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5- (3- hydroxy- 4- methoxyphenyl)- 4- (3,4,5- trimethoxyphenyl)- 3H- 1,2- dithiol- 3- one

a microtubule inhibitor with antineoplastic activity; structure in first source

Also Known As:

COH-203

Networked: 2 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - 5-(3-hydroxy-4-methoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-3H-1,2-dithiol-3-one: 2

Experts

1.	Bao, Kai: 1 article (12/2021)
2.	Guan, Qi: 1 article (12/2021)
3.	Lin, Jihong: 1 article (12/2021)
4.	Wang, Zhiwei: 1 article (12/2021)
5.	Wu, Lan: 1 article (12/2021)
6.	Zhang, Lei: 1 article (12/2021)
7.	Bai, Zhao-Shi: 1 article (12/2014)
8.	Li, Zeng-Qiang: 1 article (12/2014)
9.	Qi, Huan: 1 article (12/2014)
10.	Shen, Qi-Rong: 1 article (12/2014)

Related Diseases

1.	Liver Neoplasms (Liver Cancer) 12/12/2014 - "COH-203 was shown to be more effective in inhibiting the proliferation of liver cancer cells compared with normal liver cells. " 12/12/2014 - "Mechanistic studies demonstrated that treatment with COH-203 induced mitotic arrest by inhibiting tubulin polymerization in BEL-7402 liver cancer cells. "
2.	Acute Promyelocytic Leukemia 12/01/2021 - "In the present study, it was demonstrated that COH-203 had notable time- and dose-dependent antiproliferative effects on the human acute promyelocytic leukemia HL-60 cell line. "
3.	Leukemia 12/01/2021 - "The sensitivity of human acute leukemia cell lines to COH-203, and the mechanism underlying its anti-proliferative effects remain unknown, which was investigated in the present study. " 12/01/2021 - "G2/M cell cycle arrest and apoptosis induced by COH-203 in human promyelocytic leukemia HL-60 cells."
4.	Hepatocellular Carcinoma (Hepatoma) 12/12/2014 - "In this study, we evaluated the anti-hepatoma effect of COH-203 in vitro and in vivo and explored the underlying molecular mechanisms. " 12/12/2014 - "COH-203 also displayed potent anti-tumor activity in a hepatocellular carcinoma xenograft model without significant toxicity. " 12/12/2014 - "COH-203, a novel microtubule inhibitor, exhibits potent anti-tumor activity via p53-dependent senescence in hepatocellular carcinoma."
5.	Neoplasms (Cancer) 12/12/2014 - "Our findings will provide a molecular rationale for the development of COH-203 as a promising anti-tumor agent. " 12/12/2014 - "COH-203 also displayed potent anti-tumor activity in a hepatocellular carcinoma xenograft model without significant toxicity. " 12/12/2014 - "COH-203, a novel microtubule inhibitor, exhibits potent anti-tumor activity via p53-dependent senescence in hepatocellular carcinoma."

Related Drugs and Biologics

1.	Tubulin