Tryptophan (L-Tryptophan)

An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.

Also Known As:

Networked: 6967 relevant articles (224 outcomes, 797 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Fuchs, Dietmar: 98 articles (11/2023 - 09/2002)
2.	Maes, Michael: 60 articles (11/2023 - 09/2002)
3.	Guillemin, Gilles J: 43 articles (05/2023 - 01/2003)
4.	Juhász, Csaba: 40 articles (11/2023 - 04/2002)
5.	Midttun, Øivind: 31 articles (01/2023 - 05/2009)
6.	Anderson, George: 30 articles (01/2023 - 01/2012)
7.	Platten, Michael: 29 articles (11/2023 - 11/2005)
8.	Mittal, Sandeep: 27 articles (04/2021 - 11/2009)
9.	Muzik, Otto: 26 articles (11/2023 - 04/2002)
10.	Ueland, Per M: 25 articles (11/2023 - 05/2009)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - "Tryptophan (Trp) metabolism is an important target in immuno-oncology as it represents a powerful immunosuppressive mechanism hijacked by tumors for protection against immune destruction. " 01/01/2020 - "MC38 tumors expressed IDO1, which could have limited the efficacy of anti-PD1 in wild-type mice and could have been overcome in TDO-KO mice due to the high levels of tryptophan. " 01/22/2019 - "Furthermore, strategies that modify tryptophan metabolism, effectively inhibiting tumor progression, may be more effective for CRC treatment." 06/16/2022 - "Collectively, results highlight the therapeutic efficacy of the tryptophan auxotrophic ST in an aggressive metastatic cancer model." 10/01/2022 - "The current studies associated with tumor biology continue to describe a high correlation between tryptophan (Trp) metabolism and tumor progression. "
2.	Sleep Initiation and Maintenance Disorders (Insomnia) 07/01/2016 - "The reduction in the Athens Insomnia Scale score in the tryptophan group was significantly greater than that in the placebo group (P = 0.017). " 07/01/1975 - "[Efficacy of the oral treatment with L-tryptophan in subjects with insomnia. " 03/15/2002 - "In the present study the impact of tryptophan depletion on polysomnographically recorded sleep in patients with primary insomnia was studied. " 04/01/1977 - "Studies in rats, normal human subjects, and subjects with mild insomnia all demonstrate that L-tryptophan reduces sleep latency. " 11/15/2018 - "The tryptophan hydroxylase-2 gene polymorphism rs4290270 may not be a susceptibility locus for primary insomnia in Han Chinese, but it may be a marker of depressive symptoms."
3.	Inflammation (Inflammations) 01/01/2018 - "Metabolites of L-tryptophan activate AhR, which confers protection against intestinal inflammation. " 12/28/2022 - "The study aims to elucidate the potential modulating roles of tryptophan to protect against intestinal inflammation and elucidate the underlying molecular mechanisms. " 01/01/2022 - "In conclusion, the study discovered that Rg1 can protect the intestinal barrier and alleviate colon inflammation in UC mice, and the underlying mechanism is closely related to the regulation of gut microbiota composition and microbial tryptophan metabolism." 02/06/2017 - "This study highlights the role of tryptophan in dampening intestinal inflammation in susceptible hosts." 01/01/2017 - "In this study, we provide evidence that ISX mediates a positive feedback loop integrating inflammation, tryptophan catabolism, and immune suppression. "
4.	Colitis 05/23/2024 - "Our study showed that SYD ameliorates damp-heat colitis by restructuring gut microbiota structure, enhancing the metabolism of tryptophan associated with gut microbiota to activate the AHR/IL-22/STAT3 pathway, thereby recovering damaged intestinal mucosa. " 12/01/2017 - "Administration of tryptophan and some of its metabolites reduces the severity of colitis in mice, whereas removing tryptophan from the diet increases susceptibility to colitis. " 12/25/2022 - "Further studies revealed that these beneficial effects were associated with the inhibition of Akt, p-38, ERK, and JNK phosphorylation in the colon tissues, regulating the structure and abundance of the gut microbiota, and modulating the host-microbe tryptophan metabolism of the mice with chronic colitis. " 01/01/2017 - "Thus, we conducted this study to investigate whether dietary tryptophan supplementation protects against DSS-induced colitis by acting through Ahr. " 05/23/2024 - "Shaoyao decoction improves damp-heat colitis by activating the AHR/IL-22/STAT3 pathway through tryptophan metabolism driven by gut microbiota."
5.	Pain (Aches) 04/01/1989 - "No significant reduction in pain was noted in the groups receiving tryptophan and dietary manipulation compared with control groups." 01/01/1984 - "After dietary manipulation including L-tryptophan supplementation 3 subjects out of 11 showed a significant reduction of experimentally induced ischemic pain. " 01/01/1983 - "Over the 4 weeks of the study, there was a greater reduction in reported clinical pain and a greater increase in pain tolerance threshold in the tryptophan group than in the placebo group. " 07/26/2018 - "The tryptophan moiety provides a new pharmacophoric scaffold for the design of highly potent modulators of TRPM8-mediated pain." 01/01/2012 - "Lowered plasma tryptophan may be associated with enhanced pain, autonomic nervous system responses, gut motility, peripheral nerve function, ventilation, and cardiac dysfunctions. "

Related Drugs and Biologics

1.	Kynurenine
2.	Amino Acids
3.	Serotonin (5 Hydroxytryptamine)
4.	Enzymes
5.	Proteins (Proteins, Gene)
6.	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)
7.	Melatonin
8.	Lysine (L-Lysine)
9.	Histidine (L-Histidine)
10.	Arginine (L-Arginine)

Related Therapies and Procedures

1.	Therapeutics
2.	Phototherapy (Light Therapy)
3.	Immunotherapy
4.	Protein-Restricted Diet (Diet, Protein Restricted)
5.	Lenses