Abstract |
Cancer patients often suffer from severe pain related to bone metastasis. We encountered a patient in whom the addition of topical non-steroidal anti-inflammatory drugs ( NSAIDs) for persistent pain related to bone metastasis during therapy with opioids and oral NSAIDs reduced pain, improving activities of daily living ( ADL). Fentanyl patches, celecoxib, denosumab, and topical NSAIDs ( loxoprofen tape, felbinac) were administered to a 72-year-old patient with gastric cancer and pain related to bone metastasis. Pain control was favorable, with a numerical rating scale (NRS) score of 2 and Japanese version Support Team Assessment Schedule ( STAS-J) score of 1. Intervention by pharmacists for the use of topical NSAIDs decreased both the NRS and STAS-J scores to zero, improving ADL. The results suggest that topical NSAIDs relieve bone- metastasis-related pain, improving ADL. When bone- metastasis-related pain is localized, the prescription of topical NSAIDs should be considered, and positive intervention by pharmacists regarding their usage should be promoted.
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Authors | Kazutoshi Terayama, Mayumi Hamana, Masao Tsuchiya, Tamaki Watanabe, Hiromi Enomoto, Nobuhiro Yasuno, Kunihisa Miura, Kazuki Ohta, Shigekazu Watanabe |
Journal | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
(Yakugaku Zasshi)
Vol. 140
Issue 8
Pg. 1081-1085
( 2020)
ISSN: 1347-5231 [Electronic] Japan |
PMID | 32741866
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Analgesics, Opioid
- Anti-Inflammatory Agents, Non-Steroidal
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Topics |
- Activities of Daily Living
- Administration, Oral
- Administration, Topical
- Aged
- Analgesics, Opioid
(administration & dosage)
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage)
- Bone Neoplasms
(complications, physiopathology, secondary)
- Cancer Pain
(drug therapy, etiology)
- Drug Therapy, Combination
- Humans
- Male
- Stomach Neoplasms
(pathology)
- Treatment Outcome
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