6-sulfo sialyl Lewis X

carbohydrate moiety epitpe of post-translationally modified P-selectin ligand PSGL-1 that makes PSGL-1 act as a skin-selective homing receptor on memory T LYMPHOCYTES; sulfated derivative of sialated Lewis X antigen

Also Known As:

Networked: 147 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kobayashi, Motohiro: 5 articles (10/2017 - 01/2009)
2.	Valdimarsson, H: 4 articles (10/2013 - 11/2001)
3.	Alaibac, Mauro: 3 articles (04/2022 - 01/2020)
4.	Russo, Irene: 3 articles (04/2022 - 01/2020)
5.	Celada, Antonio: 3 articles (02/2021 - 01/2016)
6.	Ferran, Marta: 3 articles (02/2021 - 01/2016)
7.	Ruiz-Romeu, Ester: 3 articles (02/2021 - 01/2016)
8.	Czarnowicki, Tali: 3 articles (01/2019 - 10/2015)
9.	Estrada, Yeriel: 3 articles (01/2019 - 10/2015)
10.	Guttman-Yassky, Emma: 3 articles (01/2019 - 10/2015)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2014 - "We concluded that the relative immunosuppressive effects of PD1 may contribute to tumor progression while the lack of staining for cutaneous lymphocyte antigen may be an additional factor facilitating distant extracutaneous migration." 09/01/2008 - "Cutaneous lymphocyte antigen was absent and EMA/MUC1, typical of systemic ALCL, was strongly expressed by the tumor cells. " 08/01/2008 - "We also developed the assay system for CD44v modified by normal epithelial glycotopes including disialyl Lewis a and sialyl 6-sulfo Lewis x. The results indicated that serum levels of soluble CD44v modified by cancer-associated glycotopes were frequently increased in patients with cancers, while those of CD44v modified by the nonmalignant glycotopes tended to be elevated in patients with benign disorders." 09/01/1998 - "Human N-acetylglucosamine-6-O-sulfotransferase involved in the biosynthesis of 6-sulfo sialyl Lewis X: molecular cloning, chromosomal mapping, and expression in various organs and tumor cells." 01/01/1997 - "The tumor cells show CD3, CD4 and CLA, (cutaneous lymphocyte associated antigen) positivity. "
2.	Lymphoma (Lymphomas) 09/01/2014 - "CCL27 was expressed in the dermis generated from keratinocytes, CCR4/CCR6/CCR7/CCR10/cutaneous lymphocyte-associated antigen (CLA) lymphoma cells in the dermis, and CCL21 in the extracellular matrix (stroma). " 07/15/2010 - "NK-cell lymphoma with nodal presentation and expression of cutaneous lymphocyte-associated antigen." 01/01/2003 - "Natural killer cells in human peripheral blood and primary cutaneous natural killer cell lymphomas may express cutaneous lymphocyte antigen." 08/01/2002 - "We examined the expression of cutaneous lymphocyte antigen (CLA) in 52 cases of NK-cell lymphoma. " 08/01/2002 - "Expression of cutaneous lymphocyte antigen is associated with a poor outcome of nasal-type natural killer-cell lymphoma."
3.	Cutaneous T-Cell Lymphoma (Lymphoma, T Cell, Cutaneous) 12/01/2002 - "In this study we analyzed the pattern of coexpression of the skin-homing molecules cutaneous lymphocyte antigen (CLA) and CCR4 in the blood and skin of patients with cutaneous T cell lymphoma. " 12/01/2022 - "Cutaneous Lymphocyte Antigen Is a Potential Therapeutic Target in Cutaneous T-Cell Lymphoma." 04/01/2022 - "Cutaneous lymphocyte antigen is a potential molecular target for NIR-PIT for both cutaneous T-cell lymphomas and inflammatory skin disorders." 08/01/2002 - "Cutaneous lymphocyte antigen (CLA) has been reported to be expressed mainly by memory/effector T lymphocytes infiltrating inflammatory skin lesions and cutaneous T-cell lymphoma. " 05/01/2001 - "Cutaneous lymphocyte-associated antigen (CLA) is a lymphocyte homing receptor selectively expressed by T cells of the cutaneous immune system and their malignant counterpart, that is to say, cutaneous T-cell lymphomas. "
4.	Asthma (Bronchial Asthma) 01/01/2019 - "Previous studies have shown that the proportion of CCR4+ memory Th cells expressing sialyl 6-sulfo Lewis X (LeX) is elevated in asthma patients. " 10/01/1996 - "As the cutaneous lymphocyte-associated antigen appears to detect circulating T cells that migrate to the skin in atopic dermatitis but not T cells that migrate to mucosal sites in allergic asthma and rhinitis, we investigated T-cell activation markers and CD30 on the cutaneous lymphocyte-associated antigen-positive circulating T-cell subset in atopic dermatitis to see whether these markers are different from those in normal controls and related to disease activity. "
5.	Lymphomatoid Papulosis 10/01/2001 - "Expression of cutaneous lymphocyte-associated antigen and TIA-1 by lymphocytes in pityriasis lichenoides et varioliformis acuta and lymphomatoid papulosis: immunohistochemical study."

Related Drugs and Biologics

1.	E-Selectin
2.	Ligands
3.	Antigens
4.	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)
5.	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)
6.	Chemokine CCL27
7.	Integrin alpha4beta1 (VLA-4)
8.	Cytokines
9.	Superantigens
10.	L-Selectin

Related Therapies and Procedures

1.	Therapeutics
2.	Biological Therapy