HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

hydroxygenkwanin

isolated from leaves of Daphne genkwa

Networked: 10 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        hydroxygenkwanin: 10
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        hydroxygenkwanin: 10

Experts

1.	Chen, Chi-Yuan: 4 articles (09/2021 - 12/2019)
2.	Leu, Yann-Lii: 4 articles (09/2021 - 12/2019)
3.	Wang, Tong-Hong: 4 articles (09/2021 - 12/2019)
4.	Chen, Chin-Chuan: 3 articles (09/2021 - 12/2019)
5.	Chou, Li-Fang: 2 articles (09/2021 - 12/2019)
6.	Chuang, Wen-Yu: 2 articles (09/2021 - 01/2020)
7.	Ueng, Shir-Hwa: 2 articles (09/2021 - 01/2020)
8.	Hsu, Yi-Chiung: 2 articles (02/2020 - 01/2019)
9.	Cheng, Shu-Fang: 1 article (09/2021)
10.	Liu, Kuang-Ting: 1 article (09/2021)

Related Diseases

1.	Neoplasms (Cancer) 10/23/2022 - "Hydroxygenkwanin Improves the Efficacy of Cytotoxic Drugs in ABCG2-Overexpressing Multidrug-Resistant Cancer Cells." 10/23/2022 - "We discovered that, in a concentration-dependent manner, hydroxygenkwanin significantly reverses ABCG2-mediated resistance to multiple cytotoxic anticancer drugs in ABCG2-overexpressing multidrug-resistant cancer cells. " 01/01/2020 - "We found that hydroxygenkwanin (HGK), an extract from Daphne genkwa, inhibited class I HDAC expression, and thereby induced expression of tumor suppressor p21 and promoted acetylation and activation of p53 and p65. " 10/01/2022 - "Hydroxygenkwanin (HGK) has an anticancer effect in a variety of tumors, but its role in osteosarcoma has not been explored. " 10/23/2022 - "In this study, we examine the interaction between hydroxygenkwanin, ABCB1, and ABCG2, which are two of the most well-characterized ABC transporters known to contribute to clinical MDR in cancer patients. "
2.	Thrombosis (Thrombus) 04/01/2019 - "Through the study of network pharmacology,12 components of aspirin and Trichosanthis Fructus,including hydroxygenkwanin,quercetin and adenosine,were found to show the anti-platelet aggregation and anti-thrombosis mechanisms through9 common protein targets,such as SRC,RAC1,MAPK14,MAPK1,AKT1,and 14 common signaling pathways,such as VEGF signaling pathway. "
3.	Liver Neoplasms (Liver Cancer) 09/09/2021 - "Hydroxygenkwanin Increases the Sensitivity of Liver Cancer Cells to Chemotherapy by Inhibiting DNA Damage Response in Mouse Xenograft Models." 01/01/2020 - "Hydroxygenkwanin Inhibits Class I HDAC Expression and Synergistically Enhances the Antitumor Activity of Sorafenib in Liver Cancer Cells."
4.	Osteosarcoma (Osteogenic Sarcoma) 10/01/2022 - "Hydroxygenkwanin suppresses proliferation, invasion and migration of osteosarcoma cells via the miR‑320a/SOX9 axis." 10/01/2022 - "Hydroxygenkwanin (HGK) has an anticancer effect in a variety of tumors, but its role in osteosarcoma has not been explored. "
5.	Hepatocellular Carcinoma (Hepatoma) 12/21/2019 - "Suppression of Hepatocellular Carcinoma Progression through FOXM1 and EMT Inhibition via Hydroxygenkwanin-Induced miR-320a Expression."

Related Drugs and Biologics

1.	Mitogen-Activated Protein Kinase 14
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	ATP-Binding Cassette Transporters (ABC Transporters)
4.	Quercetin
5.	Proteins (Proteins, Gene)
6.	Drug Combinations
7.	Aspirin (Acetylsalicylic Acid)
8.	Adenosine (Adenocard)
9.	Apigenin
10.	Adenosine Triphosphatases (ATPase)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)