Abstract | PURPOSE: This prospective, blinded study was designed to assess intraperitoneal cytokine productions and their relationship to clinical presentations and systemic inflammatory markers in patients with inflammatory bowel disease. METHODS: RESULTS: The median intraperitoneal cytokine ( interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha) levels were significantly higher in patients with inflammatory bowel disease than in patients with colorectal cancer and acute appendicitis. In patients with inflammatory bowel disease, intraperitoneal cytokine levels were significantly higher in patients with intraperitoneal sepsis ( abscess/ fistula) than in patients without intraperitoneal sepsis at laparotomy. Intraperitoneal cytokine levels did not correlate with type of disease ( ulcerative colitis/ Crohn's disease), age, gender, duration of disease before surgery, preoperative medical treatment, and the extent or site of disease. There were no significant correlations between intraperitoneal cytokine levels and the following systemic inflammatory markers: plasma cytokine levels, white blood cell count, platelet count, erythrocyte sedimentation rate, and C-reactive protein levels. Postoperative intraperitoneal septic complications ( anastomotic leak/ abscess/ enterocutaneous fistula) more frequently occurred in patients with higher intraperitoneal cytokine levels. CONCLUSIONS: Intraperitoneal cytokine productions were greatly elevated in patients with inflammatory bowel disease, and their levels correlated with the presence of intraperitoneal sepsis at laparotomy and development of postoperative intraperitoneal septic complications. Intraperitoneal cytokine levels showed no correlations with systemic inflammatory markers.
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Authors | Takayuki Yamamoto, Satoru Umegae, Tatsushi Kitagawa, Koichi Matsumoto |
Journal | Diseases of the colon and rectum
(Dis Colon Rectum)
Vol. 48
Issue 5
Pg. 1005-15
(May 2005)
ISSN: 0012-3706 [Print] United States |
PMID | 15785898
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Interleukin-1
- Interleukin-6
- Tumor Necrosis Factor-alpha
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Topics |
- Adult
- Appendicitis
(metabolism, surgery)
- Chi-Square Distribution
- Colorectal Neoplasms
(metabolism, surgery)
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Inflammatory Bowel Diseases
(metabolism, surgery)
- Interleukin-1
(metabolism)
- Interleukin-6
(metabolism)
- Male
- Middle Aged
- Peritoneum
(metabolism)
- Peritonitis
(metabolism, surgery)
- Prospective Studies
- Regression Analysis
- Statistics, Nonparametric
- Tumor Necrosis Factor-alpha
(metabolism)
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