Arginine (L-Arginine)

An essential amino acid that is physiologically active in the L-form.

Also Known As:

L-Arginine; Arginine Hydrochloride; Arginine, L-Isomer; DL-Arginine Acetate, Monohydrate; Arginine, L Isomer; DL Arginine Acetate, Monohydrate; Hydrochloride, Arginine; L Arginine; L-Isomer Arginine; Monohydrate DL-Arginine Acetate

Networked: 12160 relevant articles (704 outcomes, 1701 trials/studies)

Relationship Network

Drug Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 31329

Experts

1.	Wu, Guoyao: 63 articles (01/2024 - 03/2004)
2.	Morris, Claudia R: 34 articles (04/2024 - 07/2003)
3.	Schwedhelm, Edzard: 33 articles (11/2023 - 01/2003)
4.	Deutz, Nicolaas E P: 33 articles (12/2022 - 02/2002)
5.	Böger, Rainer H: 30 articles (11/2023 - 01/2003)
6.	Tsikas, Dimitrios: 30 articles (11/2023 - 01/2003)
7.	Bomalaski, John S: 28 articles (01/2023 - 04/2002)
8.	Cynober, Luc: 25 articles (10/2023 - 03/2003)
9.	Knuckey, Neville W: 23 articles (09/2022 - 06/2015)
10.	Meloni, Bruno P: 23 articles (07/2022 - 06/2015)

Related Diseases

1.	Neoplasms (Cancer) 07/01/1992 - "The final tumor weight of rats which received the arginine-containing regimen (19.8 +/- 5.7 g, n = 4) (P less than 0.05) was significantly greater than the tumor weight of rats fed chow ad libitum (12.1 +/- 3.3 g, n = 6). " 01/01/2018 - "In conclusion, aberrant elevated SLC25A29 in cancer functioned to transport more arginine into mitochondria, improved mitochondria-derived NO levels, thus modulated metabolic status to facilitate increased cancer progression." 06/01/2002 - "The results showed the enhancing effect of charge on anti-tumor activity and internalization, and suggested that the replacement of D24 and E88 of cSBL with arginine is more effective than that of E97. " 12/01/2022 - "These results indicate that chemoimmunotherapy was less effective in cancer-bearing aged mice, but that L-arginine supplementation can modulate its therapeutic efficacy via its effect on tumor-specific CTLs." 01/01/2020 - "WDR5 is also a promising target for pharmacological inhibition in cancer, with small molecule inhibitors of an arginine-binding pocket of WDR5 (the 'WIN' site) showing efficacy against a range of cancer cell lines in vitro. "
2.	Dentin Sensitivity 03/01/2013 - "The results of this study support the conclusion that the Arginine Mouthwash provides a significant reduction in dentin hypersensitivity after eight weeks of product use as compared to a Negative Control mouthwash." 10/01/2016 - "The arginine-based approach provided significantly greater dentin hypersensitivity (DH) relief after non-surgical periodontal treatment (NST) when compared to the control. " 01/01/2019 - "To assess the efficacy of 8% arginine containing prophylaxis products over 24 weeks in subjects with dentin hypersensitivity (DH). " 01/01/2019 - "Efficacy of 8% arginine on dentin hypersensitivity: A multicenter clinical trial in 273 patients over 24 weeks." 10/01/2016 - "Dentin hypersensitivity reduction using an arginine-based approach after non-surgical periodontal treatment."
3.	Inflammation (Inflammations) 06/01/2008 - "In this study, we report protective effects of dietary L-arginine (L-Arg) supplementation against oxidative stress and inflammation in aging rats during exhaustive exercise. " 11/01/2023 - "Lactobacillus plantarum ameliorates NASH-related inflammation by upregulating L-arginine production." 01/01/2020 - "Arginine has been shown to improve healing and to modulate inflammation and immune response. " 04/01/2014 - "Mice orally administered with arginine in combination with the probiotic bifidobacteria LKM512 long-term showed suppressed inflammation, improved longevity, and protection from age-induced memory impairment. " 09/01/2013 - "Arg1 ablation in the lung improved peripheral lung function and affected arginine metabolism but had little effect on airway inflammation. "
4.	Infections 11/01/2021 - "Preoperative immunonutrition with an L-arginine-based supplement is associated with significant reduction in postoperative infection, one of the most common complications of RC." 01/01/1991 - "Arginine, as a T cell stimulator, markedly improved immune function and decreased susceptibility to infection of BDL rats." 12/01/1995 - "However, the safety and efficacy of higher doses of arginine supplementation following infection have not been investigated completely. " 06/01/2012 - "L-arginine improved mucosal histology after the infection. " 01/01/2020 - "In this study, we tried to survey the inhibitory impact of ARG by nor-NOHA (N-ω-hydroxy-L-nor-arginine) on in vivo infection caused by L. tropica. "
5.	Ischemia 11/01/2018 - "Histologic findings also demonstrated a significant reduction of ischemia/reperfusion-induced muscle injury when L-Arginine was administered. " 07/01/2003 - "L-arginine's protective effect on cerebrovascular ischemia shows a dose dependent effect on infract size and tissue water content that may prove beneficial in the treatment of ischemia. " 07/01/1994 - "Of those treated with high-dose nitro-arginine and which survived ischemia and seven days' reperfusion, no significant reduction in CA1 injury was detected. " 01/01/2008 - "Protective effects of L-arginine on rat terminal ileum subjected to ischemia/reperfusion." 01/01/2022 - "Taken together, exercise preconditioning and l-arginine supplementation improved left ventricular function following ischemia-reperfusion by stress oxidative mitigation and angiogenesis amelioration."

Related Drugs and Biologics

1.	Nitric Oxide (Nitrogen Monoxide)
2.	Glutamine (L-Glutamine)
3.	Proteins (Proteins, Gene)
4.	Calcium Carbonate (Limestone)
5.	Nitric Oxide Synthase (NO Synthase)
6.	Amino Acids
7.	Citrulline
8.	Glycine (Aminoacetic Acid)
9.	Lysine (L-Lysine)
10.	Dentifrices (Dentifrice)

Related Therapies and Procedures

1.	Therapeutics
2.	Enteral Nutrition (Feeding, Tube)
3.	Oral Administration
4.	Immunotherapy
5.	Length of Stay