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S 8921
inhibits bile acid transport; structure given in first source
Also Known As:
S-8921; S8921 cpd; methyl-1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate
Networked:
2
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Polycyclic Aromatic Hydrocarbons: 2020
Naphthalenes: 18
Naphthols: 64
S 8921: 2
Polycyclic Compounds: 6
Polycyclic Aromatic Hydrocarbons: 2020
Naphthalenes: 18
Naphthols: 64
S 8921: 2
Experts
1.
Booker, M L
: 1 article (03/2001)
Related Diseases
1.
Hypercholesterolemia
08/01/1998 - "
We suggest that an IBAT inhibitor such as S-8921 could be useful in the treatment of hypercholesterolemia.
"
08/01/1998 - "
In cholesterol-fed New Zealand White rabbits, S-8921 treatment (0.003% to 0.1% in the diet) for 10 weeks dose-dependently inhibited the development of hypercholesterolemia.
"
2.
Atherosclerosis
08/01/1998 - "
Inhibition of ileal Na+/bile acid cotransporter by S-8921 reduces serum cholesterol and prevents atherosclerosis in rabbits.
"
08/01/1998 - "
These results indicate that IBAT inhibition by S-8921 affects serum cholesterol, liver enzymes, low density lipoprotein receptor activity, and atherosclerosis in the same manner as bile acid sequestrants.
"
3.
Hyperlipidemias (Hyperlipidemia)
03/01/2001 - "
S-8921 is a sodium/bile acid transport inhibitor under development by Shionogi for the potential treatment of hyperlipidemia.
"
Related Drugs and Biologics
1.
Bile Acids and Salts (Bile Acids)
2.
Sodium
3.
LDL Receptors (LDL Receptor)
4.
Enzymes
5.
Cholesterol
6.
sodium-bile acid cotransporter