Denosumab

A humanized monoclonal antibody and an inhibitor of the RANK LIGAND, which regulates OSTEOCLAST differentiation and bone remodeling. It is used as a BONE DENSITY CONSERVATION AGENT in the treatment of OSTEOPOROSIS.

Also Known As:

Networked: 2769 relevant articles (350 outcomes, 635 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Nakamura, Yukio: 32 articles (03/2022 - 12/2015)
2.	Lewiecki, E Michael: 32 articles (04/2020 - 02/2006)
3.	Suzuki, Takako: 28 articles (03/2022 - 01/2017)
4.	Libanati, Cesar: 27 articles (01/2022 - 07/2008)
5.	McClung, Michael R: 25 articles (07/2021 - 02/2006)
6.	Body, Jean-Jacques: 25 articles (06/2021 - 02/2006)
7.	Brown, Jacques P: 24 articles (01/2022 - 01/2009)
8.	Kato, Hiroyuki: 24 articles (01/2020 - 12/2015)
9.	Saad, Fred: 23 articles (04/2022 - 08/2009)
10.	Wagman, Rachel B: 22 articles (01/2020 - 01/2009)

Related Diseases

1.	Osteoporosis 11/01/2021 - "In conclusion, denosumab was highly effective in this case of primary pediatric osteoporosis, with remarkable clinical and radiological response. " 04/19/2017 - "Denosumab is a very effective treatment of osteoporosis, easy to use and very well tolerated. " 06/01/2023 - "In postmenopausal women with osteoporosis, up to 10 years of denosumab significantly and continuously improved bone microarchitecture assessed by TBSTT, independently of BMD, and shifted more patients to lower fracture-risk categories." 06/01/2023 - "In postmenopausal women with osteoporosis, up to 10 years of denosumab treatment significantly and continuously improved bone microarchitecture assessed by tissue thickness-adjusted trabecular bone score, independently of bone mineral density. " 12/01/2022 - "In postmenopausal women with osteoporosis, denosumab significantly improved bone microstructure assessed by TBSTT over 3 years. "
2.	Neoplasm Metastasis (Metastasis) 11/01/2017 - "This meta-analysis indicates that denosumab is superior to ZA in delaying SREs for patients with bone metastases. " 08/01/2013 - "Denosumab offers superior efficacy compared with ZA in patients with solid tumours and bone metastases. " 08/01/2013 - "Denosumab is superior to ZA in preventing complications for patients with bone metastases. " 07/01/2012 - "Denosumab has been shown to be effective in prolonging time to first SRE in clinical settings, however, critical questions remain on its ability to affect bone metastases in mCRPC. " 01/01/2019 - "Thus inhibition of the RANKL-RANK pathway is a promising treatment for bone metastasis, and a human monoclonal anti-RANKL antibody, denosumab, has been used in the clinic. "
3.	Neoplasms (Cancer) 05/15/2017 - "The tumor responded to subcutaneously administered denosumab with marked decrease in size and relief of symptoms. " 07/01/2014 - "The authors describe the case of 22-year-old female patient, harboring a GCT involving the C2 vertebral body and odontoid process, who was treated in monotherapy with denosumab, resulting in complete long-term clinical and radiographic tumor remission. " 02/01/2023 - "During the last few years, there has been a significant evolution in the diagnosis and management of GCTB, including discoveries related to the underlying pathogenesis (RANK/RANK/OPG pathway), with treatment-related implications in the form of denosumab (approved inhibitor for targeting RANKL), leading to improved surgical resections, especially in cases of recurrent, large and borderline resectable tumors. " 03/01/2017 - "However, no significant benefits on cancer-specific and overall survival were observed and denosumab was not approved by the US FDA and EMA in this context. " 01/01/2017 - "Pediatric data is limited; however, evidence suggests denosumab may be beneficial in decreasing bone turnover, increasing bone density, and preventing growth of certain skeletal neoplasms in children. "
4.	Pain (Aches) 11/01/2022 - "On literature review, although some serious side effects were noted, patients experienced a decline in bone turnover markers, and most reported improvement in bone pain with denosumab. " 10/01/2019 - "A significant reduction in pain under denosumab treatment was reported in seven studies and additional improvement in function and mobility was reported by several authors. " 01/22/2021 - "Signs associated with potential misdiagnoses of GCTB included poor mineralization with denosumab treatment, rapid relapse in pain, or a failure of the typical dramatic improvement in pain normally observed with denosumab. " 09/01/2016 - "Denosumab appears to be effective in reducing bone turnover and bone pain in adult patients with active MFD." 10/01/2015 - "Denosumab is effective in reducing the risk of new vertebral fractures, but its effectiveness on pain relief and improvement of the quality of life in patients with spine fractures are not well known. "
5.	Postmenopausal Osteoporosis 10/01/2020 - "Denosumab is a highly effective treatment for postmenopausal osteoporosis, significantly improving BMD and reducing risk of fracture. " 09/01/2022 - "From the perspective of Malaysian health care providers, denosumab was cost-effective in the treatment of postmenopausal osteoporosis, with an optimal outcome starting at age 60 years. " 05/01/2020 - "Denosumab is a potent antiresorptive drug leading to significant reduction in the risk of vertebral and non-vertebral fractures in postmenopausal osteoporosis. " 01/01/2012 - "Denosumab treatment is associated with a rapid, sustained, and reversible reduction in bone turnover markers, a continuous marked increase in bone mineral density at all sites, and a marked decrease in the risk of vertebral, hip, and nonvertebral fractures in women with postmenopausal osteoporosis. " 02/01/2009 - "In studies conducted so far, denosumab is an efficacious and well-tolerated treatment for postmenopausal osteoporosis. "

Related Drugs and Biologics

1.	Diphosphonates (Bisphosphonates)
2.	Zoledronic Acid (Zometa)
3.	Monoclonal Antibodies
4.	Teriparatide (Parathar)
5.	RANK Ligand
6.	Ligands
7.	Alendronate (Alendronate Sodium)
8.	Glucocorticoids
9.	romosozumab
10.	Calcium

Related Therapies and Procedures

1.	Therapeutics
2.	Castration
3.	Fracture Fixation
4.	Renal Dialysis (Hemodialysis)
5.	Injections