Inflammatory Bowel Disease in Juvenile Idiopathic Arthritis Patients Treated with Biologics.

Abstract

OBJECTIVE:

Evolving inflammatory bowel disease (IBD) is a matter of interest in patients with juvenile idiopathic arthritis (JIA) and might be associated with JIA therapy.

METHODS:

Data from the German biologics registry (Biologika in der Kinderrheumatologie; BiKeR) from 2001 to 2013 were analyzed.

RESULTS:

There were 3071 patients with 8389 patient-years (PY) of observation followed. IBD was diagnosed in 11 patients, 8 with Crohn disease and 3 with ulcerative colitis. IBD incidence in patients with JIA was 1.31/1000 PY and higher than published IBD incidences in pediatric populations. Compared with the total BiKeR cohort, patients with IBD more commonly had enthesitis-related arthritis, extended oligoarthritis, psoriatic arthritis, and also rheumatoid factor (RF)-negative polyarthritis. No IBD occurred in patients with systemic JIA or RF-positive polyarthritis. In patients treated with methotrexate (MTX), the IBD incidence was significantly lower compared with patients not treated with MTX. Etanercept (ETN) monotherapy, but not the combination of ETN and MTX, was associated with an increased incidence of IBD.

CONCLUSION:

Incidence of IBD in patients with JIA is higher than in the population. MTX turned out to be protective, even in combination with ETN.

• Authors: Deborah Barthel, Gerd Ganser, Rolf-Michael Kuester, Nils Onken, Kirsten Minden, Hermann Josef Girschick, Anton Hospach, Gerd Horneff
• Journal: The Journal of rheumatology (J Rheumatol) Vol. 42 Issue 11 Pg. 2160-5 (Nov 2015) ISSN: 0315-162X [Print] Canada
• PMID: 26373564 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Biological Products
• Etanercept
• Methotrexate

Topics

• Adolescent
• Age Distribution
• Arthritis, Juvenile (diagnosis, drug therapy, epidemiology)
• Biological Products (adverse effects, therapeutic use)
• Child
• Child, Preschool
• Cohort Studies
• Comorbidity
• Etanercept (adverse effects, therapeutic use)
• Female
• Germany
• Humans
• Incidence
• Inflammatory Bowel Diseases (chemically induced, epidemiology, physiopathology)
• Male
• Methotrexate (adverse effects, therapeutic use)
• Prognosis
• Prospective Studies
• Registries
• Risk Assessment
• Severity of Illness Index
• Sex Distribution