rat Cyp3a23-3a1 protein

microsomal cytochrome P-450 monooxygenase found in liver; oxidizes a variety of structurally unrelated compounds including steroids, fatty acids, and xenobiotics; inducible by drugs such as pregnenolone 16-alpha-carbonitrile (PNCN), RefSeq NM_013105

Also Known As:

Cyp3a23-3a1 protein, rat; CYP3A23; CYP3A23 protein, rat; CYPIIIA1 protein, rat; Cyp3a1 protein, rat; P450-PCN1 (rat); cytochrome P-450 CYP3A1 (rat); cytochrome P450 3A1, rat; cytochrome P450 CYP3A23; cytochrome P450 CYP3A23 (rat); cytochrome P450 IIIA (steroid inducible); cytochrome P450, family 3, subfamily a, polypeptide 1, rat

Networked: 9 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chung, Hye Chin: 2 articles (06/2003 - 12/2002)
2.	Kim, Eun Jung: 2 articles (06/2003 - 12/2002)
3.	Kim, Sang Geon: 2 articles (06/2003 - 12/2002)
4.	Kim, So Hee: 2 articles (06/2003 - 12/2002)
5.	Lee, Myung Gull: 2 articles (06/2003 - 12/2002)
6.	Akopian, Armen: 1 article (10/2012)
7.	Hargreaves, Kenneth M: 1 article (10/2012)
8.	Henry, Michael A: 1 article (10/2012)
9.	Patil, Mayur: 1 article (10/2012)
10.	Roman, Linda: 1 article (10/2012)

Related Diseases

1.	Acute Kidney Injury (Acute Renal Failure) 01/01/2004 - "Effects of acute renal failure induced by uranyl nitrate on the pharmacokinetics of 2-(allylthio) pyrazine, a chemoprotective agent, in rats: the role of CYP3A23 induction." 12/01/2002 - "In rats with acute renal failure induced by uranyl nitrate, the hepatic microsomal cytochrome P450 (CYP) 2E1 and CYP3A23 increased 2-4- and 4-times, respectively, CYP2C11 decreased to 80% of control, but the levels of CYP1A2 and CYP2B1/2 were not changed. " 06/01/2003 - "The purpose of this study is to report the changes of CYP2E1, CYP1A2, CYP2B1/2, CYP2C11, CYP3A23, and CYP3A2 expression and pharmacokinetics and tissue distribution of chlorzoxazone (CZX) and 6-hydroxychlorzoxazone (OH-CZX) in rats with acute renal failure induced by uranyl nitrate (U-ARF), and the role of CYP3A23 and CYP3A2 in the formation of OH-CZX in rats with U-ARF. "
2.	Malnutrition (Nutritional Deficiencies) 12/01/2008 - "Effects of intrauterine undernutrition on the expression of CYP3A23/3A1, PXR, CAR and HNF4alpha in neonate rats." 12/01/2008 - "In conclusion, these findings suggest that undernutrition may influence the mRNA expression of CAR and protein expression of both CYP3A23/3A1 and CAR in neonatal rats. " 12/01/2008 - "The present study investigated the effects of undernutrition in utero on hepatic mRNA and protein expression of the enzyme CYP3A23/3A1 and nuclear receptors including pregnane X receptor (PXR; NR1I2), constitutive androstane receptor (CAR; NR1I3) and nuclear factor-4alpha (HNF4alpha; HNF4A) in neonatal rats. "
3.	Hepatocellular Carcinoma (Hepatoma) 07/01/2012 - "The suitability of rat hepatoma cell line H4IIE for evaluating the potentials of compounds to induce CYP3A23 expression." 07/01/2003 - "2. Host cell effects were investigated by trans-species transient transfection of reporter genes containing either the rat CYP3A23 or human CYP3A4 proximal promoters into human HepG2 and rat FaO and H4IIEC3 hepatoma cells. "
4.	Body Weight (Weight, Body) 02/15/2005 - "Quantitative real time RT-PCR assays of rat hepatic RNA samples from animals treated at the 150 mg/kg body weight/day dose revealed significant mRNA overexpression of the following genes compared to control: CYP1A2 (1.62-fold), CYP2B1 (10.8-fold), CYP3A1/CYP3A23 (2.78-fold), and CYP3A2 (1.84-fold). " 01/01/2005 - "quinquefolius extracts did not affect body weight gain, absolute or relative liver weight, hepatic CYP2B1, CYP3A23, or CYP1A2 mRNA expression, or microsomal CYP2B-mediated 7-benzyloxyresorufin O-dealkylation (BROD) or CYP1A-mediated 7-ethoxyresorufin O-dealkylation (EROD) activity. "
5.	Inflammation (Inflammations) 10/01/2012 - "Moreover, complete Freund's adjuvant-induced inflammation of vibrissal pad selectively increased expression of CYP3A23/3A1 and CYP2J4 transcripts in TG. "

Related Drugs and Biologics

1.	Cytochrome P-450 CYP1A2 (CYP1A2)
2.	Cytochrome P-450 CYP2B1 (PROD)
3.	Uranyl Nitrate
4.	Messenger RNA (mRNA)
5.	Cytochrome P-450 CYP2E1 (CYP2E1)
6.	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)
7.	Proteins (Proteins, Gene)
8.	Enzymes
9.	Chlorzoxazone
10.	Constitutive Androstane Receptor