aceroside VIII

an HDAC6 inhibitor with hepatoprotective activity; isolated from Betula platyphylla; structure in first source

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

1.	Colonic Neoplasms (Colon Cancer) 05/28/2016 - "A simple and rapid method using high-speed counter-current chromatography (HSCCC), along with bioassay-guided fractionation based on the anti-proliferative activity against renal and colon cancer cells, has been developed for the preparative separation of aceroside VIII (1) and platyphylloside (2) from Betula platyphylla. " 02/01/2015 - "Together, these findings indicate that aceroside VIII is a specific histone deacetylase 6 inhibitor and points to a mechanism by which natural histone deacetylase 6-selective inhibitors may enhance the efficacy of other histone deacetylase 6 inhibitors in colon cancer cells. "
2.	Body Weight (Weight, Body) 11/15/2012 - "platyphylla bark (100mg/kg body weight), aceroside VIII (1mg/kg body weight) and platyphylloside (1 or 2mg/kg body weight) significantly ameliorated scopolamine-induced amnesia in passive avoidance test. "
3.	Amnesia (Dissociative Amnesia) 11/15/2012 - "platyphylla bark (100mg/kg body weight), aceroside VIII (1mg/kg body weight) and platyphylloside (1 or 2mg/kg body weight) significantly ameliorated scopolamine-induced amnesia in passive avoidance test. "

1.	Histone Deacetylases (Histone Deacetylase)
2.	Histone Deacetylase 6
3.	platyphylloside
4.	Scopolamine (Hyoscine)