N-demethylmenogaril

major metabolite of menogaril; RN given refers to (2R-(2alpha,3beta,4alpha,5beta,6alpha,11alpha,13alpha))-isomer

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

1.	Neoplasms (Cancer) 01/01/1993 - "N-Demethylmenogaril was found in two lung-tissue samples and in single samples of the thyroid, lymph node, pancreas, cerebellum, and tumor. " 03/01/1986 - "In vitro activity of menogaril and N-demethylmenogaril in a human tumor cloning assay."
2.	Leukemia P388 11/15/1989 - "To determine if metabolically formed N-demethylmenogaril might contribute to the overall antitumor activity of menogaril, we determined the effect of synthetic N-demethylmenogaril on the life span of mice bearing P388 leukemia. "
3.	Breast Neoplasms (Breast Cancer) 03/01/1986 - "Our data confirm the in vitro activity of menogaril in ovarian and breast cancer; in addition, they suggest incomplete cross-resistance between doxorubicin and menogaril and, considering the concentrations of N-demethylmenogaril in animals and humans, a minor role for this metabolite in the overall antitumor activity of the parent compound."