Tn Syndrome

10/08/1999 - "The idiopathic Tn-syndrome, formerly called 'permanent mixed-field polyagglutinability', is a rare hematological disorder characterized by the expression of the Tn-antigen on all blood cell lineages. "
12/01/1992 - "In order to examine expression of the Tn antigen on erythroid cells from a patient with Tn syndrome, we applied a selective two phase liquid culture system for human erythroid progenitors in peripheral blood. "
12/01/1992 - "Expression of the Tn antigen on erythroid cells from a patient with Tn syndrome."
02/01/1985 - "These results demonstrate that in the Tn syndrome, BFU-E, CFU-GM, and CFU-GEMM of the Tn+ clone express the Tn antigen at this early stage of differentiation."
02/01/1985 - "The Tn syndrome is an acquired clonal disorder characterized by the exposure of a normally hidden determinant, the Tn antigen, on the surface of human erythrocytes, platelets, granulocytes, and lymphocytes. "

08/01/1996 - "Constitutively hyposialylated human T-lymphocyte clones in the Tn-syndrome: binding characteristics of plant and animal lectins."
11/01/1983 - "It is suggested that these new lectin binding components are the sialoglycoproteins with deficient glycosylation resulting from the known deficiency of beta-3-galactosyltransferase in Tn syndrome."
11/01/1983 - "125I-Helix pomatia and 125I-wheat germ lectins were used as probes to visualise membrane glycoproteins of circulating blood cells from individuals with Tn syndrome. "
06/01/1993 - "In the present study, we took advantage of a Tn antigen expressing T-lymphocyte clone derived from a patient with the idiopathic form of the Tn syndrome and the Tn+ Jurkat cell line to characterize new reagents that should identify Tn antigens (monoclonal antibody 5F4 and a lectin newly isolated from Moluccella laevis seeds). "

10/01/2013 - "The Tn and STn antigens are also expressed in other human diseases and disorders, such as Tn syndrome and IgA nephropathy. "
01/01/1994 - "The cell-specific expression of glycan antigens exemplified by the deficiency of beta 1,3 galactosyltransferase in the Tn-syndrome."
06/01/1993 - "In the present study, we took advantage of a Tn antigen expressing T-lymphocyte clone derived from a patient with the idiopathic form of the Tn syndrome and the Tn+ Jurkat cell line to characterize new reagents that should identify Tn antigens (monoclonal antibody 5F4 and a lectin newly isolated from Moluccella laevis seeds). "

01/01/1990 - "Flow cytometric analysis employing monoclonal antibodies to the Tn antigen and glycophorin A was used to characterize the erythrocyte populations present in blood samples from individuals with Tn syndrome. "
01/01/1990 - "Flow cytometric analysis of erythrocyte populations in Tn syndrome blood using monoclonal antibodies to glycophorin A and the Tn antigen."
07/01/1992 - "To delineate the extent of O-galactosyltransferase deficiency within the lymphoid lineage, monoclonal antibody specific for the Thomsen-Friedenreich (TF) antigen (Gal beta 1----3GalNAc alpha 1-O-Ser/Thr) and its precursor the Tn antigen (GalNAc alpha 1-O-Ser/Thr) were applied to the flow cytometric analysis of peripheral blood lymphocytes from a patient with permanent mixed-field polyagglutinability (PMFP). "
06/01/1993 - "In the present study, we took advantage of a Tn antigen expressing T-lymphocyte clone derived from a patient with the idiopathic form of the Tn syndrome and the Tn+ Jurkat cell line to characterize new reagents that should identify Tn antigens (monoclonal antibody 5F4 and a lectin newly isolated from Moluccella laevis seeds). "

12/06/1979 - "We now report studies on the membrane GP composition and the T-transferase activity of platelets isolated from there Tn-syndrome patients whose red cell membranes contain GP abnormalities which are typical of those found in this rare clinical condition."

06/01/1993 - "In the present study, we took advantage of a Tn antigen expressing T-lymphocyte clone derived from a patient with the idiopathic form of the Tn syndrome and the Tn+ Jurkat cell line to characterize new reagents that should identify Tn antigens (monoclonal antibody 5F4 and a lectin newly isolated from Moluccella laevis seeds). "

01/01/2021 - "Altered expression of mucin-type O-glycans is known to be associated with several human disorders, including Tn syndrome and cancer; however, the physiological roles of mucin-type O-glycans in the mammalian brain remains largely unknown. "
03/01/1994 - "Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematologic disorder that resembles in several aspects the Tn-syndrome, in which bone marrow-derived cells are deficient in mucin-type beta 1,3 galactosyltransferase (beta 1,3Gal-T) due to the persistent repression of an intact allele. "
06/01/1993 - "The Tn antigen (GalNAc alpha 1-O-Ser/Thr) is a disease-related O-linked (mucin-type) carbohydrate neoantigen which is expressed in idiopathic Tn syndrome, AIDS, T-cell lymphoma and in many carcinomas. "
03/01/2011 - "Loss of T-synthase (uridine diphosphate galactose:N-acetylgalactosaminyl-α1-Ser/Thr β3galactosyltransferase), a key enzyme required for the formation of mucin-type core 1 O-glycans, is observed in several human diseases, including cancer, Tn syndrome and IgA nephropathy, but current methods to assay the enzyme use radioactive substrates and complicated isolation of the product. "
08/01/1994 - "The mucin-type carbohydrate Tn cryptantigen (GalNAc alpha 1-O-Ser/Thr, where GalNAc is N-acetyl-D-galactosamine) is expressed in many carcinomas, in haemopoietic disorders including the Tn syndrome, and on human immunodeficiency virus (HIV) coat glycoproteins, but is not expressed on normal, differentiated cells because of the expression of a Tn-processing galactosyltransferase. "

12/06/1979 - "Galactosyltransferase and membrane glycoprotein abnormality in human platelets from Tn-syndrome donors."
03/01/1994 - "Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hematologic disorder that resembles in several aspects the Tn-syndrome, in which bone marrow-derived cells are deficient in mucin-type beta 1,3 galactosyltransferase (beta 1,3Gal-T) due to the persistent repression of an intact allele. "
01/01/1994 - "The cell-specific expression of glycan antigens exemplified by the deficiency of beta 1,3 galactosyltransferase in the Tn-syndrome."
05/01/1993 - "A human hematopoietic disorder designated as Tn syndrome or permanent mixed-field polyagglutinability has been ascribed to a stem cell mutation leading to a specific deficiency of UDP-Gal:GalNAc alpha 1-O-Ser/Thr beta 1-3 galactosyltransferase (beta 3 Gal-T) activity in affected cells. "
08/01/1994 - "The mucin-type carbohydrate Tn cryptantigen (GalNAc alpha 1-O-Ser/Thr, where GalNAc is N-acetyl-D-galactosamine) is expressed in many carcinomas, in haemopoietic disorders including the Tn syndrome, and on human immunodeficiency virus (HIV) coat glycoproteins, but is not expressed on normal, differentiated cells because of the expression of a Tn-processing galactosyltransferase. "

11/01/1983 - "Evidence for carbohydrate-deficient forms of the major sialoglycoproteins of human platelets, granulocytes and T lymphocytes in individuals with Tn syndrome."
01/01/1995 - "Tn and sialyl-Tn carbohydrate structures, first identified in glycophorins of persons with the rare Tn syndrome, were found to be present on the surface of most cancer cells. "
06/01/1993 - "The Tn antigen (GalNAc alpha 1-O-Ser/Thr) is a disease-related O-linked (mucin-type) carbohydrate neoantigen which is expressed in idiopathic Tn syndrome, AIDS, T-cell lymphoma and in many carcinomas. "
01/01/1975 - "Spectrophotometric and gas-liquid chromatographic analyses on the carbohydrate moiety of tryptic erythrocyte glycopeptides from persons with Tn-syndrome reveal a selective lowering of the galactose and sialic acid content, the degree being dependent on the percentage of polyagglutinable cells. "
08/01/1994 - "The mucin-type carbohydrate Tn cryptantigen (GalNAc alpha 1-O-Ser/Thr, where GalNAc is N-acetyl-D-galactosamine) is expressed in many carcinomas, in haemopoietic disorders including the Tn syndrome, and on human immunodeficiency virus (HIV) coat glycoproteins, but is not expressed on normal, differentiated cells because of the expression of a Tn-processing galactosyltransferase. "

04/01/1994 - "These data suggest that incomplete galactosylation of N-linked glycans and its augmentation in RA does not extend to IgA1 and that the RA-associated galactosyltransferase deficiency may be restricted to cells producing gamma-chain."
01/01/2021 - "Altered expression of mucin-type O-glycans is known to be associated with several human disorders, including Tn syndrome and cancer; however, the physiological roles of mucin-type O-glycans in the mammalian brain remains largely unknown. "
01/01/1994 - "The cell-specific expression of glycan antigens exemplified by the deficiency of beta 1,3 galactosyltransferase in the Tn-syndrome."
03/01/2011 - "Loss of T-synthase (uridine diphosphate galactose:N-acetylgalactosaminyl-α1-Ser/Thr β3galactosyltransferase), a key enzyme required for the formation of mucin-type core 1 O-glycans, is observed in several human diseases, including cancer, Tn syndrome and IgA nephropathy, but current methods to assay the enzyme use radioactive substrates and complicated isolation of the product. "