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Ulcer

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A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.

Also Known As:

Ulcers

Networked: 17275 relevant articles (1349 outcomes, 1888 trials/studies) for this Disease, Comments

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Disease Context: Research Results

Signs and Symptoms Pathological Conditions
- Pathologic Processes: 3289
  - Ulcer: 17275

Related Diseases

1.	Pain (Aches)
2.	Hemorrhage
3.	Ulcer
4.	Diabetic Foot
5.	Duodenal Ulcer (Curling's Ulcer)

Experts

1.	Konturek, S J: 15 articles (10/2011 - 05/2000)
2.	Konturek, P C: 15 articles (10/2011 - 05/2000)
3.	Brzozowski, T: 15 articles (10/2011 - 05/2000)
4.	Hawkey, C J: 14 articles (04/2007 - 06/2000)
5.	Armstrong, David G: 13 articles (07/2012 - 09/2002)
6.	Kirsner, Robert S: 11 articles (01/2012 - 08/2002)
7.	Lanas, Angel: 11 articles (10/2011 - 05/2002)
8.	Yoshikawa, Toshikazu: 10 articles (12/2012 - 10/2005)
9.	Watanabe, Toshio: 10 articles (09/2012 - 07/2002)
10.	Arakawa, Tetsuo: 10 articles (09/2012 - 07/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ulcer:

1.	Omeprazole (Esomeprazole)FDA LinkGeneric 01/01/1989 - "In conclusion, omeprazole 20 mg each morning was found to be safe and highly effective for treatment of gastric and prepyloric ulcer in Korean patients, producing a 98% healing rate. " 01/01/1989 - "The healing efficacy of omeprazole was assessed in 57 Korean patients with endoscopically-proven gastric (GU) and/or prepyloric (PPU) ulcers of at least 5 mm diameter. " 04/01/1999 - "Horses treated with omeprazole had significantly (P < 0.01) more improvement in ulcer scores at the end of the study compared with controls. " 11/01/2008 - "Both the extracts produced significant reduction in ulcer index (P < 0.05) in all the models and the results were comparable with that of omeprazole-treated group. " 06/01/2005 - "DG showed significant protection against CRU (68.37%), AL (88.87%), ASP (38.2%), PL (40.63%) and HST (63.15%) induced ulcer models, whereas standard drug omeprazole (OMZ) showed protection index of 83.86, 56.35, 70.31 and 84.21%, respectively in CRU, ASP, PL and HST models. " Order ALL the reference details at left...
2.	Ranitidine (Zantac)FDA LinkGeneric 02/13/1982 - "Ranitidine appears to be a safe and highly effective treatment of gastric ulceration, with about 90% of ulcers healed after eight weeks." 12/01/2005 - "The clinical effects of the combination of Jianweiyuyang granules and ranitidine capsules were better than those of western medicine, with improvement in symptoms and syndrome (P < 0.01 to 0.05), but there was not significant difference with the rate of ulcer healing and the Hp clearance among the combination of Jianweiyuyang granules and ranitidine capsules, Jianweiyuyang granules, and ranitidine capsules (P > 0.05). " 08/01/1985 - "Nocturnal gastric acid inhibition was significantly greater in patients who responded to ranitidine than in those whose ulcer did not heal. " 06/01/1982 - "Ulcer symptoms resolved or improved in a greater proportion of patients on ranitidine, and this was associated with a significantly lower antacid consumption. " 02/01/1990 - "Other ulcer related symptoms such as fullness etc. were more rapidly relieved with ranitidine. " Order ALL the reference details at left...
3.	Cimetidine (Biomet)FDA LinkGeneric 01/01/1978 - "In most studies Cimetidine is superior to placebo or equipotent to a high dose antacid regimen, the latter being accepted to be of beneficial effect on ulcer healing. " 07/01/1991 - "Cimetidine provided the best protection against stress-induced ulcers. " 01/01/1978 - "3. The marked sustained reduction of acid production most probably accounts for the protective effects of cimetidine against ulcer production in the rat stomach." 09/01/1978 - "Cimetidine, therefore, seems to be very effective in preventing stress induced ulcers in rat when instilled in the stomach before the stress." 01/01/1988 - "The decrease in the size of the ulcer was significantly greater in the first two weeks of cimetidine treatment than in the cimetidine-placebo group (P less than 0.05). " Order ALL the reference details at left...
4.	Sucralfate (Carafate)FDA LinkGeneric 12/01/2005 - "After the intervetion, there was a significant improvement in hand-hygiene practices (p<0.001) among healthcare providers and increased use of sucralfate (p=0.05) for stress ulcer prophylaxis. " 02/01/2001 - "The drug given orally in doses of 200 and 600 mg/kg twice daily for five days, showed significant protection against all the above experimental ulcer models and the results were comparable with those elicited by sucralfate (SF, 250 mg/kg, p.o., BD x 5 days). " 07/01/1994 - "The potential advantages of sucralfate lie in the better quality of ulcer healing associated with longer duration of remission." 06/09/1989 - "It is concluded that 1 g sucralfate twice daily is more effective than a placebo and is safe for the maintenance treatment of duodenal and pyloric ulcer disease." 01/01/1995 - "The mucosal-coating drug sucralfate has not been found effective in preventing NSAID ulcers. " Order ALL the reference details at left...
5.	Indomethacin (Indometacin)FDA LinkGeneric 11/01/1986 - "These compounds, as well as the 7-(2-chloropropionyl) derivative 2d, also exhibited antiinflammatory activity; in addition, 2c,d were highly effective in inhibiting indomethacin-induced ulcers in the rat." 02/01/1993 - "After a 2-week treatment with indomethacin, a histological study of the ulcers showed that the length of rupturing of the muscularis mucosa was significantly greater than that observed in the control group. " 11/01/2004 - "It also afforded significant protection against alcohol and indomethacin induced ulcer as well as stress induced ulceration. " 01/01/1989 - "Indometacin was effective in producing ulcers in the gastric antrum and small intestine, but not in the corpus of the stomach, when it was given to rats fasted for 24 h and fed for 1 h before drug administration. " 03/01/2002 - "3. The gastric mucosal protective effects of LP (1-20 mg/kg), OP (0.5-10 mg/kg) and PD (1-20 mg/kg), administered either orally or subcutaneously (s.c.) 30 min before the administration of AE or indomethacin, were dose dependent against both models of ulcer induction. " Order ALL the reference details at left...
6.	Ethanol (Ethyl Alcohol)IBA 08/01/1996 - "It is highly effective against ethanol-induced ulcers. " 09/01/2011 - "In the model of ethanol-induced ulcers, we observed a significant reduction in all the parameters analysed; the curative ratios obtained were 49.31±0.57, 74.31±0.91 and 79.86±0.59 for the groups treated with 50 and 100mg/kg of extract of M. " 03/21/2007 - "Ethanol extract of Toona ciliata showed significant reduction in gastric volume, free acidity, total acidity and ulcer index. " 01/01/2002 - "Further it showed significant cytoprotective activity against ethanol insult, that was evident from significant reduction in ulcer index. " 01/01/2012 - "This study aimed to investigate the gastroprotective mechanisms of Pithecellobium jiringa ethanol extract against ethanol-induced gastric mucosal ulcers in rats. " Order ALL the reference details at left...
7.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/01/1992 - "It is effective in preventing NSAID-induced ulcers, and does not interfere with the desired analgesic or anti-inflammatory effects of NSAIDs. " 01/01/1989 - "H2-receptor antagonists have proved effective in ulcer treatment, and their use as prophylaxis against the side effects of NSAIDs is being widely studied. " 01/01/1988 - "H2-receptor antagonists have proved effective in ulcer treatment, and their use as prophylaxis against the side-effects of NSAIDs is being widely studied. " 09/01/2008 - "To clarify this situation we have performed a systematic literature search to find randomized controlled trials comparing the efficacy of eradication in patients receiving NSAIDs to prevent ulcer development. " 09/15/2001 - "The author created a study (1989-1994) to determine the efficacy of one exposure (ulcer-healing drugs) in preventing the serious upper gastrointestinal toxicity associated with another exposure (nonsteroidal anti-inflammatory drugs (NSAIDs)). " Order ALL the reference details at left...
8.	Misoprostol (Cytotec)FDA LinkGeneric 09/06/2004 - "Maintenance of ulcer healing is significantly greater in those who receive ongoing PPI treatment compared with placebo, and adverse events and treatment withdrawals are fewer compared with their occurrence in persons treated with misoprostol. " 01/01/1992 - "Although therapy for patients with NSAID-induced ulcers or those at high risk of developing them is still a matter of debate, the current literature supports the use of misoprostol as the only drug effective for the prevention of both NSAID-induced gastric and duodenal ulceration. " 01/08/2001 - "That the Misoprostol Ulcer Complications Outcomes Safety Assessment (MUCOSA) trial found full-dose misoprostol to be more effective in ulcer prevention than it was in prevention of ulcer complications suggests that either many of the ulcer complications were related to H. " 03/01/2000 - "PPI have now been definitively shown to be more effective in the relief of symptoms and in the healing and prevention of ulcers/erosions than H2-antagonists and also better tolerated than misoprostol. " 05/01/1990 - "Studies to date indicate that the only appropriate therapy to prevent NSAID ulcers is misoprostol, and that this drug is also effective in healing such ulcers while NSAID treatment is continued. " Order ALL the reference details at left...
9.	AntacidsIBA 01/01/1988 - "Antacids, H(2) receptor antagonists, or both have proven beneficial in the prevention or reduction of gastrointestinal ulcers. " 01/01/1996 - "[Antacids for postoperative prevention of stress ulcer in infants: a dose finding study]." 09/01/1993 - "The advent of controlled endoscopic trials and the emergence of the H2-receptor blockers as a yardstick of ulcer therapy, however, facilitated reappraisal of the value of antacids in various conditions. " 09/01/1991 - "Even with the antisecretory compounds, the relationship between gastric acid and ulcer healing gives rise to perplexity: antacids prove effective at widely varying doses; pirenzipine and H2-blockers, which are clinically equieffective, differ considerably in antisecretory efficacy; H2-antagonist studies on early vs late postprandial dosing yield contradictory clinical results; morning and bedtime single administrations of H2-antagonists prove equiactive on ulcer healing, leading to a reappraisal of the alleged importance of nocturnal acidity. " 06/01/1990 - "Even with the antisecretory compounds, the relationship between gastric acid and ulcer healing gives rise to perplexity: antacids prove effective at widely varying doses; pirenzipine and H2-blockers, which are clinically equieffective, differ considerably in antisecretory efficacy; H2-antagonist studies on early vs late postprandial dosing, yield contradictory clinical results; morning and bedtime single administration of H2-antagonists prove equiactive on ulcer healing, leading to a appraisal of the alleged importance of nocturnal acidity. " Order ALL the reference details at left...
10.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/01/2012 - "Treatment with Terminalia belerica methanolic extract further provided significant antiulcer protection against aspirin induced ulcers but not in cold stress restraint model. " 07/16/1994 - "52% of the aspirin-treated group showed significant reduction in ulcer size compared with 26% of placebo recipients (p < 0.007). " 01/01/2008 - "There are many potential gastroprotective drugs available in Japan, and studies are needed to assess the relative effectiveness of various strategies including PPI use for the prevention of aspirin-related upper GI ulcer complications and whether any of these other agents also provide protection against small bowel or colonic damage. " 05/01/2010 - "There are a few studies of the association between genetic polymorphisms and the risks of acetylsalicylic acid (aspirin)-induced ulcer or its complications. " 01/01/2009 - "We also review several pathogenic mechanisms that have been advanced by animal studies to explain the finding that a COX-2 selective inhibitor plus low-dose aspirin leads to an ulcer rate near that of a dual COX-1/COX-2 inhibitor alone." Order ALL the reference details at left...

Therapies and Procedures

1.	Amputation 03/01/2011 - "The study group showed a significant reduction in the median time needed to heal ulcers, reduction of the number of admissions and amputation frequency." 01/01/2005 - "Pooled data from five trials on diabetic ulcers (118 patients) suggested a significant reduction in the risk of major amputation with HBOT (RR: 0.31; c.i. 0.13 to 0.71) with a NNT of 4 (c.i. 3 to 11). " 07/01/2011 - "Of the 937 ambulatory diabetic patients identified during this time period, 808 who presented with superficial ulcers or distal forefoot disease and who did not go on to PF/M or higher amputation were eliminated. " 01/01/2012 - "Yet, based on the only two sufficiently powered studies reporting the effect of patient education on primary end points, we conclude that there is insufficient robust evidence that limited patient education alone is effective in achieving clinically relevant reductions in ulcer and amputation incidence." 01/01/2010 - "Based on these two studies, we conclude that there is insufficient robust evidence that limited patient education alone is effective in achieving clinically relevant reductions in ulcer and amputation incidence.Future" Order ALL the reference details at left...
2.	Debridement 12/01/2003 - "The latter two procedures may be beneficial in the treatment of nonhealing ulceration in horses, but the results of this study suggest that these procedures should only be performed following failure of the ulcer to heal after epithelial debridement." 10/01/2012 - "These two cases suggest that wide excision, thorough debridement and coverage with vascularised tissue are effective in treating radiation ulcers and emphasise that all radiation sources and their management should be strictly controlled." 02/01/2009 - "We reduced the dose of immunosuppressive drug and performed debridement of the ulcer, which responded well to treatment. " 05/01/2006 - "On minimal improvement in the epithelial defect in 1 week, surgical debridement of the ulcer base was performed. " 07/01/2011 - "Subjects with DFUs underwent sharp debridement of the study ulcer and were prescribed an off-loading device. " Order ALL the reference details at left...
3.	Transplants (Transplant) 04/01/2000 - "Postoperative angiography showed satisfactory graft patency and distal run-off, and the ulcer improved. " 01/01/2011 - "autologous skin cell grafts are feasible, well tolerated, and apparently effective in the treatment of diabetic ulcers of the lower limbs in advanced age. " 06/01/2002 - "Pinch grafts are very useful for arterial ulcers. " 01/01/2011 - "Live skin equivalent and fibroblasts in gel were used in complex treatment of venous trophic ulcers to evaluate efficacy of cell transplants. " 03/01/2007 - "To evaluate the efficacy of using a porcine small intestinal submucosa (SIS) graft for the surgical repair of deep melting ulcers in dogs and cats. " Order ALL the reference details at left...
4.	Vagotomy 01/01/1988 - "Thus basal and stimulated acid output is normal in most ulcer patients, and this is also so for gastric and duodenal pH. Gastric acid secretion does not separate patients with rapid recurrence after medical treatment from those with a long period of remission, and acid secretion is usually not higher in patients with recurrence after vagotomy than in patients without relapse. " 12/01/1990 - "It was established that intraoperative pH measurement, carried out by an improved procedure, provided for objective control over complete and adequate vagotomy, made it possible to predict the risk of ulcer recurrence in the postoperative period and, in accordance with that, to choose the methods for its prevention." 01/01/2008 - "Vagotomy at the patients with ulcers after primary resections demonstrates good results. " 01/01/2000 - "This method of vagotomy was used in 46 patients with ulcer disease of the duodenum and gave good results. " 01/01/1993 - "With the availability of effective medication for control of gastric acidity, the need for selective vagotomy or elective operative procedure for ulcers is fast disappearing." Order ALL the reference details at left...
5.	Lasers (Laser) 11/01/2005 - "Laser energy density of 5 J/cm2 was the most effective for maximally complete healing of radiation ulcers." 01/01/2001 - "The efficacy of local use of a new drug miliacil in combination with laser radiation was studied in 44 patients with trophic ulcer of different origin. " 06/01/2011 - "Recently, conventional therapy-resistant chronic ulcers have been treated with low energy lasers or light-emitting diodes in the visible and near IR region, but only a few placebo-controlled double-blind studies have been performed to support the efficacy of this approach. " 01/01/1995 - "4 cases of larynx contact ulcer cured with the use of laser resection of vocal process of arytenoid cartilage were presented. " 01/01/1986 - "It is shown that the efficacy of laser radiation treatment is dependent on the ulcer localization." Order ALL the reference details at left...

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