Cartilage Oligomeric Matrix Protein

Major component of chondrocyte EXTRACELLULAR MATRIX of various tissues including bone, tendon, ligament, SYNOVIUM and blood vessels. It binds MATRILIN PROTEINS and is associated with development of cartilage and bone.

Also Known As:

Networked: 463 relevant articles (5 outcomes, 57 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hecht, Jacqueline T: 17 articles (08/2021 - 03/2002)
2.	Briggs, Michael D: 11 articles (01/2015 - 05/2002)
3.	Posey, Karen L: 10 articles (08/2021 - 06/2004)
4.	Holmdahl, Rikard: 9 articles (01/2022 - 01/2002)
5.	Saxne, T: 9 articles (09/2017 - 08/2000)
6.	Alcorn, Joseph L: 9 articles (01/2017 - 04/2006)
7.	Saxne, Tore: 9 articles (10/2016 - 01/2003)
8.	Zaucke, Frank: 8 articles (12/2021 - 08/2002)
9.	Blom, Anna M: 8 articles (11/2021 - 12/2010)
10.	Kong, Wei: 7 articles (01/2021 - 06/2006)

Related Diseases

1.	Knee Osteoarthritis 01/01/2021 - "This study aimed to determine if changes in knee adduction moment (KAM) after 6 months of variable-stiffness shoe wear are associated with changes in symptoms or serum levels of cartilage oligomeric matrix protein (COMP) following a mechanical stimulus in subjects with medial knee osteoarthritis (OA). " 09/01/2017 - "This study aims (i) to compare synovial fluid and serum cartilage oligomeric matrix protein levels in patients with primary knee osteoarthritis and healthy controls, (ii) compare variations of synovial fluid and serum cartilage oligomeric matrix protein levels according to sex, Kellgren-Lawrence grades, and daytime sampling, and (iii) correlate the synovial fluid and serum cartilage oligomeric matrix protein levels with age, severity of disease, and daytime sampling. " 12/01/2011 - "Therefore, the purpose of this study was to answer the following questions: (1) Is serum cartilage oligomeric matrix protein (sCOMP) elevated in patients with radiographically diagnosed knee osteoarthritis (OA) compared to controls? " 11/01/2009 - "The aim of this study was to test the hypothesis that a change in serum cartilage oligomeric matrix protein (COMP) concentration is related to joint load during a 30-min walking exercise in patients with medial compartment knee osteoarthritis (OA) and in age-matched control subjects. " 05/01/2007 - "In this study we present data on serum cartilage oligomeric matrix protein (COMP) levels in a Brazilian population with isolated knee osteoarthritis (OA) compared to healthy controls. "
2.	Rheumatoid Arthritis 06/25/2022 - "The purpose of this study was to develop a fluorescence chromatography method for the detection of cartilage oligomeric matrix protein (COMP) in the auxiliary diagnosis of rheumatoid arthritis (RA). " 12/01/2017 - "The aim of the study is to investigate the correlation of serum cartilage oligomeric matrix protein (COMP) levels with articular cartilage damage based on sonographic knee cartilage thickness (KCT) and disease activity in rheumatoid arthritis (RA). " 06/01/2008 - "Value of serum cartilage oligomeric matrix protein as a prognostic marker of large-joint damage in rheumatoid arthritis--data from the RAPIT study." 01/01/2004 - "This study examined the serum and synovial fluid concentrations of cartilage oligomeric matrix protein (COMP) in relation to the evolution of joint cartilage damage and the requirement for surgery in 125 patients with rheumatoid arthritis (RA). " 12/01/2017 - "Relationship between cartilage oligomeric matrix protein (COMP) and rheumatoid arthritis severity."
3.	Juvenile Arthritis (Juvenile Idiopathic Arthritis) 05/01/2017 - "Circulating cartilage oligomeric matrix protein in juvenile idiopathic arthritis." 08/01/2009 - "Cartilage oligomeric matrix protein in patients with juvenile idiopathic arthritis: relation to growth and disease activity." 05/01/2006 - "Clinical significance of decreased serum concentration of cartilage oligomeric matrix protein in systemic juvenile idiopathic arthritis." 01/01/2009 - "In this study, we determined serum cartilage oligomeric matrix protein (COMP) levels in systemic juvenile idiopathic arthritis (sJIA) patients during both the active and the remission phases to investigate how the growth cartilage turnover changed under tocilizumab treatment. " 01/01/2009 - "Improvement of reduced serum cartilage oligomeric matrix protein levels in systemic juvenile idiopathic arthritis patients treated with the anti-interleukin-6 receptor monoclonal antibody tocilizumab."
4.	Hypoxia (Hypoxemia) 10/01/2017 - "However, the role of Cartilage oligomeric matrix protein (COMP) in the development of hypoxia-induced pH is largely unknown. " 10/01/2017 - "Hypoxia decrease expression of cartilage oligomeric matrix protein to promote phenotype switching of pulmonary arterial smooth muscle cells." 11/01/2019 - "Potential role of cartilage oligomeric matrix protein in the modulation of pulmonary arterial smooth muscle superoxide by hypoxia." 11/02/2023 - "we previously reported in studies on organoid-cultured bovine pulmonary arteries that pulmonary hypertension (PH) conditions of exposure to hypoxia or endothelin-1 caused a loss of a cartilage oligomeric matrix protein (COMP) stabilization of bone morphogenetic protein receptor-2 (BMPR2) function, a known key process contributing to pulmonary hypertension development. " 11/01/2019 - "Because we recently reported evidence for chronic hypoxia decreasing expression of cartilage oligomeric matrix protein (COMP) and evidence for this controlling loss of pulmonary arterial smooth muscle bone morphogenetic protein receptor-2 (BMPR2) and contractile phenotype proteins, we examined if changes in superoxide metabolism could be an important factor in a bovine pulmonary artery (BPA), organoid cultured under hypoxia for 48 h model. "
5.	Rheumatic Diseases (Rheumatism) 06/01/2007 - "Cartilage oligomeric matrix protein level in rheumatic diseases: potential use as a marker for measuring articular cartilage damage and/or the therapeutic efficacy of treatments." 01/01/2004 - "Serum levels of cartilage oligomeric matrix protein are elevated in rheumatoid arthritis, but not in inflammatory rheumatic diseases such as psoriatic arthritis, reactive arthritis, Raynaud's syndrome, scleroderma, systemic lupus erythematosus, vasculitis and Sjögren's syndrome." 04/01/2016 - "RA = rheumatoid arthritis, RF = rheumatoid factor, DAS 28 = disease activity score, SDAI = simple disease activity index, CDAI = clinical disease activity index, ACR = American College of Rheumatology, EULAR = European League against Rheumatism, anti-CCP = antibodies against cyclic citrullinated proteins, anti-MCV = mutated citrullinated vimentin antibodies, anti-CarP = antibodies against carbamylated proteins, MBDA = multi biomarker disease activity test, COMP = cartilage oligomeric matrix protein, ADAs = antidrug antibodies, CDA = clinical disease activity index, SDAI = simplified disease activity index, ESR = erythrocyte sedimentation rate, CRP = C reactive protein, SAA = serum amyloid A, VCAM-1 = vascular cell adhesion molecule-1, IL-6 = interleukin-6, TNF-R1 = tumor necrosis factor receptor 1, EGF = epidermal growth factor, VEGF-A = vascular endothelial growth factor A."

Related Drugs and Biologics

1.	Anti-Citrullinated Protein Antibodies
2.	Collagen Type I (Type I Collagen)
3.	Angiopoietin-1
4.	tocilizumab (atlizumab)
5.	Etanercept (Enbrel)
6.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
7.	Immunoglobulin M (IgM)
8.	Biomarkers (Surrogate Marker)
9.	Proteins (Proteins, Gene)
10.	C-Reactive Protein

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Hip Replacement Arthroplasty (Total Hip Replacement)
4.	Diskectomy (Discectomy)
5.	Renal Dialysis (Hemodialysis)