HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

5- (2- oxopropylideneamino)- 6- d- ribitylaminouracil

microbial metabolite

Also Known As:

5-OP-RU

Networked: 9 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Alcohols: 595
  - Sugar Alcohols: 143
    - Ribitol: 68
      - 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil: 9
Carbohydrates: 22023
- Sugar Alcohols: 143
  - Ribitol: 68
    - 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil: 9
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - Uracil: 1493
        5-(2-oxopropylideneamino)-6-d-ribitylaminouracil: 9

Experts

1.	Fairlie, David P: 5 articles (01/2021 - 11/2019)
2.	Mak, Jeffrey Y W: 5 articles (01/2021 - 11/2019)
3.	Chen, Zhenjun: 3 articles (01/2021 - 11/2019)
4.	Corbett, Alexandra J: 3 articles (01/2021 - 11/2019)
5.	Liu, Ligong: 3 articles (01/2021 - 01/2020)
6.	Meehan, Bronwyn S: 3 articles (01/2021 - 11/2019)
7.	Barber, Daniel L: 2 articles (01/2021 - 01/2021)
8.	Eckle, Sidonia B G: 2 articles (01/2021 - 11/2019)
9.	Kauffman, Keith D: 2 articles (01/2021 - 01/2021)
10.	Lim, Xin Yi: 2 articles (01/2021 - 11/2019)

Related Diseases

1.	Infections 01/01/2021 - "Indeed, a systemic vaccination with synthetic antigen 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil in combination with CpG adjuvant similarly boosts MAIT cells, and results in enhanced protection against both systemic and local infections with different bacteria. " 11/15/2019 - "Vaccination with IL-23 plus 5-OP-RU augments MAIT cell-mediated control of pulmonary Legionella infection. " 01/01/2020 - "Nevertheless, the only known ligand for CXCR6, CXCL16, is sufficient to drive MAIT cell accumulation in the lungs in the absence of infection when administered in combination with the MAIT cell antigen 5-OP-RU. "
2.	Neoplasms (Cancer) 01/01/2021 - "5-OP-RU activates MAIT cells and, like a vaccine, has been shown to protect mice from bacterial infections and cancers. " 01/01/2020 - "Pretreatment of tumor cells with the stimulatory ligand 5-OP-RU or inhibitory ligand Ac-6-FP increased or decreased lung metastases, respectively. "
3.	Tuberculosis (Tuberculoses) 01/01/2021 - "tuberculosis infected rhesus macaques with 5-OP-RU intratracheally but found no clinical or microbiological benefit. "
4.	Neoplasm Metastasis (Metastasis) 01/01/2020 - "Pretreatment of tumor cells with the stimulatory ligand 5-OP-RU or inhibitory ligand Ac-6-FP increased or decreased lung metastases, respectively. "
5.	Liver Diseases (Liver Disease) 01/01/2019 - "MR1 tetramers loaded with a potent MAIT cell ligand 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil were used in multiparameter flow cytometry to analyze peripheral blood MAIT cells in 59 healthy controls (HC), 56 patients with AH, and 45 heavy drinkers without overt liver disease (HDC) at baseline and 6- and 12-month follow-ups. "

Related Drugs and Biologics

1.	Synthetic Vaccines (Recombinant Vaccines)
2.	Ligands
3.	Interleukin-23 (Interleukin 23)
4.	Viral Vaccines
5.	Vaccines
6.	Riboflavin (Vitamin B2)
7.	Antigens