Celecoxib (Celebrex)

A pyrazole derivative and selective CYCLOOXYGENASE 2 INHIBITOR that is used to treat symptoms associated with RHEUMATOID ARTHRITIS; OSTEOARTHRITIS and JUVENILE ARTHRITIS, as well as the management of ACUTE PAIN.

Also Known As:

Networked: 3870 relevant articles (554 outcomes, 1291 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Chen, Ching-Shih: 23 articles (04/2019 - 04/2002)
2.	Schönthal, Axel H: 21 articles (12/2012 - 01/2004)
3.	Abdellatif, Khaled R A: 18 articles (01/2022 - 11/2014)
4.	Bertagnolli, Monica M: 18 articles (01/2018 - 10/2004)
5.	Arber, Nadir: 17 articles (08/2013 - 01/2004)
6.	Reddy, Bandaru S: 17 articles (02/2009 - 01/2002)
7.	Rao, Chinthalapally V: 15 articles (01/2022 - 01/2002)
8.	Tang, Cheng-Wei: 13 articles (07/2020 - 12/2004)
9.	Sanyal, Sankar Nath: 13 articles (01/2016 - 03/2008)
10.	Petasis, Nicos A: 13 articles (12/2012 - 05/2005)

Related Diseases

1.	Pain (Aches) 02/01/2012 - "The reduction in pain intensity from baseline to 2 hours after the additional dose of study medication was also significantly greater in the celecoxib 200 mg group than in the placebo group (P < 0.0001). " 01/01/2001 - "The results of this study confirm the clinically relevant antiinflammatory effect of celecoxib at a 200-mg daily dosage, with significant improvement of both pain and function in patients with AS." 01/01/2021 - "Early administration of celecoxib after TKA was associated with significantly reduced early VAS pain scores and improved sleep quality and active knee flexion angles. " 01/01/2020 - "Both Verbascox® and celecoxib reduced pain, improved functional capacity, and lowered serum SP levels at 2 weeks compared with baseline, without significant inter-arm differences. " 09/01/2017 - "In the intention-to-treat (ITT) population, pain reduction in VAS at day 182 in the CS group (-42.6 mm) and in celecoxib group (-39.5 mm) was significantly greater than the placebo group (-33.3 mm) (p=0.001 for CS and p=0.009 for celecoxib), while no difference observed between CS and celecoxib. "
2.	Neoplasms (Cancer) 05/01/2004 - "One striking observation in an additional study was that celecoxib feeding to mice with established tumors (16 weeks of age) significantly improved their overall survival (P = 0.014), compared with AIN 76A-fed group. " 08/01/2014 - "Celecoxib is beneficial in the treatment of advanced cancers but with increased risk of cardiovascular events. " 05/01/2005 - "Treatment of the COX-2 transgenic mice in the FVB/N strain with celecoxib (1600 ppm), a COX-2 selective inhibitor, resulted significant reduction in tumor size and multiplicity when compared to transgenic mice fed with control chow. " 12/10/2009 - "Despite the associated cardiovascular toxicity risk, celecoxib has been found to be effective in reducing cancer risk in animal and human studies. " 01/01/2018 - "Celecoxib augmented the therapeutic efficacy while modulated cancer stemness and antitumor immunity. "
3.	Osteoarthritis 11/01/1999 - "Celecoxib treatment led to significant improvement in the signs and symptoms of osteoarthritis as determined by all efficacy measures. " 01/01/2014 - "Celecoxib is an effective treatment for osteoarthritis (OA). " 12/01/2017 - "Comparing the Safety and Efficacy of Celecoxib for the Treatment of Osteoarthritis in Asian and non-Asian Populations: An Analysis of Data from Two Randomized, Double-blind, Placebo-controlled, Active-comparator Trials." 04/01/2008 - "This study shows that the quality of life improved in patients with osteoarthritis after 4 weeks of celecoxib treatment, in the physical as well psychological and social domains. " 01/01/2020 - "A comparative study of the efficacy of NAXOZOL compared to celecoxib in patients with osteoarthritis."
4.	Postoperative Pain 10/01/2019 - "Furthermore, when compared to the other groups, patients in the celecoxib group showed a significant reduction in postoperative pain scores at 6h (P<0.001), 12h (P=0.011), and 24h (P=0.041) after surgery. " 03/01/2008 - "Celecoxib (400 mg p.o.) administered on the day of surgery and for 3 days postoperatively is effective in improving postoperative pain management, as well as the speed and quality of recovery after major plastic surgery. " 01/01/2023 - "This study aims to compare the efficacy of preemptive periarticular multimodal drug injection versus placebo and oral celecoxib on postoperative pain control after TKA. " 06/01/2017 - "Efficacy of Celecoxib for Early Postoperative Pain Management in Hip Arthroscopy: A Prospective Randomized Placebo-Controlled Study." 01/01/2017 - "The aim of this study was to evaluate the safety of administering celecoxib to manage postoperative pain after liver surgery. "
5.	Inflammation (Inflammations) 06/01/2017 - "The results showed that a rat model of STZ-induced diabetes was successfully established and that celecoxib treatment significantly improved the associated nephropathy and inflammation. " 01/01/2020 - "We further assessed whether colon microbiota modulates anti-inflammatory efficacy of celecoxib using a simplified inflammation model, and a novel in vitro simulation of the enterohepatic metabolism. " 02/10/2015 - "Importantly, the FDA-approved drug celecoxib re-establishes the AKT/miR-199a-5p/CAV1 axis in CF macrophages, and ameliorates lung hyper-inflammation in Cftr-deficient mice. " 11/15/2020 - "Nano wet milled celecoxib extended release microparticles for local management of chronic inflammation." 01/01/2017 - "Celecoxib-treated HPV16+/- animals also showed reduced incidence of epidermal dysplasia and reduced inflammation, compared to untreated mice. "

Related Drugs and Biologics

1.	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)
2.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
3.	rofecoxib (Vioxx)
4.	Naproxen (Naprosyn)
5.	Analgesics (Analgesic Drugs)
6.	Acetaminophen (Paracetamol)
7.	Cyclooxygenase 2 (Cyclooxygenase-2)
8.	Diclofenac (SR 38)
9.	Ibuprofen (Motrin)
10.	Aspirin (Acetylsalicylic Acid)

Related Therapies and Procedures

1.	Therapeutics
2.	Chemoprevention
3.	Analgesia
4.	Drug Therapy (Chemotherapy)
5.	Oral Administration