Pyroptosis in inflammation-related respiratory disease.

Abstract

Pyroptosis is commonly induced by the gasdermin (GSDM) family and is accompanied by the release of inflammatory cytokines such as IL-1β and IL-18. Recently, increasing evidence suggests that pyroptosis plays a role in respiratory diseases. This review aimed to summarize the roles and mechanisms of pyroptosis in inflammation-related respiratory diseases. There are several pathways involved in pyroptosis, such as the canonical inflammasome-induced pathway, non-canonical inflammasome-induced pathway, caspase-1/3/6/7/GSDMB pathway, caspase-8/GSDMC pathway, caspase-8/GSDMD pathway, and caspase-3/GSEME pathway. Pyroptosis may be involved in asthma, chronic obstructive pulmonary disease (COPD), lung cancer, acute lung injury (ALI), silicosis, pulmonary hypertension (PH), and tuberculosis (TB), in which the NLRP3 inflammasome-induced pathway is mostly highlighted. Pyroptosis contributes to the deterioration of asthma, COPD, ALI, silicosis, and PH. In addition, pyroptosis has dual effects on lung cancer and TB. Additionally, whether pyroptosis participates in cystic fibrosis (CF) and sarcoidosis or not is largely unknown, though the activation of NLRP3 inflammasome is found in CF and sarcoidosis. In conclusion, pyroptosis may play a role in inflammation-related respiratory diseases, providing new therapeutic targets.

• Authors: Yuanyu Feng, Min Li, Xiaoting Yangzhong, Xifeng Zhang, Anju Zu, Yunjiao Hou, Lin Li, Shibo Sun
• Journal: Journal of physiology and biochemistry (J Physiol Biochem) Vol. 78 Issue 4 Pg. 721-737 (Nov 2022) ISSN: 1877-8755 [Electronic] Spain
• PMID: 35819638 (Publication Type: Journal Article, Review)
• Copyright: © 2022. The Author(s).

Chemical References

• Inflammasomes
• NLR Family, Pyrin Domain-Containing 3 Protein
• Caspase 8
• GSDMC protein, human
• DNA-Binding Proteins
• Biomarkers, Tumor

Topics

• Humans
• Pyroptosis
• Inflammasomes (metabolism)
• NLR Family, Pyrin Domain-Containing 3 Protein (metabolism)
• Caspase 8 (metabolism, pharmacology)
• Acute Lung Injury
• Inflammation
• Lung Neoplasms
• Silicosis
• Pulmonary Disease, Chronic Obstructive
• Asthma
• Sarcoidosis
• DNA-Binding Proteins (metabolism, pharmacology)
• Biomarkers, Tumor