Iron

A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.

Also Known As:

Networked: 49319 relevant articles (2284 outcomes, 7056 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ganz, Tomas: 155 articles (04/2024 - 10/2002)
2.	Nemeth, Elizabeta: 133 articles (04/2024 - 04/2003)
3.	Swinkels, Dorine W: 115 articles (02/2024 - 11/2004)
4.	Weiss, Günter: 94 articles (04/2024 - 01/2000)
5.	Muckenthaler, Martina U: 92 articles (04/2024 - 04/2004)
6.	Richardson, Des R: 91 articles (11/2022 - 01/2002)
7.	Zimmermann, Michael B: 86 articles (02/2024 - 01/2002)
8.	Bush, Ashley I: 82 articles (08/2023 - 11/2002)
9.	Georgieff, Michael K: 81 articles (02/2024 - 09/2002)
10.	Connor, James R: 79 articles (03/2024 - 03/2002)

Related Diseases

1.	Anemia 01/01/2019 - "The objectives of the symposium were to stress the high prevalence and the consequences of pre-operative anemia, illustrated with three clinical cases of women undergoing surgery, and to choose the best option for iron supplementation. " 04/15/2011 - "Most anemias were asymptomatic and improved with iron/multivitamin supplementation and cessation of ZDV exposure. " 05/01/2004 - "The regimen with iron administered daily is still the best option for treating anemia. " 02/15/2003 - "The combination of IPT and iron supplementation was most effective in the treatment of mild anemia. " 03/15/2024 - "The development of a safe and effective iron supplement is important for the treatment of iron-deficient anemia. "
2.	Iron Deficiencies 05/23/2018 - "Altogether, this study indicates that these synthetic FG-iron nanocomposites might be developed as novel iron supplements for iron deficiency, in which FG-FeCl3 is considered as the best option." 01/30/2023 - "Oral iron supplementation is the most widely used and cost-effective treatment for iron deficiency and IDA. " 10/31/2022 - "Our results indicate that the combined introduction of OsHRZ knockdown and OsIRT1 promoter-Refre1/372 is highly effective in further improving the iron deficiency tolerance without compromising the iron accumulation of the OsHRZ knockdown effects." 01/01/2022 - "For the detection of iron depletion (IDA or ACD/IDA) in anemic RA patients, sTfR is superior to SP of iron deficiency only in highly inflammatory states." 01/01/2022 - "Nevertheless, in the meantime, focusing on iron supplementation in high-risk mothers with emphasis on compliance, seems to be the best option, in view of the high prevalence of iron deficiency found in this review."
3.	Iron Overload 12/05/2014 - "Several studies have shown that targeting iron absorption could be beneficial in reducing or preventing iron overload in these 2 disorders, with promising preclinical data. " 01/04/2024 - "Notably, RosA exhibited a comparable iron chelation effect, and RosA-LIP demonstrated superior efficacy in mitigating liver damage induced by excessive iron overload. " 02/01/2019 - "Iron overload pathophysiology has benefited from significant advances in the knowledge of iron metabolism and in molecular genetics. " 06/01/2015 - "Conclusion DFX significantly improved iron metabolism in HD patients with iron overload and had an acceptable frequency of adverse effects. " 02/01/2014 - "Primary endpoint was regarded as significant improvement in the severity of liver and cardiac iron overload in severe and moderate cases, in addition to improvement or maintenance of the grade of severity in patients with mild iron overload or normal iron accumulation. "
4.	Iron-Deficiency Anemia (Anemia, Iron Deficiency) 01/01/2005 - "The prevalence of iron deficiency anemia (IDA) during the first year of life has been dramatically reduced in developed countries, mainly due to the increase in breastfeeding and the use of iron-fortified feeding formulae. " 03/01/2011 - "A previous study among schoolchildren supplemented with iron-fortified rice showed a significant reduction in the rate of iron-deficiency anemia from 100% to 33%. " 01/01/2020 - "Whether this dosing schedule is also beneficial in women with iron-deficiency anemia (IDA) given high-dose iron supplements is uncertain. " 09/01/2007 - "Because biscuits are a popular snack item and are consumed frequently by the younger population, fortification of biscuits with iron can be beneficial in preventing iron-deficiency anemia, which is widely prevalent in developing countries. " 10/01/2004 - "Iron deficiency anemia (IDA) is a significant public health challenge in resource-poor settings, despite strong evidence for efficacy of iron supplementation. "
5.	Neoplasms (Cancer) 12/01/2023 - "Targeting cell ferroptosis has shown remarkable efficacy against apoptosis-resistant tumors due to their elevated iron metabolism and oxidative stress levels. " 04/01/2024 - "To impede such metabolic compensation, we used a low iron diet together with autophagy inhibition and demonstrated a significant improvement of tumor response in syngeneic PDAC models.Abbreviations" 01/01/2020 - "In parallel, iron application inhibited the activation, expansion and survival of cytotoxic CD8+ T cells and of CD4+ T helper cells type 1 and significantly reduced the efficacy of the investigated anti-cancer treatments. " 07/01/2015 - "Here, we found a significant reduction of FPN levels in prostate tumors relative to adjacent tissues, and demonstrated a crucial role of FPN in tumor growth through controlling tumor iron concentration. " 03/15/2013 - "7T MR images obtained at 16 hours posttreatment revealed a significant reduction in signal indicating the presence of iron-loaded NK-92 cells at the tumor site. "

Related Drugs and Biologics

1.	Chelating Agents
2.	Ferritins (Ferritin)
3.	Hemoglobins (Hemoglobin)
4.	Deferoxamine (Desferal)
5.	Erythropoietin
6.	Hepcidins
7.	Deferasirox
8.	Deferiprone
9.	Antioxidants
10.	Saccharated Ferric Oxide (Venofer)

Related Therapies and Procedures

1.	Therapeutics
2.	Chelation Therapy (Therapy, Chelation)
3.	Renal Dialysis (Hemodialysis)
4.	Blood Transfusion (Blood Transfusions)
5.	Drug Therapy (Chemotherapy)