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senexin A

Also Known As:

4-((2-Phenylethyl)amino)-6-quinazolinecarbonitrile

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - senexin A: 3

Experts

1.	Aksu, Merdane Ezgi: 1 article (01/2021)
2.	Bjørås, Magnar: 1 article (01/2021)
3.	Brambilla, Alessandro: 1 article (01/2021)
4.	Erlandsen, Sten Even: 1 article (01/2021)
5.	Fordyce Martin, Sarah L: 1 article (01/2021)
6.	Johansen, Jostein: 1 article (01/2021)
7.	Kunath, Nicolas: 1 article (01/2021)
8.	Liabbak, Nina-Beate: 1 article (01/2021)
9.	Montaldo, Nicola Pietro: 1 article (01/2021)
10.	Rian, Kristin: 1 article (01/2021)

Related Diseases

1.	Vascular Diseases (Vascular Disease) 01/01/2022 - "In this study, we established a novel strategy to locally and sustainably deliver the cyclin-dependent kinase 8/19 inhibitor Senexin A (SenA), an emerging drug candidate to treat occlusive vascular disease, using graphene oxide-hybridised hyaluronic acid-based hydrogels. "
2.	Neoplasms (Cancer) 01/01/2021 - "Importantly, the treatment with Senexin A stabilizes MED13, and in combination with alkylating agents significantly reduces viability of cancer cells. "
3.	Infections 01/01/2020 - "Chemical inhibition of CDK8 and CDK19 with Senexin A during infection blocks virus-induced expression of select metabolic and autophagic genes, hexokinase 2 (HK2) and microtubule-associated protein 1 light chain 3 (LC3), and reduces viral genome replication and infectious particle production. "

Related Drugs and Biologics

1.	Cyclin-Dependent Kinase 8
2.	Hydrogels
3.	Hyaluronic Acid (Hyaluronan)
4.	graphene oxide
5.	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)
6.	Hexokinase
7.	Alkylating Agents