cyclohexyl 2,7,7- trimethyl- 4- (4- nitrophenyl)- 5- oxo- 1,4,5,6,7,8- hexahydroquinoline- 3- carboxylate

01/01/2019 - "The aim of this study was to inhibit the proliferation and self-renewal of tongue cancer cells by applying Notch signaling pathway inhibitor FLI-06 (Selleck, USA) and to lay a foundation for the clinically targeted treatment of tongue cancer for the future. "
01/01/2019 - "FLI-06 can block the proliferation and self-renewal of tongue cancer cells. "
01/01/2019 - "We also observed that FLI-06 suppressed the proliferation of tongue cancer stem cells. "
01/01/2019 - "Tongue cancer cells were treated with FLI-06. "
01/01/2019 - "FLI-06 Intercepts Notch Signaling And Suppresses The Proliferation And Self-renewal Of Tongue Cancer Cells."

01/01/2019 - "The xenograft experiment indicated that intraperitoneal injection of FLI-06 inhibited tumor growth and increased cell apoptosis. "
11/01/2018 - "Interestingly, we also found that the expression of LSD1 (histone lysine specific demethylase 1), which is dysregulated in multiple tumors, was also inhibited by FLI-06. "
11/01/2018 - "To evaluate the anti-tumor activity and possible molecular mechanism of FLI-06 to ESCC cells, the effects of FLI-06 on cell viability, apoptosis and cell cycle were evaluated by CCK-8 and flow cytometry assays, respectively, in ESCC cell lines ECa109 and EC9706, and the expressions of proteins in Notch signaling pathway and LSD1 were investigated after cells were treated with FLI-06 by Western blotting. "

01/01/2017 - "An ovalbumin-induced food allergy mouse model was built (cholera toxin as adjuvant) and Notch signaling was blunted by FLI-06 and MW167, which inhibited Notch receptor-expressing phase and the γ-secretase-affecting phase, respectively. "

01/01/2017 - "The use of DAPT and FLI-06 reduced both fibrosis markers in Ps but not in Cs. "

09/01/2020 - "The liver/body weight ratios and number of Ki-67- and PCNA-positive cells were significantly lower in the experimental group than the control group, indicating lower levels of liver regeneration following the disruption of Notch signaling by Fli-06. "