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golgicide A

inhibits the cis-golgi ArfGEF GBF1; structure in first source

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - golgicide A: 6
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - golgicide A: 6

Experts

1.	Guo, Kangkang: 1 article (01/2022)
2.	Jin, Mingxing: 1 article (01/2022)
3.	Song, Mengzhao: 1 article (01/2022)
4.	Wang, Tao: 1 article (01/2022)
5.	Yi, Yanyan: 1 article (01/2022)
6.	Zhang, Liang: 1 article (01/2022)
7.	Zhang, Yanming: 1 article (01/2022)
8.	Gerold, Gisa: 1 article (12/2019)
9.	Goffinet, Christine: 1 article (12/2019)
10.	Kampmann, Martin: 1 article (12/2019)

Related Diseases

1.	Infections 12/01/2019 - "An inhibitor of GBF1, Golgicide A, confirmed the role of the cellular factor in UUKV infection. " 01/01/2022 - "In this study, we constructed a series of plasmids expressing GBF1 truncation mutants to investigate their behavior during CSFV infection and found that GBF1 truncation mutants containing the Sec7 domain could rescue CSFV replication in BFA- and GCA (golgicide A)-treated swine umbilical vein endothelial cells (SUVECs), demonstrating that the effect of GBF1 on CSFV infection depended on the activity of guanine nucleotide exchange factor (GEF). " 11/25/2017 - "Moreover, CHIKV infection is abolished by the presence of ARF1 inhibitor brefeldin A or GBF1 inhibitor golgicide A. " 11/01/2014 - "UPR was triggered by knockdown of Golgi-specific brefeldin A-resistant guanine nucleotide exchange factor 1 (GBF-1) or the GBF-1 inhibitor golgicide A (GCA) and stimulated HAdV infection. "
2.	Neoplasms (Cancer) 01/01/2017 - "Using several human cancer cell lines, we studied the effects of AMF-26, BFA and golgicide A on cell homeostasis including Golgi structure, endoplasmic reticulum (ER) stress markers, secretion and viability, and found overall a significant correlation between these parameters. " 01/01/2018 - "We also identify a new exon 2b in GOLGA2 transcript and the exon exclusion contributes to PTEN knockdown-induced tumorigenesis by promoting dramatic Golgi extension and secretion, and PTEN depletion significantly sensitizes cancer cells to secretion inhibitors brefeldin A and golgicide A. "
3.	Carcinogenesis 01/01/2018 - "We also identify a new exon 2b in GOLGA2 transcript and the exon exclusion contributes to PTEN knockdown-induced tumorigenesis by promoting dramatic Golgi extension and secretion, and PTEN depletion significantly sensitizes cancer cells to secretion inhibitors brefeldin A and golgicide A. "

Related Drugs and Biologics

1.	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)
2.	Brefeldin A
3.	N- (pyridine- 3- ylmethyl)- 5- (7- hydroxy- 2,6,8- trimethyl- 1,2,4a,5,6,7,8,8a- octahydronaphthalene- 1- yl)- 2- methylpenta- 2,4- dienamide