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N- benzyloxycarbonyl- alanyl- alanyl- aspartyl- doxorubicin

a doxorubicin prodrug; structure in first source

Also Known As:

CBZ-AAN-Dox; N-benzyloxycarbonyl-Ala-Ala-Asn-doxorubicin

Networked: 2 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rui, Wen: 2 articles (01/2020 - 10/2015)
2.	Chen, Hong-Ce: 1 article (01/2020)
3.	Chen, Hong-Yuan: 1 article (01/2020)
4.	Huang, Jun: 1 article (01/2020)
5.	Liu, Xia-Wan: 1 article (01/2020)
6.	You, Si-Yuan: 1 article (01/2020)
7.	Chen, Hongyuan: 1 article (10/2015)
8.	Clayman, Eric S: 1 article (10/2015)
9.	Fu, Wuyu: 1 article (10/2015)
10.	Liu, Xiao: 1 article (10/2015)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "The difficulty to test the safety and efficacy of the prodrug (including the pharmacodynamic parameters of CBZ-AAN-DOX on metastasis and invasion of tumors, as well as cardiac and vascular toxicity) primarily comes from the lack of appropriate experimental models. " 10/01/2015 - "Our study presents a novel prodrug, CBZ-AAN-Dox, to potentially increase both the safety and efficacy of clinical treatment of tumors by exploiting the tumor's innate expression of legumain. " 01/01/2020 - "CBZ-AAN-DOX is essentially Doxorubicin that is chemically-modified with tripeptides to target Legumain, a highly expressed protein in cancer cells and is involved in tumor metastasis and tumor microvessel formation. "
2.	Neoplasm Metastasis (Metastasis) 01/01/2020 - "The difficulty to test the safety and efficacy of the prodrug (including the pharmacodynamic parameters of CBZ-AAN-DOX on metastasis and invasion of tumors, as well as cardiac and vascular toxicity) primarily comes from the lack of appropriate experimental models. " 01/01/2020 - "CBZ-AAN-DOX is essentially Doxorubicin that is chemically-modified with tripeptides to target Legumain, a highly expressed protein in cancer cells and is involved in tumor metastasis and tumor microvessel formation. "
3.	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/01/2020 - "The findings in this study demonstrated that CBZ-AAN-DOX is a promising chemotherapy candidate with low toxicity and high efficiency for cervical cancer. " 10/01/2015 - "Synthesis and Evaluation of a CBZ-AAN-Dox Prodrug and its in vitro Effects on SiHa Cervical Cancer Cells Under Hypoxic Conditions."

Related Drugs and Biologics

1.	Prodrugs
2.	asparaginylendopeptidase (legumain)
3.	Proteins (Proteins, Gene)
4.	Doxorubicin (Adriamycin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)