S100 Calcium Binding Protein beta Subunit

A calcium-binding protein that is 92 AA long, contains 2 EF-hand domains, and is concentrated mainly in GLIAL CELLS. Elevation of S100B levels in brain tissue correlates with a role in neurological disorders.

Also Known As:

NTP-S-100beta; Nerve Tissue Protein S 100, beta Subunit; Nerve Tissue Protein S 100b; Neural Protein S-100B; Neurotrophic Protein S100beta; Proteins, S-100b; S-100 Calcium-Binding Protein beta Subunit; S-100b Protein; S-100beta; S100beta Protein; NTP S 100beta; Neural Protein S 100B; Protein S-100B, Neural; Protein S100beta, Neurotrophic; Protein, S-100b; Protein, S100beta; Proteins, S 100b; S 100 Calcium Binding Protein beta Subunit; S 100b Protein; S 100beta; S-100B, Neural Protein; S-100b Proteins; S100beta, Neurotrophic Protein

Networked: 219 relevant articles (6 outcomes, 44 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Calcium-Binding Proteins: 1333
      - S100 Proteins: 3806
        S100 Calcium Binding Protein beta Subunit: 219
        human S100B protein
        mouse S100b protein
        rat S100b protein
  - Nerve Tissue Proteins: 2
    - S100 Proteins: 3806
      - S100 Calcium Binding Protein beta Subunit: 219
        human S100B protein
        mouse S100b protein
        rat S100b protein

Experts

1.	Korfias, S: 4 articles (02/2009 - 03/2003)
2.	Sakas, D E: 4 articles (02/2009 - 03/2003)
3.	Otto, Markus: 4 articles (01/2009 - 11/2002)
4.	Boviatsis, Efstathios: 4 articles (02/2007 - 08/2004)
5.	Korfias, Stefanos: 4 articles (02/2007 - 08/2004)
6.	Psachoulia, Christina: 4 articles (02/2007 - 08/2004)
7.	Sakas, Damianos E: 4 articles (02/2007 - 08/2004)
8.	Stranjalis, George: 4 articles (02/2007 - 08/2004)
9.	Vajtr, D: 3 articles (01/2012 - 07/2007)
10.	Stranjalis, G: 3 articles (02/2009 - 01/2006)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 01/01/2001 - "Although there is good evidence from several studies that protein S-100B serum measurement could serve as a valid marker for micro- and/or macrometastasis, the S-100B-LIAmat test has not been established as part of national and international recommendations for the care of melanoma patients. " 07/01/2007 - "S-100beta and melanoma-inhibitory activity (MIA) serum levels are elevated in metastatic cutaneous melanoma. " 01/01/2007 - "These results provide evidence of the clinical usefulness of serum S-100beta level determination in high-risk melanoma patients. " 09/01/2006 - "[Serum levels of S-100b protein after four years follow-up of patients with melanoma]." 05/01/2005 - "S-100beta and MIA in advanced melanoma in relation to prognostic factors."
2.	Brain Injuries (Brain Injury) 12/01/2000 - "This finding supports the results of previous studies suggesting the potential accuracy of S-100beta in the prediction of brain injury after cardiac surgery." 01/01/2010 - "The prognostic value of the temporal course of S100beta protein in post-acute severe brain injury: A prospective and observational study." 05/01/2005 - "Complement activation and cellular brain injury were assessed by measuring sC5b-9 and protein s100beta. " 07/24/1999 - "Interactions between S-100beta and bFGF may be relevant to the events related to neuronal maintenance and repair following brain injury." 06/01/2003 - "Serial measurement of serum S-100B protein in the initial 12 hours after cardiopulmonary bypass can be used to predict early postoperative brain injury."
3.	Neoplasms (Cancer) 02/01/2019 - "We found that S-100B protein and NSE serum concentrations were elevated in PNS patients without diagnosed malignancy, and S-100B additionally in patients with peripheral nervous system manifestation of PNS. " 01/01/1983 - "Distribution of S-100b protein in normal salivary glands and salivary gland tumors." 07/01/2007 - "OPN, S-100beta and MIA levels were measured by ELISA assays in 18 patients with metastatic UM and in 38 patients who were disease-free (DF) for at least 10 years after treatment of the primary tumor. " 02/01/2001 - "Serum S-100B protein was not a significant independent prognostic factor in clinical stage I, where tumor thickness showed the strongest relation to melanoma-specific survival, followed by ulceration and satellites. " 01/01/1983 - "Immuno-electron microscopically, S-100b protein was diffusely distributed in the cytoplasm of myoepithelial cells as well as of tumor cells of pleomorphic adenoma, being distributed especially on the membrane of endoplasmic reticulum and the outer nuclear membrane."
4.	Hypoxia (Hypoxemia) 08/01/2005 - "Acute hypoxia increases S100beta protein in association with blood flow redistribution away from peripheral circulations in fetal sheep." 08/01/2005 - "We investigated in fetal sheep during late gestation the effects of acute hypoxemia on fetal plasma S100beta protein concentrations and how these relate to fetal redistribution of blood flow and acid-base status. " 01/01/2017 - "Early-induced molecules driven by hypoxia, as chaperonins HSPs and ORP150, besides common markers for inflammatory responses, have predictive value in timing the onset of neonatal HII; on the other hand, clinical biomarkers for HII diagnosis, as CK-BB, LDH, S-100beta, and NSE, could be useful to predict outcomes." 04/01/2014 - "[The role of VEGF, HSP-70 and protein S-100B in the potentiation effect of the neuroprotective effect of hypercapnic hypoxia]." 04/01/2014 - "This suggests dominant effect hypercapnia, hypoxia compared in neuroprotection mechanisms related to protein S-100B, but not the protein VEGF, hypercapnia and potentiate the neuroprotective efficacy of hypoxia-related protein HSP-70."
5.	Schizophrenia (Dementia Praecox) 06/01/1999 - "Our findings indicate that patients with schizophrenia may suffer ongoing structural damage to cells of the central nervous system, and that the concentration of S-100b protein in plasma may help to identify clinical subgroups in schizophrenia." 01/01/2007 - "Plasma S-100B protein in Chinese patients with schizophrenia: comparison with healthy controls and effect of antipsychotics treatment."

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