 - "However, its use is limited by painful neuropathy often resulting in dose reduction/cessation of first-line treatment due to lack of treatment. "