Abstract |
In normal human peripheral blood, cutaneous lymphocyte antigen is expressed by memory T cells, suggesting a specific tissue-homing population of T cells. In this study it is demonstrated that 6% of CD56 + natural killer cells in peripheral blood also express cutaneous lymphocyte antigen (CLA). It was also detected that most of the tumor cells in primary cutaneous nasal-type natural killer cell lymphomas were CLA-positive, whereas primary nasal natural killer cell lymphomas were CLA-negative. Although natural killer cells traditionally are known to be non-specific immune cells without antigen specificity and little is known about the role of natural killer cells in skin diseases, the results of this study suggest the existence of a subset of skin-associated CLA+ CD56+ natural killer cells. These natural killer cells may be related to the pathogenesis of primary cutaneous natural killer cell lymphomas.
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Authors | Sung-Eun Chang, Mi-Jung Kim, Won-Sin Lee, Yoon-Koo Kang, Kee-Chan Moon, Jai-Kyoung Koh, Jee-Ho Choi |
Journal | Acta dermato-venereologica
(Acta Derm Venereol)
Vol. 83
Issue 3
Pg. 162-6
( 2003)
ISSN: 0001-5555 [Print] Sweden |
PMID | 12816147
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Antigens
(immunology)
- CD56 Antigen
(immunology)
- Female
- Humans
- Killer Cells, Natural
(immunology)
- Lymphocytes
(immunology)
- Lymphoma, T-Cell, Cutaneous
(immunology)
- Male
- Middle Aged
- Skin
(immunology)
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