Silicosis

01/01/2018 - "The better understanding of early stage of silica-induced inflammatory process may help to develop earlier diagnosis of silicosis."
03/01/1993 - "The median (range) rate of clearance of 99mTc-DTPA in smokers with silicosis was 4.1 (1.9-12.7) %/minute, which was higher than the rates in non-smoking patients with silicosis of 2.2 (1.1-6.6) %/minute and in smokers without exposure to silica dust of 2.9 (1.6-4.5) %/minute. "
04/29/2005 - "Because no effective treatment for silicosis is available, effective control of exposure to crystalline silica in the workplace is crucial."
01/01/2022 - "The SNPs of 155 silicosis cases and 141 healthy silica-exposed controls were screened by genome-wide association study (GWAS), and the candidate SNPs of 194 silicosis cases and 235 healthy silica-exposed controls were validated by genotyping using the improved Mutiligase Detection Reaction (iMLDR) system. "
01/01/2019 - "Targeting Mechanics-Induced Fibroblast Activation through CD44-RhoA-YAP Pathway Ameliorates Crystalline Silica-Induced Silicosis."

09/01/1989 - "The genotoxicity of tetrandrine, a drug potentially useful for the treatment of silicosis, was studied using the micronucleus and the sister-chromatid exchange (SCE) assay systems. "
08/11/2023 - "The present study employed network pharmacology and molecular docking to determine the mechanism of action and the key active components of BYHWD of Tetrandrine in combination with BYHWD for silicosis. "
05/01/2022 - "Here, in this study, we established silicosis mouse models to investigate the effectiveness of tetrandrine of early and late therapeutic administration. "
12/01/1982 - "Studies of the chronic toxicity of tetrandrine in dogs: an inhibitor of silicosis."
08/11/2023 - "The potential targets for the treatment of silicosis using a combination of Tetrandrine and BYHWD were identified by considering the overlapping targets between compound drugs and silicosis. "

08/01/1992 - "[Pulmonary clearance of 99mTC-DTPA aerosol in patients with silicosis]."
09/01/1968 - "[On the efficacy of treating silicosis with alkaline aerosols and electroaerosols]."
01/01/2017 - "The objective of this study is the prediction and comparison of airway deposition patterns of an industrial aerosol in healthy workers and workers suffering from silicosis. "
01/01/2017 - "Indeed, workers suffering from silicosis receive significantly higher Ac doses than healthy workers exposed to the same aerosol. "
01/01/1992 - "Paxirasol aerosol applied in daily 3 x 5 puff doses in the treatment of silicosis patients is found to be a well tolerated drug form. "

11/01/2020 - "Identification of novel biomarkers for silicosis could be helpful for disease diagnosis and pathophysiological mechanism exploration. "
08/01/2023 - "Exploratory study on noninvasive biomarker of silicosis in exhaled breath by solid-phase microextraction-gas chromatography-mass spectrometry analysis."
03/01/2023 - "The present study aimed to investigate the sensitivity and specificity of combined detection of biomarkers in early auxiliary diagnosis of silicosis, the risk factors of silicosis were also studied. "
01/01/2023 - "Study aimed to investigate inflammatory, hematological, and biochemical parameters as additional biomarkers for diagnosing or monitoring silicosis. "
01/01/2021 - "The objetive of this study was to determine the clinical significance of specific biomarkers, to estimate their association with the development, severity and/or progression of silicosis, and identify determinants of this evolution. "

04/01/2022 - "However, whether and how pirfenidone is effective against silicosis remains unknown. "
04/01/2022 - "Here, we evaluated the efficacy of pirfenidone in the treatment of early and advanced silicosis in an experimental mouse model and explored its potential pharmacological mechanisms. "
04/01/2022 - "Moreover, we observed that both 100 and 200 mg/kg pirfenidone can effectively treat early-stage silicosis, while 400 mg/kg was recommended for advanced silicosis. "
01/01/2018 - "On basis of this mechanism, pirfenidone might be a potential drug for the treatment of silicosis."
10/01/2010 - "to investigate whether pirfenidone (PFD) presents the antifibrotic effect in silicosis of rats. "

01/01/2019 - "Studies investigating association between tumor necrosis factor (TNF) gene polymorphisms and silicosis susceptibility report conflicting results. "
02/01/2014 - "The study concluded, the genetic variation on TNF-alpha gene locus -308 was a risk factor of silicosis in Indonesia cement factory. "
01/01/2019 - "Tumor necrosis factor gene polymorphisms are associated with silicosis: a systemic review and meta-analysis."
02/01/2014 - "The result showed proportion of the genetic variation on TNF-alpha on Locus -308 in Indonesia was significantly (p = 0.02) higher on silicosis (13.45%) than nonsilicosis (5.45%) but lower than silicosis in Africa and US miners, since susceptibility loci might vary in different ethnic groups. "
01/01/2013 - "Tumor necrosis factor-α (TNF-α) 308 G/A gene polymorphism has been reported to be associated with susceptibility to silicosis. "

09/23/2023 - "Our previous studies have highlighted that human umbilical cord mesenchymal stem cell-derived extracellular vesicles (hucMSC-EVs) hold promise in mitigating silicosis and the significant role played by microRNAs (miRNAs) in this process. "
01/01/2021 - "The present study aimed to examine the anti‑fibrotic effects and specific mechanism of action of microRNA (miR)‑29c in pulmonary silicosis using animal and cell models. "
01/01/2012 - "The aim of the present study is to investigate the altered miRNAs expression profile in rats with experimental silicosis. "
05/09/2024 - "However, the regulation and mechanism of miRNAs on lymphangiogenesis in silicosis remain unclear. "
11/15/2023 - "Our previous research found that serum exosomal miR125a-5p was increased in silicosis patients by miRNAs high-throughput sequencing. "

06/01/1993 - "In the present study, we evaluated the efficacy of aluminium inhalation in altering the silicosis process after disease was recognized by standard chest radiography. "
11/01/1995 - "In a recent study, it was noted that aluminium inhalation failed to alter the silicosis process after disease was recognised by standard chest radiography in the first year after monthly treatment. "
09/01/1955 - "Prophylaxis and treatment of experimental silicosis by means of aluminum; an experimental study."
12/01/2013 - "No protective effect against silicosis was observed from aluminium dust inhalation. "
12/01/2013 - "During the 1950s and 1960s, aluminium dust inhalation was used as a potential prophylaxis against silicosis in underground miners, including in Australia. "

09/01/2017 - "The frequency of the IL-17F (+7488A/G) genotype was significantly greater in patients with accelerated silicosis (odds ratio = 10.13 95%; confidence interval = 1.2-81.5; p = 0.008). "
09/01/2017 - "The aim of the present study was to analyze the association between SNPs at IL-17A (-832A/G) and IL-17F (+7488A/G) and susceptibility to accelerated silicosis in the Iranian Kurdish population. "
06/20/2019 - "Conclusion: No relationship was found between IL-17A gene polymorphisms at rs4711998 and silicosis. "
09/01/2017 - "The IL-17F (+7488 G) allele was associated with an increased risk of accelerated silicosis, but in the case of the IL-17A (-832A/G) polymorphism, a significant association was not observed."
09/01/2017 - "The IL-17F (+7488A/G) genotype revealed a significantly increased risk of accelerated silicosis ( p < 0.05). "

01/01/1981 - "This new entity, sarcoido-silicosis, follows its own course, insensitive to corticosteroids. "
08/04/1961 - "[The treatment of "acute" silicosis with corticosteroids]."
02/01/1992 - "Acute silicosis responding to corticosteroid therapy."
08/01/1963 - "[INHALATION OF CORTICOSTEROIDS IN SILICOSIS THERAPY]."
02/01/1992 - "We report an unusual case of acute silicosis in which improvement in clinical status, chest x-ray film findings and pulmonary function occurred following therapy with corticosteroids. "

01/01/2012 - "The results further suggest that therapies targeting myofibroblast differentiation may have therapeutic efficacy in treatment of silicosis of the lung."
06/01/2012 - "Although the majority of patients with silicosis are in therapy routinely, the patients' quality of life has been impaired because silicosis cannot be cured. "
06/01/2021 - "In conclusion, the present study illuminates the role of ER stress-related IRE1α-TXNDC5 signaling in fibroblast activation and its effects on CS-induced pulmonary fibrogenesis, which may provide novel targets for silicosis therapy."
09/01/2014 - "This study describes a potentially important inflammatory mechanism of silicosis that may bring about novel therapies for this inflammatory and fibrotic disease. "
09/01/2013 - "The present study provides an experimental basis for cellular therapy in silicosis."

12/01/2016 - "Conclusion: Lung transplantation is beneficial for patients with phase Ⅲ silicosis, long-term survival is probable."
05/25/2009 - "In the present work we evaluated the lung transplant database (May 1986-July 2007) at the University of Pittsburgh to study the efficacy of lung transplantation in patients with silicosis (n = 11). "
01/01/2021 - "This study aimed to review the risk factors for silicosis together with survival analysis and a perspective for lung transplantation with data from a single center. "
11/01/2017 - "In this study, we aimed to determine the impact of lung transplantation (LTx) on pulmonary function tests (PFTs) and survival among patients with end-stage silicosis. "
03/01/2017 - "A total of 17 lung transplantations were performed for silicosis among 342 lung transplantations (4.9%) during the study period. "

07/01/2001 - "From among a total of 260 patients with silicosis contracted from granite work, 141 with available serial chest x ray films of acceptable quality taken over a period of 2 to 17 (mean 7.5) years, were selected for study. "
06/01/1996 - "In patients with stable shadows on chest X-ray films due to large opacities of silicosis, the delayed ratio was the same as or lower than the early ratio. "
05/01/1980 - "X-ray film of the thorax and scintigram pointed to a stronger and earlier silicosis affection of the right lung than of the left one."
02/06/1954 - "Comparison of different types of x-ray films for case finding and diagnosis of silicosis."
01/01/1985 - "A study was conducted to test the feasibility of training lay persons to screen chest x-ray films for professional readers in an industrial screening program and to use the International Labor Office classification of the pneumoconioses for silicosis. "

01/01/1954 - "[Essay with tissue therapy in early silicosis; consecutive development of tuberculosis]."
01/01/2014 - "Therefore, BMMC therapy in the late stages of experimental silicosis improved lung function by diminishing fibrosis but inflammatory cells persisted, which could be related to expansion of T regulatory cells, responsible for the beneficial effects of cell therapy."
01/01/2023 - "This review addresses the definition of mesenchymal stromal cells (MSCs), their properties, mechanisms of action, as well as preclinical and clinical studies that have used cell therapy in chronic lung diseases such as asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, pulmonary arterial hypertension, and silicosis. "

12/01/1997 - "The efficacy of beclomethasone dipropionate (CAS 5534-09-8, BDP, beclomethasone) inhalation therapy over the course of 12 months were evaluated in 42 patients with established chronic silicosis. "
12/01/1997 - "These results suggest that corticosteroid inhalation therapy is helpful in the management of chronic silicosis, especially in patients with sputum eosinophilia. "
05/23/1965 - "[STUDY OF THE EFFECT OF TRYPSIN AEROSOL INHALATION THERAPY ON SILICOSIS]."