HLA-B46 antigen

11/01/2019 - "Both the Nail Psoriasis Severity Index and grade of sacroiliitis were significantly higher in the HLA-B46-positive group (Mann-Whitney U test; p = .0003 and p = .028, respectively).Conclusion: HLA-B46 is considered a risk factor for severe sacroiliitis in Japanese patients with PsA."
09/01/2021 - "Our findings suggest that the HLA-B46 and HLA-Cw1 combination contributes to the development of psoriasis in this Asian population."
11/01/2010 - "No association was seen in Thai HLA-Cw1 haplotypes lacking HLA-B46, nor was HLA-Cw1 associated with psoriasis in a large Caucasian sample. "
11/01/2010 - "Earlier studies have shown that psoriasis in Japan and Thailand is associated with two different major histocompatibility complex (MHC) haplotypes - those bearing HLA-Cw6 and those bearing HLA-Cw1 and HLA-B46. "

02/15/2003 - "These results provide a scientific basis for the development of p53-directed specific immunotherapy for HLA-B46(+) cancer patients."
12/01/2003 - "The objective of this study was to identify novel genes and peptides capable of inducing tumor-reactive cytotoxic T lymphocytes (CTLs) in cancer patients with an HLA-B46 allele, which is preferentially expressed in Asians. "
02/15/2003 - "These peptide-induced CTLs did not react to either HLA-B46(+) tumor cells without the p53 mutation or to HLA-B46(+) phytohemagglutinin-blastoid cells. "

03/01/1994 - "HLA alleles of 106 patients with Graves' disease were determined, and the frequency of HLA-B46 was found to be significantly increased. "
09/01/1989 - "HLA Bw46 and DR9 associations in Graves' disease of Chinese patients are age- and sex-related."
10/01/1987 - "Japanese Graves' disease: association with HLA-Bw46."
01/01/1994 - "HLA-B46, DR9 and DQB1*0303 were associated with Graves' disease in males only; these associations were weaker in males with thyrotoxic periodic paralysis. "
07/01/1993 - "We report two cases of Down syndrome with Graves disease both with significantly elevated titres of thyrotropin receptor antibody and the presence of the HLA Bw46. "

03/01/1986 - "It is suggested that ocular myasthenia gravis is determined by a pathological mechanism for which susceptibility is determined by HLA BW46. "
03/01/1986 - "HLA BW46 had a significantly increased prevalence in patients with juvenile onset ocular myasthenia gravis. "
05/01/1984 - "There was a significantly increased prevalence of HLA BW46 in the patients compared with controls (67% vs 26.4%, p less than 0.005) indicating that BW46 confers a relative risk of 5.6 for juvenile onset myasthenia gravis in Chinese children. "
05/01/1984 - "Strong association of HLA BW46 with juvenile onset myasthenia gravis in Hong Kong Chinese."

11/01/2019 - "Ordered logistic regression analysis revealed that the presence of HLA-B46 was an independent risk factor for severe sacroiliitis in Japanese PsA patients (odds ratio 3.2; 95% confidence interval 1.16-9.81). "
11/01/2019 - "Both the Nail Psoriasis Severity Index and grade of sacroiliitis were significantly higher in the HLA-B46-positive group (Mann-Whitney U test; p = .0003 and p = .028, respectively).Conclusion: HLA-B46 is considered a risk factor for severe sacroiliitis in Japanese patients with PsA."
11/01/2019 - "HLA-B46 is associated with severe sacroiliitis in Japanese patients with psoriatic arthritis."