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kbp-7072

third generation aminomethylcycline

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthacenes
        Tetracyclines: 1162
        kbp-7072: 3
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthacenes
    - Tetracyclines: 1162
      - kbp-7072: 3

Experts

1.	Liu, Qingmei: 3 articles (01/2022 - 01/2019)
2.	Li, Li: 2 articles (01/2022 - 01/2022)
3.	Zhang, Jay: 2 articles (01/2022 - 01/2022)
4.	Castanheira, Mariana: 1 article (01/2022)
5.	Ding, Li: 1 article (01/2022)
6.	Guo, Yan: 1 article (01/2022)
7.	Gurung, Nabina D: 1 article (01/2022)
8.	Han, Renru: 1 article (01/2022)
9.	Hu, Fupin: 1 article (01/2022)
10.	Huband, Michael D: 1 article (01/2022)

Related Diseases

1.	Infections 01/01/2022 - "baumannii isolates collected from different regions of China, regarded as supplementary to KBP-7072 pharmacodynamics data, which is of great significance, as it is promising an alternative treatment in CRAB isolates infections in China." 01/01/2022 - "KBP-7072 is a potential alternative agent for the treatment of infection caused by A. " 01/01/2022 - "The potent activity of KBP-7072, including resistant organism groups, merits further clinical investigation in infections where these organisms are likely to occur." 01/01/2019 - "The goal of present studies was to determine which pharmacokinetic/pharmacodynamic (PK/PD) parameter magnitude correlated with efficacy in the murine pneumonia infection model against Staphylococcus aureus and Streptococcus pneumoniae KBP-7072 pharmacokinetic measurements were performed in plasma and epithelial lining fluid (ELF) at 4-fold-increasing doses from 1 to 256 mg/kg of body weight subcutaneously. "
2.	Bacterial Pneumonia 01/01/2019 - "The results of these experiments will aid in the rational design of dose-finding studies for KBP-7072 in patients with community-acquired bacterial pneumonia (CAP)." 01/01/2022 - "KBP-7072 is a novel broad-spectrum tetracycline (aminomethylcycline) antibacterial in clinical development (oral and intravenous formulations) for the treatment of acute bacterial skin and skin structure infections, community-acquired bacterial pneumonia, and complicated intra-abdominal infections. "
3.	Pneumonia (Pneumonitis) 01/01/2019 - "KBP-7072 is a novel aminomethylcycline antibiotic in clinical development for community-acquired pneumonia. " 01/01/2019 - "Pharmacokinetic/Pharmacodynamic Evaluation of a Novel Aminomethylcycline Antibiotic, KBP-7072, in the Neutropenic Murine Pneumonia Model against Staphylococcus aureus and Streptococcus pneumoniae." 01/01/2019 - "The goal of present studies was to determine which pharmacokinetic/pharmacodynamic (PK/PD) parameter magnitude correlated with efficacy in the murine pneumonia infection model against Staphylococcus aureus and Streptococcus pneumoniae KBP-7072 pharmacokinetic measurements were performed in plasma and epithelial lining fluid (ELF) at 4-fold-increasing doses from 1 to 256 mg/kg of body weight subcutaneously. "
4.	Body Weight (Weight, Body) 01/01/2019 - "The goal of present studies was to determine which pharmacokinetic/pharmacodynamic (PK/PD) parameter magnitude correlated with efficacy in the murine pneumonia infection model against Staphylococcus aureus and Streptococcus pneumoniae KBP-7072 pharmacokinetic measurements were performed in plasma and epithelial lining fluid (ELF) at 4-fold-increasing doses from 1 to 256 mg/kg of body weight subcutaneously. "
5.	Intraabdominal Infections 01/01/2022 - "KBP-7072 is a novel broad-spectrum tetracycline (aminomethylcycline) antibacterial in clinical development (oral and intravenous formulations) for the treatment of acute bacterial skin and skin structure infections, community-acquired bacterial pneumonia, and complicated intra-abdominal infections. "

Related Drugs and Biologics

1.	Tetracycline (Achromycin)
2.	Anti-Bacterial Agents (Antibiotics)