Abstract | BACKGROUND: We used serial measurements of serum S-100B protein to evaluate the time course of serum S-100B protein concentration after cardiovascular surgery and to determine the clinical relevance of its concentration and cerebral damage. METHODS: We assessed neurologic function in 149 patients undergoing cardiovascular surgery with cardiopulmonary bypass. The patients were classified into three groups according to their early postoperative outcome: those without complications (group A), those having unconsciousness or convulsion or both but no hemiplegia (group B), and those having unconsciousness and hemiplegia either with or without convulsion (group C). Serum S-100B protein concentrations were measured with a commercially available immunoluminometric assay, Sangtec 100 LIA, at seven time-points: before cardiopulmonary bypass, at the end of cardiopulmonary bypass, and at 5, 12, 24, 48, and 72 hours after cardiopulmonary bypass. RESULTS: At 5 hours after cardiopulmonary bypass, the S-100B values in groups B and C were significantly higher than the value in group A. Although the S-100B level decreased in group C during the first 5 hours after cardiopulmonary bypass, it increased thereafter (12 through 24 hours) and continued at a high level until the final measurement at 72 hours. At 12 hours after cardiopulmonary bypass, S-100B was significantly higher in group C than in group B. This late increase in S-100B was associated with radiologically detected abnormalities and cerebral damage. CONCLUSIONS:
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Authors | Takayuki Ueno, Yoshihumi Iguro, Hiroyuki Yamamoto, Ryuzo Sakata, Yasuyuki Kakihana, Kazuo Nakamura |
Journal | The Annals of thoracic surgery
(Ann Thorac Surg)
Vol. 75
Issue 6
Pg. 1892-7; discussion 1897-8
(Jun 2003)
ISSN: 0003-4975 [Print] Netherlands |
PMID | 12822633
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Nerve Growth Factors
- S100 Calcium Binding Protein beta Subunit
- S100 Proteins
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Topics |
- Aged
- Biomarkers
(blood)
- Brain Damage, Chronic
(blood, diagnosis)
- Cardiopulmonary Bypass
(adverse effects)
- Cardiovascular Diseases
(blood, mortality, surgery)
- Comorbidity
- Female
- Hospital Mortality
- Humans
- Male
- Middle Aged
- Nerve Growth Factors
- Neurologic Examination
- Postoperative Complications
(blood, diagnosis, mortality)
- Predictive Value of Tests
- Reference Values
- Risk Factors
- S100 Calcium Binding Protein beta Subunit
- S100 Proteins
(blood)
- Survival Analysis
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