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trimetrexate glucuronate (NeuTrexin)
an orphan drug and AIDS drug; used for treatment of Pneumocytis carinii pneumonia in patients with AIDS
Also Known As:
NeuTrexin
; NSC 352122; NSC-352122; trimetrexate glucuronic acid combination
Networked:
11
relevant articles (
0
outcomes,
2
trials/studies)
Drug Context: Research Results
Pharmaceutical Preparations
Drug Combinations: 5337
trimetrexate glucuronate: 11
Organic Chemicals: 133
Carboxylic Acids: 973
Hydroxy Acids: 94
Sugar Acids: 4
Uronic Acids: 152
Glucuronates: 3
trimetrexate glucuronate: 11
Acyclic Acids
Sugar Acids: 4
Uronic Acids: 152
Glucuronates: 3
trimetrexate glucuronate: 11
Aldehydic Acids
Uronic Acids: 152
Glucuronates: 3
trimetrexate glucuronate: 11
Carbohydrates: 22023
Sugar Acids: 4
Uronic Acids: 152
Glucuronates: 3
trimetrexate glucuronate: 11
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Quinazolines: 402
Trimetrexate: 180
trimetrexate glucuronate: 11
Experts
1.
Amado, R G
: 1 article (04/2002)
2.
Hecht, J R
: 1 article (04/2002)
3.
Lin, L S
: 1 article (04/2002)
4.
Rosen, L S
: 1 article (04/2002)
5.
Rosen, P J
: 1 article (04/2002)
Related Diseases
1.
Neoplasms (Cancer)
10/01/1996 - "
When trimetrexate glucuronate and leucovorin rescue were administered, his tumor burden decreased significantly, suggesting that trimetrexate glucuronate may have some activity against KS.
"
01/01/1987 - "
Trimetrexate glucuronate (TMTX) is a methotrexate (MTX) analog that is active against transport-deficient MTX-resistant tumor cells.
"
06/01/1987 - "
The disposition of the methotrexate analogue trimetrexate (TMTX, NSC 352122; 2,4-diammino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]qui nazoline) was determined in a Phase I study in 16 patients with refractory or relapsing cancer.
"
09/01/1988 - "
Trimetrexate (TMQ; NSC 352122) is a potent inhibitor of dihydrofolate reductase with good activity against murine i.p.-implanted B16 melanoma and colon 26 tumors.
"
10/01/1996 - "
Trimetrexate glucuronate, a dihydrofolate reductase inhibitor related to methotrexate, was developed by Parke-Davis as an alternative antineoplastic agent for tumors, especially sarcomas, that had developed resistance to methotrexate.
"
2.
Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
04/01/1988 - "
Trimetrexate glucuronate was evaluated in 70 nonsmall cell lung cancer patients with incurable disease and/or demonstrated progression following surgery/radiotherapy and no prior cytotoxic chemotherapy.
"
04/01/1988 - "
To determine the maximum tolerated dose (MTD) of trimetrexate glucuronate in combination with cyclophosphamide in patients with metastatic or inoperable nonsmall cell lung cancer (NSCLC), trimetrexate in dosages ranging from 3 to 13.5 mg/m2/day was administered intravenously (IV) to 27 patients for 5 days in combination with cyclophosphamide, 600 mg/m2, on day 1. Patients received between one and six courses of treatment at 3 week intervals, 69 treatment courses in all.
"
04/01/1988 - "
Trimetrexate glucuronate in combination therapy with cisplatin or etoposide was evaluated in non-small cell lung cancer patients in a pilot, dose escalation study.
"
3.
Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia)
10/29/1993 - "
Pharmacokinetics of trimetrexate glucuronate in infants with AIDS and Pneumocystis carinii pneumonia.
"
10/01/1996 - "
This is a report on a patient with AIDS who developed Pneumocystis carinii pneumonia, which was treated with trimethoprim sulfamethoxazole (Bactrim) with poor response, then with pentamidine with poor response, and finally with trimetrexate glucuronate (Neutrexin) and leucovorin rescue, with good response.
"
4.
Acquired Immunodeficiency Syndrome (AIDS)
10/29/1993 - "
Pharmacokinetics of trimetrexate glucuronate in infants with AIDS and Pneumocystis carinii pneumonia.
"
10/01/1996 - "
This is a report on a patient with AIDS who developed Pneumocystis carinii pneumonia, which was treated with trimethoprim sulfamethoxazole (Bactrim) with poor response, then with pentamidine with poor response, and finally with trimetrexate glucuronate (Neutrexin) and leucovorin rescue, with good response.
"
5.
Kaposi Sarcoma (Kaposi's Sarcoma)
10/01/1996 - "
Trimetrexate glucuronate associated with anti-Kaposi sarcoma effect.
"
Related Drugs and Biologics
1.
Trimetrexate (JB11)
2.
Methotrexate (Mexate)
3.
Etoposide (VP 16)
4.
Cisplatin (Platino)
5.
trimetrexate glucuronate (NeuTrexin)
6.
Folic Acid Antagonists
7.
Foscarnet
8.
Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)
9.
Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)
10.
Pentamidine (NebuPent)
Related Therapies and Procedures
1.
Therapeutics
2.
Radiotherapy
3.
Drug Therapy (Chemotherapy)