Change in serum COMP concentration due to ambulatory load is not related to knee OA status.

Abstract

The aim of this study was to test the hypothesis that a change in serum cartilage oligomeric matrix protein (COMP) concentration is related to joint load during a 30-min walking exercise in patients with medial compartment knee osteoarthritis (OA) and in age-matched control subjects. Blood samples were drawn from 42 patients with medial compartment knee OA and from 41 healthy age-matched control subjects immediately before, immediately after, and 0.5, 1.5, 3.5, and 5.5 h after a 30-min walking exercise on a level outdoor walking track at self-selected normal speed. Serum COMP concentrations were determined using a commercial ELISA. Basic time-distance gait variables were recorded using an activity monitor. Joint loads were measured using gait analysis. Serum COMP concentrations increased immediately after the walking exercise (+6.3% and +5.6%; p < 0.001) and decreased over 5.5 h after the exercise (-11.1% and -14.6%; p < 0.040 and p = 0.001) in patients and control subjects, respectively. The magnitude of increase in COMP concentration did not differ between groups (p = 0.902) and did not correlate with any variables describing ambulatory loads at the joints of the lower extremity. These results, taken together with a previous study of a younger healthy population, suggest the possibility that the influence of ambulatory loads on cartilage turnover is dependent on age.

• Authors: Annegret Mündermann, Karen B King, R Lane Smith, Thomas P Andriacchi
• Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society (J Orthop Res) Vol. 27 Issue 11 Pg. 1408-13 (Nov 2009) ISSN: 1554-527X [Electronic] United States
• PMID: 19422040 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
• Copyright: (c) 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

Chemical References

• Cartilage Oligomeric Matrix Protein
• Extracellular Matrix Proteins
• Glycoproteins
• Matrilin Proteins
• TSP5 protein, human

Topics

• Adult
• Aged
• Cartilage Oligomeric Matrix Protein
• Extracellular Matrix Proteins (blood)
• Female
• Gait
• Glycoproteins (blood)
• Humans
• Male
• Matrilin Proteins
• Middle Aged
• Osteoarthritis, Knee (blood)
• Walking
• Weight-Bearing