benzo(a)pyrene 7,8-oxide

RN given refers to cpd without isomeric designation; structure given in first source

Also Known As:

benzo(a)pyrene 7,8-epoxide; benzo(a)pyrene 7,8-oxide, (+-)-isomer; benzo(a)pyrene 7,8-oxide, (6bR)-isomer; benzo(a)pyrene 7,8-oxide, (6bS)-isomer

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

1.	Neoplasms (Cancer) 11/01/1976 - "Application of 7,8-epoxy-,8,9,10-tetrahydrobenzo[a]pyrene (0.30 mumol every 2 weeks), a compound related to the carcinogenic benzo[a]pyrene 7,8-oxide but with the double bond removed from the 9,10-position of the molecule, did not elicit any tumors. " 11/01/1976 - "At the low dose (0.15 mumol), the compound was equipotent to the parent hydrocarbon, benzo[a]pyrene, and considerably more potent than its metabolic precursor, benzo[a]pyrene 7,8-oxide, in eliciting tumors, as determined by both the onset of tumors and the total number of animals developing carcinomas. "
2.	Carcinoma (Carcinomatosis) 11/01/1976 - "At the low dose (0.15 mumol), the compound was equipotent to the parent hydrocarbon, benzo[a]pyrene, and considerably more potent than its metabolic precursor, benzo[a]pyrene 7,8-oxide, in eliciting tumors, as determined by both the onset of tumors and the total number of animals developing carcinomas. "