entomophthoromycosis

Also Known As:

Basidiobolus ranarum infection; Conidiobolus coronatus infection; Conidiobolus infection; basidiobolomycosis; conidiobolomycosis; entomophthorales infection; rhinoconidiobolomycosis; rhinoentomophthoramycosis

Networked: 48 relevant articles (8 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Infections: 526564
- Bacterial Infections and Mycoses: 1
  - Mycoses: 11300
    - Zygomycosis: 370
      - entomophthoromycosis: 48

Related Diseases

1.	Infections
2.	Mycetoma
3.	Histoplasmosis
4.	Blastomycosis
5.	Chronic Mucocutaneous Candidiasis

Experts

1.	Dutra, Valéria: 2 articles (10/2018 - 10/2013)
2.	Kumaravel, S: 2 articles (02/2016 - 07/2005)
3.	Khan, Z U: 2 articles (06/2001 - 10/2000)
4.	Endraswari, Pepy Dwi: 1 article (02/2022)
5.	Kawilarang, Arthur Pohan: 1 article (02/2022)
6.	Octora, Metta: 1 article (02/2022)
7.	Batra, Nitya: 1 article (01/2022)
8.	Chatterjee, Debajyoti: 1 article (01/2022)
9.	Chaudhari, Dixit G: 1 article (01/2022)
10.	Chaudhary, Raju G: 1 article (01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to entomophthoromycosis:

1.	Itraconazole (Sporanox)FDA LinkGeneric 01/01/2022 - "Subcutaneous Basidiobolomycosis Treated Successfully with Oral Itraconazole: A Case Report." 01/01/2022 - "But here, we report a rare case of Basidiobolomycosis detected in an immunocompetent patient-without any debilitating illness, which showed a complete response to itraconazole 200 mg daily without any surgical intervention." 03/01/2021 - "We diagnosed the case as Basidiobolomycosis based on clinical features, histopathology, and culture findings, and treated it with itraconazole." 07/01/2005 - "This case report highlights that in an older child even longstanding extensive basidiobolomycosis can be safely treated with itraconazole. " 07/01/2005 - "Successful treatment of extensive basidiobolomycosis with oral itraconazole in a child."
2.	Potassium Iodide (Pima)FDA Link 01/01/2018 - "Gastro-intestinal basidiobolomycosis in a 2-year-old boy: dramatic response to potassium iodide." 01/01/1998 - "Potassium iodide was the drug of choice in the treatment of entomophthoromycosis. " 07/01/2005 - "Basidiobolomycosis is a rare chronic subcutaneous infection caused by Basidiobolus ranarum, which is usually treated with potassium iodide. " 11/01/2015 - "Entomophthoromycosis (basidiobolomycosis) presenting with "saxophone" penis and responding to potassium iodide." 08/01/2021 - "Itraconazole and potassium iodide are reasonable first-line options for the treatment of conidiobolomycosis. "
3.	Ketoconazole (Nizoral)FDA LinkGeneric 12/01/2010 - "We report a case of basidiobolomycosis successfully treated with ketoconazole. " 12/01/2010 - "[Probable basidiobolomycosis in a Togolese rural young successfully treated with ketoconazole]." 09/01/1988 - "Conidiobolus coronatus infection treated with ketoconazole." 04/01/1984 - "These data suggest that ketoconazole may be of use in the treatment of entomophthoromycosis, particularly in cases which are not responsive to KI." 01/01/2017 - "It confirms the efficacy of ketoconazole in severe basidiobolomycosis infection with alteration of general condition. "
4.	Voriconazole (Vfend)FDA LinkGeneric 09/01/2015 - "A Case Report of Gastrointestinal Basidiobolomycosis Treated With Voriconazole: A Rare Emerging Entity." 12/01/2014 - "Successful treatment of gastrointestinal basidiobolomycosis with voriconazole without surgical intervention." 10/01/2013 - "Our case is the first to report effective treatment of pediatric gastrointestinal basidiobolomycosis using voriconazole mono-therapy. " 10/25/2013 - "lamprauges strains isolated from sheep conidiobolomycosis to amphotericin B, ketoconazole, fluconazole, itraconazole, posaconazole, voriconazole, anidulafungin, caspofungin, micafungin, flucytosine, and terbinafine using the CLSI M38-A2 microdilution technique. "
5.	Amphotericin B (Amphotericin)FDA LinkGeneric 01/01/1996 - "Nasopharyngeal conidiobolomycosis may be treated successfully with intralesional injection of amphotericin B in combination with administration of sodium iodide and potassium iodide, but there is a possibility of recrudescence of infection." 10/01/1996 - "The entomophthoromycosis received oral steroids and cotrimoxazole, and oral potassium iodide or intravenous amphotericin in case of relapse. " 07/01/2001 - "Rhinoentomophthoramycosis caused by Conidiobolus coronatus in a 61-year old woman was unsuccessfully treated during 8 years with all the antifungals available in the Brazilian market, including potassium iodide for 1 month, sulfamethoxazole plus trimethoprim for 2 months, amphotericin B, total dose of 1130 mg, cetoconazole, 400 mg/day for 6 months, fluconazole, 200 mg/day, for at least 2 months and, itraconazole, 400 mg/day for 2 months, followed by 200 mg/day for 4 more months. " 10/25/2013 - "lamprauges strains isolated from sheep conidiobolomycosis to amphotericin B, ketoconazole, fluconazole, itraconazole, posaconazole, voriconazole, anidulafungin, caspofungin, micafungin, flucytosine, and terbinafine using the CLSI M38-A2 microdilution technique. "
6.	Antifungal AgentsIBA 07/01/2012 - "Although rhinoentomophthoramycosis ostensibly responds in vivo to most available antifungal agents, routine culture and susceptibility testing is recommended to better define the efficacy of these therapeutic agents." 04/01/1984 - "Of the antifungal agents tested, the imidazole derivatives, especially ketoconazole, were the most active against the agents of entomophthoromycosis. " 01/01/1982 - "Among the new imidazole derivatives, ketoconazole (400 mg/day) represent a revolutionary antifungal agent due to a very large antifungal spectrum, absence of toxicity, rapid diffusion by oral way, and high therapeutic efficiency in candidosis, histoplasmosis, blastomycosis, rhino-entomophthoromycosis... "
7.	AzolesIBA 12/01/2010 - "Treatment of basidiobolomycosis is based on azole derivatives which are particularly effective. " 01/01/2019 - "We report a case of gastrointestinal basidiobolomycosis masquerading as colonic malignancy in a 29-year-old Omani patient successfully treated with combination of surgery and prolonged azole antifungal therapy."
8.	Sodium IodideIBA 01/01/1996 - "Nasopharyngeal conidiobolomycosis may be treated successfully with intralesional injection of amphotericin B in combination with administration of sodium iodide and potassium iodide, but there is a possibility of recrudescence of infection."
9.	Peptide Hydrolases (Proteases)FDA Link 10/01/2022 - "CCs that inhibit the activity of lipases and proteases show promise in the fight against conidiobolomycosis."
10.	Heroin (Diamorphine)IBA 01/24/1983 - "Excellent results were obtained in six cases of chronic mucocutaneous candidiasis, with restoration of immunologic disturbances; 23 cases of systemic candidiasis, including new aspects of heroin addicts with cutaneous, ocular, or osteoarticular manifestations; eight cases of histoplasmosis, five due to Histoplasma capsulatum and three to Histoplasma duboisii, with cure in seven and remission in one; one case of African blastomycosis (Blastomyces dermatitidis); three cases of mycetoma, two due to Monosporium apiospermum, one due to a dematiacious fungus; three cases of entomophthoromycosis with cure; one case of fungal arthritis, due to new hyphomycete similar to M. "

Therapies and Procedures

1.	Therapeutics 10/04/2018 - "The in vitro activities suggest that the combination of MTF and AZI or DAP are promising candidate therapies for conidiobolomycosis." 07/01/2012 - "To present an exemplary case report and perform a systematic review of the world's literature to more accurately describe the natural history and the effect of therapy on outcome in conidiobolomycosis. " 10/01/2018 - "Successful Treatment of Invasive Conidiobolus Infection During Therapy for Acute Lymphoblastic Leukemia." 09/01/1994 - "Therapy of entomophthoromycosis is also difficult because the diagnosis is usually established late and not all patients respond to therapy; this situation applies to infection caused by either Basidiobolus haptosporus or Conidiobolus coronatus. " 10/01/2013 - "Our case is the first to report effective treatment of pediatric gastrointestinal basidiobolomycosis using voriconazole mono-therapy. "
2.	Intralesional Injections 01/01/1996 - "Nasopharyngeal conidiobolomycosis may be treated successfully with intralesional injection of amphotericin B in combination with administration of sodium iodide and potassium iodide, but there is a possibility of recrudescence of infection."
3.	Induction Chemotherapy 05/01/2005 - "Severe conidiobolomycosis complicating induction chemotherapy in a patient with acute lymphoblastic leukaemia."
4.	Peritoneal Dialysis 10/01/2000 - "Basidiobolomycosis of the rectum in a Bangladeshi male, cryptococcosis due to Cryptococcus neoformans var. gatti in an AIDS patient,fungal peritonitis due to Absidia corymbifera in a patient on peritoneal dialysis, and endocarditis due to Aspergillus terreus detected by direct microscopic examination and culture of the blood clot are some of the notable cases diagnosed during the period under review. "
5.	Immunotherapy 01/01/2021 - "Refractory thoracic conidiobolomycosis treated with mepolizumab immunotherapy."