leukocyte-associated immunoglobulin-like receptor 1

an inhibitory receptor expressed on mononuclear leukocytes; MW 32 kDa; amino acid sequence given in first source; GenBank AF013249

Also Known As:

LAIR-1 receptor; LAIR-1 receptors; receptor, LAIR1

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        leukocyte-associated immunoglobulin-like receptor 1: 7

Experts

1.	Meyaard, Linde: 2 articles (01/2021 - 01/2020)
2.	Boon, Louis: 1 article (01/2021)
3.	Copeland, Ronald: 1 article (01/2021)
4.	Flies, Dallas: 1 article (01/2021)
5.	Langermann, Sol: 1 article (01/2021)
6.	Meeldijk, Jan: 1 article (01/2021)
7.	Mommers-Elshof, Eline T A M: 1 article (01/2021)
8.	Ramos, M Inês Pascoal: 1 article (01/2021)
9.	Singh, Akashdip: 1 article (01/2021)
10.	Vijver, Saskia V: 1 article (01/2021)

Related Diseases

1.	Squamous Cell Carcinoma of Head and Neck 01/01/2019 - "This study aims to investigate the characteristic role of inhibitory receptor leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) in oral squamous cell carcinoma (OSCC). "
2.	Neoplasms (Cancer) 01/01/2021 - "Collagen Fragments Produced in Cancer Mediate T Cell Suppression Through Leukocyte-Associated Immunoglobulin-Like Receptor 1." 03/01/2023 - "We discovered that MARCO expression was lowest in pancreatic adenocarcinoma (PAAD) and rectum adenocarcinoma (READ) stage 1, BLCA stage 2, LUSC and stomach adenocarcinoma (STAD) stage 3, and liver hepatocellular carcinoma (LIHC) stage 4. Subsequently, we analyzed the correlation between MARCO and 47 immune checkpoints and observed that MARCO was positively connected with CD80, CD86, and leukocyte-associated immunoglobulin-like receptor 1(LAIR1) in most cancers. "
3.	Inflammation (Inflammations) 01/01/2020 - "Leukocyte Associated Immunoglobulin Like Receptor 1 Regulation and Function on Monocytes and Dendritic Cells During Inflammation." 12/01/2022 - "Indeed, we previously showed that the inhibitory collagen receptor leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) regulates neutrophilic airway inflammation and inhibits neutrophil extracellular trap formation. "
4.	Ovarian Neoplasms (Ovarian Cancer) 05/01/2023 - "We previously presented the first evidence for the expression of leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1), a member of the immunosuppressive receptor family, in ovarian cancer cells. "
5.	Hepatocellular Carcinoma (Hepatoma) 03/01/2023 - "We discovered that MARCO expression was lowest in pancreatic adenocarcinoma (PAAD) and rectum adenocarcinoma (READ) stage 1, BLCA stage 2, LUSC and stomach adenocarcinoma (STAD) stage 3, and liver hepatocellular carcinoma (LIHC) stage 4. Subsequently, we analyzed the correlation between MARCO and 47 immune checkpoints and observed that MARCO was positively connected with CD80, CD86, and leukocyte-associated immunoglobulin-like receptor 1(LAIR1) in most cancers. "

Related Drugs and Biologics

1.	Collagen Receptors
2.	Lectins
3.	N-Acetylneuraminic Acid (Sialic Acid)
4.	Proteins (Proteins, Gene)
5.	Phosphatidylinositols (Phosphatidylinositol)
6.	Immunoglobulins (Immunoglobulin)
7.	Collagen