In vitro susceptibility of Conidiobolus lamprauges recovered from sheep to antifungal agents.

Abstract

Data regarding the susceptibility of Conidiobolus lamprauges is limited and there is no consensus about the optimal treatment for infections caused by Conidiobolus spp. In this context, the objective of this study was to evaluate the in vitro susceptibility of six C. lamprauges strains isolated from sheep conidiobolomycosis to amphotericin B, ketoconazole, fluconazole, itraconazole, posaconazole, voriconazole, anidulafungin, caspofungin, micafungin, flucytosine, and terbinafine using the CLSI M38-A2 microdilution technique. Terbinafine was the most active (MIC range <0.06-0.5 μg/mL). Resistance or reduced susceptibility was observed for amphotericin B and azole and echinocandin antifungals. Additional studies are necessary to determine the therapeutic potential of terbinafine as monotherapy or in combination therapy with other antifungals.

• Authors: Juliana Simoni Moraes Tondolo, Érico Silva de Loreto, Valéria Dutra, Luciano Nakazato, Daphine Ariadne Jesus de Paula, Régis Adriel Zanette, Sydney Hartz Alves, Janio Morais Santurio
• Journal: Veterinary microbiology (Vet Microbiol) Vol. 166 Issue 3-4 Pg. 690-3 (Oct 25 2013) ISSN: 1873-2542 [Electronic] Netherlands
• PMID: 23958402 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier B.V. All rights reserved.

Chemical References

• Antifungal Agents

Topics

• Animals
• Antifungal Agents (pharmacology)
• Conidiobolus (drug effects, genetics, isolation & purification)
• Microbial Sensitivity Tests
• Sheep
• Sheep Diseases (drug therapy, microbiology)
• Zygomycosis (drug therapy, microbiology, veterinary)