Gastric Polyposis

A hereditary condition characterized by the presence of multiple gastric POLYPS and an increased susceptibility for developing stomach ADENOCARCINOMA in affected individuals. Autosomal dominant inheritance is suspected. OMIM: 175020

Also Known As:

Polyposis, Gastric

Networked: 47 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Adenocarcinoma
3.	Hemorrhage
4.	Aggressive Fibromatosis (Desmoid)
5.	Ulcer

Experts

1.	Burke, Carol A: 5 articles (01/2022 - 01/2021)
2.	Anderson, Joseph C: 3 articles (01/2022 - 01/2022)
3.	Boland, C Richard: 3 articles (01/2022 - 01/2022)
4.	Dominitz, Jason A: 3 articles (01/2022 - 01/2022)
5.	Durno, Carol: 3 articles (01/2022 - 01/2022)
6.	Giardiello, Francis M: 3 articles (01/2022 - 01/2022)
7.	Gross, Seth: 3 articles (01/2022 - 01/2022)
8.	Gupta, Samir: 3 articles (01/2022 - 01/2022)
9.	Idos, Gregory E: 3 articles (01/2022 - 01/2022)
10.	Jacobson, Brian C: 3 articles (01/2022 - 01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Gastric Polyposis:

1.	Celecoxib (Celebrex)FDA Link 10/01/2004 - "In a pilot clinical study, a subset of PJS patients (2/6) responded favorably to celecoxib with reduced gastric polyposis. "
2.	BariumIBA 10/01/1993 - "A 14-year-old female was found to have gastric polyposis by gastroscopy and barium meal study. "
3.	Proteins (Proteins, Gene)FDA Link 01/01/2022 - "Patients with SMAD4 pathogenic variants may have massive gastric polyposis, which can result in gastrointestinal bleeding and/or protein-losing gastropathy. " 01/01/2022 - "Patients with SMAD4 pathogenic variants may have massive gastric polyposis, which can result in gastrointestinal bleeding and/or protein-losing gastropathy. " 01/01/2022 - "Patients with SMAD4 pathogenic variants may have massive gastric polyposis, which can result in gastrointestinal bleeding and/or protein-losing gastropathy. " 09/01/1973 - "Trichobezoar, gastric polyposis, protein-losing gastroenteropathy and steatorrhoea." 01/01/2009 - "Albumin scintigram revealed protein losing gastropathy due to progressive gastric polyposis. "
4.	Omeprazole (Prilosec)FDA LinkGeneric 05/01/1993 - "Omeprazole and gastric polyposis in humans." 01/18/1993 - "Gastric polyposis: onset during long-term therapy with omeprazole." 11/02/1992 - "Gastric polyposis: onset during long-term therapy with omeprazole." 08/17/1992 - "Gastric polyposis: onset during long-term therapy with omeprazole." 01/01/2006 - "pylori eradication and omeprazole, the gastric polyposis, hypoalbuminemia and anemia regressed, and endoscopic polypectomy of gastric polyps were performed. "
5.	Proton Pump InhibitorsIBA 01/01/2020 - "Proton pump inhibitor-induced gastric polyposis: a silent recovery." 02/01/2009 - "[Gastric polyposis due to treatment with proton pump inhibitors]." 01/01/2006 - "pylori and proton pump inhibitor treatment might be considered in patients with gastric polyposis combined with Cronkhite-Canada syndrome."
6.	AntralIBA 01/01/1948 - "On a case of antral gastric polyposis." 09/02/2010 - "We describe the clinical scenario of a young male with history of non ulcer dyspepsia who had endoscopic evidence of gastric polyposis in antral area. " 09/30/2008 - "Gastroscopy showed massive gastric polyposis with a large antral polyp that had prolapsed through the pylorus causing gastric outlet obstruction. " 09/02/2010 - "A case of gastric polyposis in antral area of stomach following prolonged proton-pump therapy."
7.	GastrinsIBA 01/01/1986 - "[Role of gastrin in the pathogenesis of gastric polyposis]." 08/28/2008 - "She was treated with near-total gastrectomy and her anemia resolved Isolated diffuse hyperplasic gastric polyposis with normal gastrin level is a rare entity and can present with severe anemia."
8.	AlbuminsIBA 01/01/2009 - "Albumin scintigram revealed protein losing gastropathy due to progressive gastric polyposis. " 05/01/1998 - "Tc-99m albumin scintigraphy in protein-losing gastroenteropathy caused by gastric polyposis."
9.	Sirolimus (Rapamycin)FDA Link 01/01/2022 - "Potential impact of sirolimus on gastric polyposis burden in juvenile polyposis syndrome."
10.	Proton Pumps (Proton Pump)IBA 09/02/2010 - "A case of gastric polyposis in antral area of stomach following prolonged proton-pump therapy."

Therapies and Procedures

1.	Gastrectomy 02/01/2014 - "We discuss the use of a total gastrectomy with an Isoperistaltic jejunal interposition flap for the symptomatic management of gastric polyposis. " 09/30/2008 - "In this case report we present an unusual case of JPS that presented with massive gastric polyposis requiring a total gastrectomy. " 07/01/1979 - "Her elder brother received a subtotal gastrectomy because of gastric polyposis at 14 yr of age. " 09/17/1953 - "Diffuse gastric polyposis; treatment by total gastrectomy." 01/01/2022 - "When gastric cancers are discovered in cases of juvenile gastric polyposis, they are usually in an early stage, making them a good candidate for laparoscopic total gastrectomy."
2.	Restorative Proctocolectomy 04/07/2008 - "We present a case of a 23-year-old female patient with GS who presented with gastric polyposis and was successively treated with restorative proctocolectomy in combination with ileal pouch anal anastomosis (RPC/ IPAA), ileostomy, ileostomy closure operation, snare polypectomy during 8 mo. After operation, the patient took oral traditional Chinese medicine pills made of Fructus mume and Bombyx batryticatu for about 6 mo. The innutrition and anaemia of this patient were gradually improved. "
3.	Chinese Traditional Medicine (Traditional Chinese Medicine) 04/07/2008 - "We present a case of a 23-year-old female patient with GS who presented with gastric polyposis and was successively treated with restorative proctocolectomy in combination with ileal pouch anal anastomosis (RPC/ IPAA), ileostomy, ileostomy closure operation, snare polypectomy during 8 mo. After operation, the patient took oral traditional Chinese medicine pills made of Fructus mume and Bombyx batryticatu for about 6 mo. The innutrition and anaemia of this patient were gradually improved. "
4.	Ileostomy 04/07/2008 - "We present a case of a 23-year-old female patient with GS who presented with gastric polyposis and was successively treated with restorative proctocolectomy in combination with ileal pouch anal anastomosis (RPC/ IPAA), ileostomy, ileostomy closure operation, snare polypectomy during 8 mo. After operation, the patient took oral traditional Chinese medicine pills made of Fructus mume and Bombyx batryticatu for about 6 mo. The innutrition and anaemia of this patient were gradually improved. "
5.	Therapeutics 01/01/1990 - "[Microwave resonance therapy in the combined treatment of gastric polyposis]." 01/01/1964 - "[RESULTS OF SURGICAL THERAPY OF GASTRIC POLYPOSIS. " 01/18/1993 - "Gastric polyposis: onset during long-term therapy with omeprazole." 11/02/1992 - "Gastric polyposis: onset during long-term therapy with omeprazole." 08/17/1992 - "Gastric polyposis: onset during long-term therapy with omeprazole."